8E3E
| ZBTB7A Zinc Finger Domain Bound to DNA Duplex Containing CAST sequence (#10) | 分子名称: | DNA (5'-D(*CP*TP*TP*TP*GP*GP*GP*GP*AP*GP*GP*GP*GP*TP*CP*TP*TP*TP*TP*AP*C)-3'), DNA (5'-D(*GP*GP*TP*AP*AP*AP*AP*GP*AP*CP*CP*CP*CP*TP*CP*CP*CP*CP*AP*AP*A)-3'), ZINC ION, ... | 著者 | Horton, J.R, Ren, R, Cheng, X. | 登録日 | 2022-08-17 | 公開日 | 2023-02-08 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.99 Å) | 主引用文献 | Structural basis for transcription factor ZBTB7A recognition of DNA and effects of ZBTB7A somatic mutations that occur in human acute myeloid leukemia. J.Biol.Chem., 299, 2023
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8E3D
| ZBTB7A Zinc Finger Domain Bound to DNA Duplex Containing CAST sequence (#11) | 分子名称: | 1,2-ETHANEDIOL, DNA (5'-D(*AP*TP*TP*TP*GP*GP*GP*GP*AP*GP*GP*GP*GP*TP*CP*TP*TP*TP*AP*AP*CP*C)-3'), DNA (5'-D(P*GP*GP*TP*AP*AP*AP*AP*GP*AP*CP*CP*CP*CP*TP*CP*CP*CP*CP*AP*AP*AP*T)-3'), ... | 著者 | Horton, J.R, Ren, R, Cheng, X. | 登録日 | 2022-08-17 | 公開日 | 2023-02-08 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.62 Å) | 主引用文献 | Structural basis for transcription factor ZBTB7A recognition of DNA and effects of ZBTB7A somatic mutations that occur in human acute myeloid leukemia. J.Biol.Chem., 299, 2023
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8F8Y
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8F8Z
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3EU9
| The ankyrin repeat domain of Huntingtin interacting protein 14 | 分子名称: | GLYCEROL, HISTIDINE, Huntingtin-interacting protein 14, ... | 著者 | Gao, T, Collins, R.E, Horton, J.R, Zhang, R, Zhang, X, Cheng, X. | 登録日 | 2008-10-09 | 公開日 | 2009-06-23 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | The ankyrin repeat domain of Huntingtin interacting protein 14 contains a surface aromatic cage, a potential site for methyl-lysine binding. Proteins, 76, 2009
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3FPD
| G9a-like protein lysine methyltransferase inhibition by BIX-01294 | 分子名称: | Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine, ... | 著者 | Chang, Y, Zhang, X, Horton, J.R, Cheng, X. | 登録日 | 2009-01-05 | 公開日 | 2009-02-17 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294. Nat.Struct.Mol.Biol., 16, 2009
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8FS2
| CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Inhibitor 11b (YD907) | 分子名称: | 1,2-ETHANEDIOL, 5'-S-{3-[N'-(cyclohexylmethyl)carbamimidamido]propyl}-N-(3-phenylpropyl)-5'-thioadenosine, DNA (5'-D(*TP*TP*CP*AP*AP*AP*AP*AP*GP*TP*CP*CP*CP*A)-3'), ... | 著者 | Zhou, J, Horton, J.R, Cheng, X. | 登録日 | 2023-01-09 | 公開日 | 2023-05-10 | 最終更新日 | 2023-05-17 | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | 主引用文献 | Comparative Study of Adenosine Analogs as Inhibitors of Protein Arginine Methyltransferases and a Clostridioides difficile- Specific DNA Adenine Methyltransferase. Acs Chem.Biol., 18, 2023
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8FS1
| CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Inhibitor 11a (YD905) | 分子名称: | 1,2-ETHANEDIOL, 5'-S-{2-[N'-(cyclohexylmethyl)carbamimidamido]ethyl}-N-(3-phenylpropyl)-5'-thioadenosine, DNA (5'-D(*AP*TP*GP*GP*GP*AP*CP*TP*TP*TP*TP*TP*GP*A)-3'), ... | 著者 | Zhou, J, Horton, J.R, Cheng, X. | 登録日 | 2023-01-09 | 公開日 | 2023-05-10 | 最終更新日 | 2023-05-17 | 実験手法 | X-RAY DIFFRACTION (2.74 Å) | 主引用文献 | Comparative Study of Adenosine Analogs as Inhibitors of Protein Arginine Methyltransferases and a Clostridioides difficile- Specific DNA Adenine Methyltransferase. Acs Chem.Biol., 18, 2023
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10MH
| TERNARY STRUCTURE OF HHAI METHYLTRANSFERASE WITH ADOHCY AND HEMIMETHYLATED DNA CONTAINING 5,6-DIHYDRO-5-AZACYTOSINE AT THE TARGET | 分子名称: | DNA (5'-D(P*CP*CP*AP*TP*GP*(5CM)P*GP*CP*TP*GP*AP*C)-3'), DNA (5'-D(P*GP*TP*CP*AP*GP*5NCP*GP*CP*AP*TP*GP*G)-3'), PROTEIN (CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI), ... | 著者 | Sheikhnejad, G, Brank, A, Christman, J.K, Goddard, A, Alvarez, E, Ford Junior, H, Marquez, V.E, Marasco, C.J, Sufrin, J.R, O'Gara, M, Cheng, X. | 登録日 | 1998-08-10 | 公開日 | 1999-02-09 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Mechanism of inhibition of DNA (cytosine C5)-methyltransferases by oligodeoxyribonucleotides containing 5,6-dihydro-5-azacytosine. J.Mol.Biol., 285, 1999
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16VP
| CONSERVED CORE OF THE HERPES SIMPLEX VIRUS TRANSCRIPTIONAL REGULATORY PROTEIN VP16 | 分子名称: | PROTEIN (VP16, VMW65, ATIF), ... | 著者 | Liu, Y, Gong, W, Huang, C.C, Herr, W, Cheng, X. | 登録日 | 1999-02-11 | 公開日 | 1999-07-28 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal structure of the conserved core of the herpes simplex virus transcriptional regulatory protein VP16. Genes Dev., 13, 1999
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8S9M
| DNA cytosine-N4 methyltransferase (residues 79-324) from the Bdelloid rotifer Adineta vaga | 分子名称: | 1,2-ETHANEDIOL, DNA cytosine-N4 methyltransferase, SINEFUNGIN | 著者 | Zhou, J, Horton, J.R, Cheng, X. | 登録日 | 2023-03-29 | 公開日 | 2023-08-02 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | 主引用文献 | Biochemical and structural characterization of the first-discovered metazoan DNA cytosine-N4 methyltransferase from the bdelloid rotifer Adineta vaga. J.Biol.Chem., 299, 2023
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8S9N
| DNA cytosine-N4 methyltransferase (residues 61-324) from the Bdelloid rotifer Adineta vaga - C2 crystal form | 分子名称: | 1,2-ETHANEDIOL, DNA cytosine-N4 methyltransferase, SINEFUNGIN | 著者 | Zhou, J, Horton, J.R, Cheng, X. | 登録日 | 2023-03-29 | 公開日 | 2023-08-02 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Biochemical and structural characterization of the first-discovered metazoan DNA cytosine-N4 methyltransferase from the bdelloid rotifer Adineta vaga. J.Biol.Chem., 299, 2023
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8S9O
| DNA cytosine-N4 methyltransferase (residues 61-324) from the Bdelloid rotifer Adineta vaga - P1 crystal form | 分子名称: | 1,2-ETHANEDIOL, DNA cytosine-N4 methyltransferase, SINEFUNGIN | 著者 | Zhou, J, Horton, J.R, Cheng, X. | 登録日 | 2023-03-29 | 公開日 | 2023-08-02 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Biochemical and structural characterization of the first-discovered metazoan DNA cytosine-N4 methyltransferase from the bdelloid rotifer Adineta vaga. J.Biol.Chem., 299, 2023
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1BM8
| DNA-BINDING DOMAIN OF MBP1 | 分子名称: | TRANSCRIPTION FACTOR MBP1 | 著者 | Xu, R.-M, Koch, C, Liu, Y, Horton, J.R, Knapp, D, Nasmyth, K, Cheng, X. | 登録日 | 1998-07-29 | 公開日 | 1999-03-02 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | 主引用文献 | Crystal structure of the DNA-binding domain of Mbp1, a transcription factor important in cell-cycle control of DNA synthesis. Structure, 5, 1997
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1XSZ
| The structure of RalF | 分子名称: | guanine nucleotide exchange protein | 著者 | Amor, J.C, Swails, J, Roy, C.R, Nagai, H, Ingmundson, A, Cheng, X, Kahn, R.A. | 登録日 | 2004-10-20 | 公開日 | 2004-11-02 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.41 Å) | 主引用文献 | The structure of RalF, an ADP-ribosylation factor guanine nucleotide exchange factor from Legionella pneumophila, reveals the presence of a cap over the active site J.Biol.Chem., 280, 2005
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1XT0
| The Structure of N-terminal Sec7 domain of RalF | 分子名称: | guanine nucleotide exchange protein | 著者 | Amor, J.C, Swails, J, Roy, C.R, Nagai, H, Ingmundson, A, Cheng, X, Kahn, R.A. | 登録日 | 2004-10-20 | 公開日 | 2004-11-02 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.16 Å) | 主引用文献 | The structure of RalF, an ADP-ribosylation factor guanine nucleotide exchange factor from Legionella pneumophila, reveals the presence of a cap over the active site J.Biol.Chem., 280, 2005
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7N5U
| ZBTB7A Zinc Finger Domain Bound to DNA Duplex Containing GGACCC (Oligo 21) | 分子名称: | DNA Strain II, DNA Strand I, ZINC ION, ... | 著者 | Horton, J.R, Ren, R, Cheng, X. | 登録日 | 2021-06-06 | 公開日 | 2022-06-08 | 最終更新日 | 2023-02-15 | 実験手法 | X-RAY DIFFRACTION (2.86 Å) | 主引用文献 | Structural basis for transcription factor ZBTB7A recognition of DNA and effects of ZBTB7A somatic mutations that occur in human acute myeloid leukemia. J.Biol.Chem., 299, 2023
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7N5W
| ZBTB7A Zinc Finger Domain Bound to DNA Duplex Containing GGACCC (Oligo 23) | 分子名称: | 1,2-ETHANEDIOL, DNA Strand I, DNA Strand II, ... | 著者 | Horton, J.R, Ren, R, Cheng, X. | 登録日 | 2021-06-06 | 公開日 | 2022-06-08 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | 主引用文献 | Structural basis for transcription factor ZBTB7A recognition of DNA and effects of ZBTB7A somatic mutations that occur in human acute myeloid leukemia. J.Biol.Chem., 299, 2023
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7N5V
| ZBTB7A Zinc Finger Domain Bound to DNA Duplex Containing GGACCC (Oligo 20) | 分子名称: | DNA Strand I, DNA Strand II, ZINC ION, ... | 著者 | Horton, J.R, Ren, R, Cheng, X. | 登録日 | 2021-06-06 | 公開日 | 2022-06-08 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (3.08 Å) | 主引用文献 | Structural basis for transcription factor ZBTB7A recognition of DNA and effects of ZBTB7A somatic mutations that occur in human acute myeloid leukemia. J.Biol.Chem., 299, 2023
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2ORE
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1SKM
| HhaI methyltransferase in complex with DNA containing an abasic south carbocyclic sugar at its target site | 分子名称: | 5'-D(*T*GP*TP*CP*AP*GP*(HCX)P*GP*CP*AP*TP*GP*G)-3', 5'-D(*TP*CP*CP*AP*TP*GP*CP*GP*CP*TP*GP*AP*C)-3', Modification methylase HhaI, ... | 著者 | Horton, J.R, Ratner, G, Banavali, N, Huang, N, Marquez, V.E, MacKerell, A.D, Cheng, X. | 登録日 | 2004-03-05 | 公開日 | 2004-08-24 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Caught in the act: visualization of an intermediate in the DNA base-flipping pathway induced by HhaI methyltransferase Nucleic Acids Res., 32, 2004
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1T43
| Crystal Structure Analysis of E.coli Protein (N5)-Glutamine Methyltransferase (HemK) | 分子名称: | Protein methyltransferase hemK, S-ADENOSYL-L-HOMOCYSTEINE | 著者 | Yang, Z, Shipman, L, Zhang, M, Anton, B.P, Roberts, R.J, Cheng, X. | 登録日 | 2004-04-28 | 公開日 | 2004-06-29 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structural characterization and comparative phylogenetic analysis of Escherichia coli HemK, a protein (N5)-glutamine methyltransferase. J.Mol.Biol., 340, 2004
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5ISL
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5IVC
| Linked KDM5A Jmj Domain Bound to the Inhibitor N3 (4'-[(2-phenylethyl)carbamoyl][2,2'-bipyridine]-4-carboxylic acid) | 分子名称: | 1,2-ETHANEDIOL, 4'-[(2-phenylethyl)carbamoyl][2,2'-bipyridine]-4-carboxylic acid, GLYCEROL, ... | 著者 | Horton, J.R, Cheng, X. | 登録日 | 2016-03-20 | 公開日 | 2016-07-27 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.573 Å) | 主引用文献 | Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds. Cell Chem Biol, 23, 2016
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5IVB
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