4QEW
Crystal structure of BRD2(BD2) mutant with ligand ET bound (METHYL (2R)- 2-[(4S)-6-(4-CHLOROPHENYL)-8-METHOXY-1-METHYL-4H-[1,2,4]TRIAZOLO[4,3-A][1, 4]BENZODIAZEPIN-4-YL]BUTANOATE)
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 501 |
| Chain | Residue |
| A | TYR368 |
| A | LYS402 |
| A | ASP407 |
| A | GLU413 |
| A | ALA437 |
| A | MET438 |
| A | LYS441 |
| A | HOH610 |
| A | HOH616 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE 2PE A 502 |
| Chain | Residue |
| A | SER347 |
| A | LEU350 |
| A | LYS351 |
| A | GLU404 |
| A | ARG406 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE 31P A 503 |
| Chain | Residue |
| A | TRP370 |
| A | PRO371 |
| A | PHE372 |
| A | VAL376 |
| A | TYR386 |
| A | TYR428 |
| A | ASN429 |
| A | VAL435 |
| A | HOH622 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NI A 504 |
| Chain | Residue |
| A | ARG419 |
| A | ARG419 |
| A | HOH603 |
| A | HOH603 |
Functional Information from PROSITE/UniProt
| site_id | PS00633 |
| Number of Residues | 60 |
| Details | BROMODOMAIN_1 Bromodomain signature. AwpFykpvDasalgahDYHdiIkhpMdlstVkrkmenrd..Yrdaqefaadvrl.MfsNCykY |
| Chain | Residue | Details |
| A | ALA369-TYR428 | |
