8HW2
| Cryo-EM structure of beta-estradiol 17-(beta-D-glucuronide)-bound human ABC transporter ABCC3 in nanodiscs | Descriptor: | ATP-binding cassette sub-family C member 3, Estradiol-17beta-glucuronide | Authors: | Wang, J, Wang, F.F, Chen, Y.X, Zhou, C.Z. | Deposit date: | 2022-12-28 | Release date: | 2023-06-07 | Last modified: | 2023-10-11 | Method: | ELECTRON MICROSCOPY (3.65 Å) | Cite: | Placing steroid hormones within the human ABCC3 transporter reveals a compatible amphiphilic substrate-binding pocket. Embo J., 42, 2023
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8HW4
| Cryo-EM structure of dehydroepiandrosterone sulfate-bound human ABC transporter ABCC3 in nanodiscs | Descriptor: | 17-oxoandrost-5-en-3beta-yl hydrogen sulfate, ATP-binding cassette sub-family C member 3 | Authors: | Wang, J, Wang, F.F, Chen, Y.X, Zhou, C.Z. | Deposit date: | 2022-12-28 | Release date: | 2023-06-07 | Last modified: | 2023-10-11 | Method: | ELECTRON MICROSCOPY (3.52 Å) | Cite: | Placing steroid hormones within the human ABCC3 transporter reveals a compatible amphiphilic substrate-binding pocket. Embo J., 42, 2023
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8HVH
| Cryo-EM structure of ABC transporter ABCC3 | Descriptor: | ATP-binding cassette sub-family C member 3 | Authors: | Wang, J, Wang, F.F, Chen, Y.X, Zhou, C.Z. | Deposit date: | 2022-12-26 | Release date: | 2023-06-07 | Last modified: | 2023-10-11 | Method: | ELECTRON MICROSCOPY (3.07 Å) | Cite: | Placing steroid hormones within the human ABCC3 transporter reveals a compatible amphiphilic substrate-binding pocket. Embo J., 42, 2023
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4E0H
| Crystal structure of FAD binding domain of Erv1 from Saccharomyces cerevisiae | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Mitochondrial FAD-linked sulfhydryl oxidase ERV1 | Authors: | Guo, P.C, Ma, J.D, Jiang, Y.L, Wang, S.J, Hu, T.T, Chen, Y.X, Zhou, C.Z. | Deposit date: | 2012-03-04 | Release date: | 2012-08-29 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of yeast sulfhydryl oxidase erv1 reveals electron transfer of the disulfide relay system in the mitochondrial intermembrane space J.Biol.Chem., 287, 2012
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4E0I
| Crystal structure of the C30S/C133S mutant of Erv1 from Saccharomyces cerevisiae | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Mitochondrial FAD-linked sulfhydryl oxidase ERV1 | Authors: | Guo, P.C, Ma, J.D, Jiang, Y.L, Wang, S.J, Hu, T.T, Chen, Y.X, Zhou, C.Z. | Deposit date: | 2012-03-04 | Release date: | 2012-08-29 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structure of yeast sulfhydryl oxidase erv1 reveals electron transfer of the disulfide relay system in the mitochondrial intermembrane space J.Biol.Chem., 287, 2012
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3HKS
| Crystal structure of eukaryotic translation initiation factor eIF-5A2 from Arabidopsis thaliana | Descriptor: | 1,2-ETHANEDIOL, Eukaryotic translation initiation factor 5A-2 | Authors: | Teng, Y.B, He, Y.X, Jiang, Y.L, Chen, Y.X, Zhou, C.Z. | Deposit date: | 2009-05-25 | Release date: | 2009-09-29 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of Arabidopsis translation initiation factor eIF-5A2 Proteins, 77, 2009
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8JXU
| Cryo-EM structure of human ABC transporter ABCC2 under active turnover condition | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 2, ... | Authors: | Mao, Y.X, Chen, Z.P, Wang, L, Hou, W.T, Chen, Y.X, Zhou, C.Z. | Deposit date: | 2023-07-01 | Release date: | 2024-01-03 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (3.55 Å) | Cite: | Transport mechanism of human bilirubin transporter ABCC2 tuned by the inter-module regulatory domain. Nat Commun, 15, 2024
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8JX7
| Cryo-EM structure of human ABC transporter ABCC2 | Descriptor: | ATP-binding cassette sub-family C member 2 | Authors: | Mao, Y.X, Chen, Z.P, Wang, L, Hou, W.T, Chen, Y.X, Zhou, C.Z. | Deposit date: | 2023-06-30 | Release date: | 2024-01-03 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Transport mechanism of human bilirubin transporter ABCC2 tuned by the inter-module regulatory domain. Nat Commun, 15, 2024
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8JY5
| Cryo-EM structure of human ABC transporter ABCC2 in apo" state | Descriptor: | ATP-binding cassette sub-family C member 2 | Authors: | Mao, Y.X, Chen, Z.P, Wang, L, Hou, W.T, Chen, Y.X, Zhou, C.Z. | Deposit date: | 2023-07-03 | Release date: | 2024-01-03 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (4.17 Å) | Cite: | Transport mechanism of human bilirubin transporter ABCC2 tuned by the inter-module regulatory domain. Nat Commun, 15, 2024
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8JY4
| Cryo-EM structure of human ABC transporter ABCC2 in apo' state | Descriptor: | ATP-binding cassette sub-family C member 2 | Authors: | Mao, Y.X, Chen, Z.P, Wang, L, Hou, W.T, Chen, Y.X, Zhou, C.Z. | Deposit date: | 2023-07-02 | Release date: | 2024-01-03 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (3.58 Å) | Cite: | Transport mechanism of human bilirubin transporter ABCC2 tuned by the inter-module regulatory domain. Nat Commun, 15, 2024
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8JXQ
| Cryo-EM structure of bilirubin ditaurate (BDT) bound human ABC transporter ABCC2 | Descriptor: | 2-[3-[5-[(E)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-2-[[5-[(3-ethenyl-4-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-4-methyl-3-[3-oxidanylidene-3-(2-sulfoethylamino)propyl]-1H-pyrrol-2-yl]methyl]-4-methyl-1H-pyrrol-3-yl]propanoylamino]ethanesulfonic acid, ATP-binding cassette sub-family C member 2, CHOLESTEROL | Authors: | Mao, Y.X, Chen, Z.P, Wang, L, Hou, W.T, Chen, Y.X, Zhou, C.Z. | Deposit date: | 2023-07-01 | Release date: | 2024-01-03 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (3.32 Å) | Cite: | Transport mechanism of human bilirubin transporter ABCC2 tuned by the inter-module regulatory domain. Nat Commun, 15, 2024
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3T5I
| Structure of Fully modified farnesylated Rheb Peptide in complex with PDE6D | Descriptor: | C-terminal Farnesylated Rheb peptide CSQQGKSS(CMT), FARNESYL, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | Authors: | Ismail, S.A, Chen, Y.-X, Wittinghofer, A. | Deposit date: | 2011-07-27 | Release date: | 2011-11-02 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo. Nat.Chem.Biol., 7, 2011
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3T5G
| Structure of fully modified farnesylated Rheb in complex with PDE6D | Descriptor: | FARNESYL, GTP-binding protein Rheb, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Ismail, S.A, Chen, Y.-X, Wittinghofer, A. | Deposit date: | 2011-07-27 | Release date: | 2011-10-26 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo. Nat.Chem.Biol., 7, 2011
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7Q9Q
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7Q9S
| Crystal structure of PDE6D KRas peptide complex with Compound-1 | Descriptor: | 1,2-ETHANEDIOL, 2-methyl-3-(1~{H}-pyrazol-5-yl)imidazo[1,2-a]pyridine, DIMETHYL SULFOXIDE, ... | Authors: | Yelland, T, Ismail, S. | Deposit date: | 2021-11-14 | Release date: | 2022-01-19 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Stabilization of the RAS:PDE6D Complex Is a Novel Strategy to Inhibit RAS Signaling. J.Med.Chem., 65, 2022
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7Q9R
| Cocrystal structure of PDE6D bound to NRAS peptide | Descriptor: | 1,2-ETHANEDIOL, FARNESYL, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, ... | Authors: | Yelland, T, Ismail, S. | Deposit date: | 2021-11-14 | Release date: | 2022-01-19 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Stabilization of the RAS:PDE6D Complex Is a Novel Strategy to Inhibit RAS Signaling. J.Med.Chem., 65, 2022
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7QF9
| Crystal structure of PDE6D bound to HRas peptide | Descriptor: | 1,2-ETHANEDIOL, FARNESYL, HRas peptide, ... | Authors: | Yelland, T, Ismail, I. | Deposit date: | 2021-12-05 | Release date: | 2022-02-09 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Stabilization of the RAS:PDE6D Complex Is a Novel Strategy to Inhibit RAS Signaling. J.Med.Chem., 65, 2022
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7Q9U
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7QJK
| Crystal structure of PDE6D in complex with Compound-2 | Descriptor: | 1,2-ETHANEDIOL, N-(phenylmethyl)pyridin-2-amine, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, ... | Authors: | Yelland, T, Ismail, S. | Deposit date: | 2021-12-16 | Release date: | 2022-01-26 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Stabilization of the RAS:PDE6D Complex Is a Novel Strategy to Inhibit RAS Signaling. J.Med.Chem., 65, 2022
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4R0M
| Structure of McyG A-PCP complexed with phenylalanyl-adenylate | Descriptor: | ADENOSINE-5'-[PHENYLALANINYL-PHOSPHATE], McyG protein | Authors: | Tan, X.F, Dai, Y.N, Zhou, K, Jiang, Y.L, Ren, Y.M, Chen, Y.X, Zhou, C.Z. | Deposit date: | 2014-08-01 | Release date: | 2015-04-15 | Last modified: | 2019-12-18 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Structure of the adenylation-peptidyl carrier protein didomain of the Microcystis aeruginosa microcystin synthetase McyG. Acta Crystallogr.,Sect.D, 71, 2015
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8WM8
| Cryo-EM structure of cyanobacterial nitrate/nitrite transporter NrtBCD in complex with nitrate | Descriptor: | NITRATE ION, Nitrate transport ATP-binding protein, Nitrate transport permease protein | Authors: | Li, B, Zhou, C.Z, Chen, Y.X, Jiang, Y.L. | Deposit date: | 2023-10-03 | Release date: | 2024-02-28 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.54 Å) | Cite: | Allosteric regulation of nitrate transporter NRT via the signaling protein PII. Proc.Natl.Acad.Sci.USA, 121, 2024
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8W9M
| Cryo-EM structure of the cyanobacterial nitrate transporter NrtBCD in complex with ATP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Nitrate transport ATP-binding protein, ... | Authors: | Li, B, Zhou, C.Z, Chen, Y.X, Jiang, Y.L. | Deposit date: | 2023-09-05 | Release date: | 2024-02-28 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Allosteric regulation of nitrate transporter NRT via the signaling protein PII. Proc.Natl.Acad.Sci.USA, 121, 2024
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8WM7
| Cryo-EM structure of cyanobacterial nitrate/nitrite transporter NrtBCD in complex with signalling protein PII | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Nitrate transport ATP-binding protein, Nitrate transport permease protein, ... | Authors: | Li, B, Zhou, C.Z, Chen, Y.X, Jiang, Y.L. | Deposit date: | 2023-10-03 | Release date: | 2024-02-28 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.53 Å) | Cite: | Allosteric regulation of nitrate transporter NRT via the signaling protein PII. Proc.Natl.Acad.Sci.USA, 121, 2024
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4GOJ
| The Crystal Structure of full length Arl3GppNHp in complex with UNC119a | Descriptor: | ADP-ribosylation factor-like protein 3, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | Authors: | Ismail, S, Xiang-Chen, Y, Miertzschke, M, Vetter, I, Koerner, C, Wittinghofer, A. | Deposit date: | 2012-08-20 | Release date: | 2012-09-19 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural basis for Arl3-specific release of myristoylated ciliary cargo from UNC119. Embo J., 31, 2012
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4GOK
| The Crystal structure of Arl2GppNHp in complex with UNC119a | Descriptor: | ADP-ribosylation factor-like protein 2, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | Authors: | Ismail, S, Xiang-Chen, Y, Miertzschke, M, Vetter, I, Koerner, C, Wittinghofer, A. | Deposit date: | 2012-08-20 | Release date: | 2012-09-19 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural basis for Arl3-specific release of myristoylated ciliary cargo from UNC119. Embo J., 31, 2012
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