8WEJ
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6BV3
| Crystal structure of porcine aminopeptidase-N with Leucine | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Chen, L, Lin, Y.-L, Li, F. | 登録日 | 2017-12-12 | 公開日 | 2018-01-17 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The Rational Design of Therapeutic Peptides for Aminopeptidase N using a Substrate-Based Approach. Sci Rep, 7, 2017
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7L7S
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5F9W
| Crystal structure of broadly neutralizing VH1-46 germline-derived CD4-binding site-directed antibody CH235 in complex with HIV-1 clade A/E 93TH057 gp120 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of CH235-lineage antibody CH235, Light chain of CH235-lineage antibody CH235, ... | 著者 | Chen, L, Zhou, T, Kwong, P.D. | 登録日 | 2015-12-10 | 公開日 | 2016-03-09 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.8911 Å) | 主引用文献 | Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody. Cell, 165, 2016
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5TDG
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5TDL
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8GZ3
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6L48
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6L47
| Structure of the human sterol O-acyltransferase 1 in complex with CI-976 | 分子名称: | 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide, CHOLESTEROL, Sterol O-acyltransferase 1 | 著者 | Chen, L, Guan, C, Niu, Y. | 登録日 | 2019-10-16 | 公開日 | 2020-04-29 | 最終更新日 | 2020-10-07 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structural insights into the inhibition mechanism of human sterol O-acyltransferase 1 by a competitive inhibitor. Nat Commun, 11, 2020
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7CU3
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3DAE
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6JB1
| Structure of pancreatic ATP-sensitive potassium channel bound with repaglinide and ATPgammaS at 3.3A resolution | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, ... | 著者 | Chen, L, Ding, D, Wang, M, Wu, J.-X, Kang, Y. | 登録日 | 2019-01-25 | 公開日 | 2019-05-22 | 最終更新日 | 2021-09-29 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | The Structural Basis for the Binding of Repaglinide to the Pancreatic KATPChannel. Cell Rep, 27, 2019
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6JPF
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6JB3
| Structure of SUR1 subunit bound with repaglinide | 分子名称: | ATP-binding cassette sub-family C member 8 isoform X2, Digitonin, Repaglinide | 著者 | Chen, L, Ding, D, Wang, M, Wu, J.-X, Kang, Y. | 登録日 | 2019-01-25 | 公開日 | 2019-05-22 | 最終更新日 | 2021-09-29 | 実験手法 | ELECTRON MICROSCOPY (3.001 Å) | 主引用文献 | The Structural Basis for the Binding of Repaglinide to the Pancreatic KATPChannel. Cell Rep, 27, 2019
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6JT2
| Structure of human soluble guanylate cyclase in the NO activated state | 分子名称: | Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, MAGNESIUM ION, ... | 著者 | Chen, L, Kang, Y, Liu, R, Wu, J.-X. | 登録日 | 2019-04-08 | 公開日 | 2019-09-04 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structural insights into the mechanism of human soluble guanylate cyclase. Nature, 574, 2019
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2LOZ
| The novel binding mode of DLC1 and Tensin2 PTB domain | 分子名称: | Rho GTPase-activating protein 7, Tensin-like C1 domain-containing phosphatase | 著者 | Liu, C, Chen, L, Zhu, G. | 登録日 | 2012-01-29 | 公開日 | 2012-06-06 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of the phosphotyrosine binding (PTB) domain of human tensin2 protein in complex with deleted in liver cancer 1 (DLC1) peptide reveals a novel peptide binding mode. J.Biol.Chem., 287, 2012
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3RJ2
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3RPT
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3MQ0
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5ZBG
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5YX9
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7E3X
| Crystal structure of SDR family NAD(P)-dependent oxidoreductase from exiguobacterium | 分子名称: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Oxidoreductase | 著者 | Chen, L, Tang, J, Yuan, S, Zhang, F, Chen, S. | 登録日 | 2021-02-09 | 公開日 | 2021-09-29 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.58 Å) | 主引用文献 | Structure-guided evolution of a ketoreductase forefficient and stereoselective bioreduction of bulkyalpha-aminobeta-keto esters Catalysis Science And Technology, 2021
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4U1W
| Full length GluA2-kainate-(R,R)-2b complex crystal form A | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, Glutamate receptor 2, ... | 著者 | Chen, L, Gouaux, E. | 登録日 | 2014-07-16 | 公開日 | 2014-08-20 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | 主引用文献 | Structure and Dynamics of AMPA Receptor GluA2 in Resting, Pre-Open, and Desensitized States. Cell, 158, 2014
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7YSH
| Cryo-EM Structure of FGF23-FGFR1c-aKlotho-HS Quaternary Complex | 分子名称: | 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, COPPER (II) ION, Fibroblast growth factor 23, ... | 著者 | Mohammadi, M, Chen, L. | 登録日 | 2022-08-12 | 公開日 | 2023-04-19 | 最終更新日 | 2023-07-05 | 実験手法 | ELECTRON MICROSCOPY (2.74 Å) | 主引用文献 | Structural basis for FGF hormone signalling. Nature, 618, 2023
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7YSU
| Cryo-EM Structure of FGF23-FGFR3c-aKlotho-HS Quaternary Complex | 分子名称: | 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, COPPER (II) ION, Fibroblast growth factor 23, ... | 著者 | Mohammadi, M, Chen, L. | 登録日 | 2022-08-13 | 公開日 | 2023-04-19 | 最終更新日 | 2023-07-05 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural basis for FGF hormone signalling. Nature, 618, 2023
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