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8B4Q
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Ternary structure of 14-3-3s, ERRg phosphopeptide and dual-reactive compound 5
分子名称: 14-3-3 protein sigma, 3-fluoranyl-4-methanoyl-~{N}-methyl-~{N}-(2-sulfanylethyl)benzamide, CHLORIDE ION, ...
著者Somsen, B.A, Ottmann, C.
登録日2022-09-20
公開日2023-03-29
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERR gamma Protein-Protein Interaction as a Molecular Glue Drug Discovery Approach.
J.Am.Chem.Soc., 145, 2023
8B5P
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Ternary structure of 14-3-3s, ERRg phosphopeptide and dual-reactive compound 10
分子名称: 14-3-3 protein sigma, 3-bromanyl-5-methanoyl-~{N}-methyl-~{N}-(2-sulfanylethyl)benzamide, CHLORIDE ION, ...
著者Somsen, B.A, Ottmann, C.
登録日2022-09-23
公開日2023-03-29
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERR gamma Protein-Protein Interaction as a Molecular Glue Drug Discovery Approach.
J.Am.Chem.Soc., 145, 2023
8BM5
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Ternary structure of 14-3-3s, ERRg phosphopeptide and dual-reactive compound 7
分子名称: 14-3-3 protein sigma, 4-methanoyl-~{N}-methyl-~{N}-(2-sulfanylethyl)benzenesulfonamide, CHLORIDE ION, ...
著者Somsen, B.A, Ottmann, C.
登録日2022-11-10
公開日2023-03-29
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERR gamma Protein-Protein Interaction as a Molecular Glue Drug Discovery Approach.
J.Am.Chem.Soc., 145, 2023
8BJN
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BU of 8bjn by Molmil
Ternary structure of 14-3-3s, ERRg phosphopeptide and dual-reactive compound 6
分子名称: 14-3-3 protein sigma, 3-bromanyl-4-methanoyl-~{N}-methyl-~{N}-(2-sulfanylethyl)benzamide, CHLORIDE ION, ...
著者Somsen, B.A, Ottmann, C.
登録日2022-11-04
公開日2023-03-29
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERR gamma Protein-Protein Interaction as a Molecular Glue Drug Discovery Approach.
J.Am.Chem.Soc., 145, 2023
8BFC
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BU of 8bfc by Molmil
Binary structure of 14-3-3s and RND3 phosphopeptide
分子名称: 14-3-3 protein sigma, CHLORIDE ION, MAGNESIUM ION, ...
著者Somsen, B.A, Ottmann, C.
登録日2022-10-24
公開日2023-03-29
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERR gamma Protein-Protein Interaction as a Molecular Glue Drug Discovery Approach.
J.Am.Chem.Soc., 145, 2023
8BJG
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BU of 8bjg by Molmil
Ternary structure of 14-3-3s, ERRg phosphopeptide and dual-reactive compound 8
分子名称: 14-3-3 protein sigma, 3-methanoyl-~{N}-methyl-~{N}-(2-sulfanylethyl)benzamide, CHLORIDE ION, ...
著者Somsen, B.A, Ottmann, C.
登録日2022-11-04
公開日2023-03-29
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERR gamma Protein-Protein Interaction as a Molecular Glue Drug Discovery Approach.
J.Am.Chem.Soc., 145, 2023
8BI7
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BU of 8bi7 by Molmil
Binary structure of 14-3-3s and PKR phosphopeptide
分子名称: 14-3-3 protein sigma, MAGNESIUM ION, PKR phosphopeptide
著者Somsen, B.A, Ottmann, C.
登録日2022-11-01
公開日2023-03-29
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERR gamma Protein-Protein Interaction as a Molecular Glue Drug Discovery Approach.
J.Am.Chem.Soc., 145, 2023
8C07
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BU of 8c07 by Molmil
Structure of HECT E3 UBR5 forming K48 linked Ubiquitin chains
分子名称: 5-azanylpentan-2-one, E3 ubiquitin-protein ligase UBR5, Polyubiquitin-B
著者Hehl, L.A, Prabu, J.R, Schulman, B.A.
登録日2022-12-16
公開日2023-08-23
最終更新日2024-02-14
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Structural snapshots along K48-linked ubiquitin chain formation by the HECT E3 UBR5.
Nat.Chem.Biol., 20, 2024
8C06
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Structure of Dimeric HECT E3 Ubiquitin Ligase UBR5
分子名称: E3 ubiquitin-protein ligase UBR5, ZINC ION
著者Hehl, L.A, Prabu, J.R, Schulman, B.A.
登録日2022-12-16
公開日2023-08-23
最終更新日2024-02-14
実験手法ELECTRON MICROSCOPY (2.7 Å)
主引用文献Structural snapshots along K48-linked ubiquitin chain formation by the HECT E3 UBR5.
Nat.Chem.Biol., 20, 2024
8BD0
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BU of 8bd0 by Molmil
Human Gamma-D crystallin R36S mutant with DTT-Cystein Protein modification
分子名称: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Human Gamma-D Crystallin R36S
著者Yorke, B.A, Hill, J.A.
登録日2022-10-17
公開日2023-11-01
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献An ultraviolet-driven rescue pathway for oxidative stress to eye lens protein human gamma-D crystallin.
Commun Chem, 7, 2024
8C3Z
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BU of 8c3z by Molmil
14-3-3sigma bound to strep-tagged PKA-responsive ERa phosphopeptide
分子名称: 14-3-3 protein sigma, Estrogen receptor, MAGNESIUM ION
著者Somsen, B.A, Ottmann, C.
登録日2022-12-30
公開日2023-12-27
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Molecular basis and dual ligand regulation of tetrameric estrogen receptor alpha /14-3-3 zeta protein complex.
J.Biol.Chem., 299, 2023
8C42
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BU of 8c42 by Molmil
Ternary structure of 14-3-3sigma, PKA-responsive ERa phosphopeptide and Fusicoccin-A
分子名称: 14-3-3 protein sigma, De-acetylated Fusicoccin, Estrogen receptor, ...
著者Somsen, B.A, Ottmann, C.
登録日2022-12-30
公開日2023-12-27
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Molecular basis and dual ligand regulation of tetrameric estrogen receptor alpha /14-3-3 zeta protein complex.
J.Biol.Chem., 299, 2023
8C40
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BU of 8c40 by Molmil
14-3-3sigma bound to PKA-responsive ERa phosphopeptide
分子名称: 14-3-3 protein sigma, Estrogen Receptor alpha phosphopeptide, MAGNESIUM ION
著者Somsen, B.A, Ottmann, C.
登録日2022-12-30
公開日2023-12-27
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Molecular basis and dual ligand regulation of tetrameric estrogen receptor alpha /14-3-3 zeta protein complex.
J.Biol.Chem., 299, 2023
8C43
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BU of 8c43 by Molmil
Ternary structure of 14-3-3sigma, strep-tagged PKA-responsive ERa phosphopeptide, and Fusicoccin-A.
分子名称: 14-3-3 protein sigma, De-acetylated Fusicoccin, Estrogen Receptor alpha phosphopeptide, ...
著者Somsen, B.A, Ottmann, C.
登録日2022-12-30
公開日2023-12-27
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Molecular basis and dual ligand regulation of tetrameric estrogen receptor alpha /14-3-3 zeta protein complex.
J.Biol.Chem., 299, 2023
8CQF
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BU of 8cqf by Molmil
Crystal Structure of a Chimeric Alpha-Amylase from Pseudoalteromonas Haloplanktis Complexed with Rearranged Acarbose
分子名称: 1,2-ETHANEDIOL, 4,6-dideoxy-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranose-(1-4)-1,5-anhydro-D-glucitol, 4,6-dideoxy-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, ...
著者Skagseth, S, Griese, J.J, Lund, B.A, van der Ent, F, Aqvist, J.
登録日2023-03-06
公開日2023-06-21
最終更新日2023-07-12
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Computational design of the temperature optimum of an enzyme reaction.
Sci Adv, 9, 2023
8CQG
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BU of 8cqg by Molmil
Crystal Structure of a Chimeric Alpha-Amylase from Pseudoalteromonas Haloplanktis
分子名称: 1,2-ETHANEDIOL, Alpha-amylase, CALCIUM ION, ...
著者Skagseth, S, Lund, B.A, Griese, J.J, van der Ent, F, Aqvist, J.
登録日2023-03-06
公開日2023-06-21
最終更新日2023-07-12
実験手法X-RAY DIFFRACTION (1.74 Å)
主引用文献Computational design of the temperature optimum of an enzyme reaction.
Sci Adv, 9, 2023
8CDK
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BU of 8cdk by Molmil
CAND1 b-hairpin++-SCF-SKP2 CAND1 partly engaged SCF partly rocked
分子名称: Cullin-1, Cullin-associated NEDD8-dissociated protein 1, E3 ubiquitin-protein ligase RBX1, ...
著者Baek, K, Schulman, B.A.
登録日2023-01-31
公開日2023-04-19
最終更新日2023-05-10
実験手法ELECTRON MICROSCOPY (3.32 Å)
主引用文献Systemwide disassembly and assembly of SCF ubiquitin ligase complexes.
Cell, 186, 2023
8CDJ
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BU of 8cdj by Molmil
CAND1 b-hairpin++-SCF-SKP2 CAND1 rolling SCF engaged
分子名称: Cullin-1, Cullin-associated NEDD8-dissociated protein 1, E3 ubiquitin-protein ligase RBX1, ...
著者Baek, K, Schulman, B.A.
登録日2023-01-31
公開日2023-04-19
最終更新日2023-05-10
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Systemwide disassembly and assembly of SCF ubiquitin ligase complexes.
Cell, 186, 2023
8CAF
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BU of 8caf by Molmil
N8C_Fab3b in complex with NEDD8-CUL1(WHB)
分子名称: Cullin-1, Fab Heavy Chain, Fab Light Chain, ...
著者Duda, D.M, Yanishevski, D, Henneberg, L.T, Schulman, B.A.
登録日2023-01-24
公開日2023-09-13
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (2.66 Å)
主引用文献Activity-based profiling of cullin-RING E3 networks by conformation-specific probes.
Nat.Chem.Biol., 19, 2023
2L4K
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BU of 2l4k by Molmil
Water refined solution structure of the human Grb7-SH2 domain in complex with the 10 amino acid peptide pY1139
分子名称: Growth factor receptor-bound protein 7, Receptor tyrosine-protein kinase erbB-2
著者Pias, S.C, Ivancic, M, Brescia, P.J, Johnson, D.L, Smith, D.E, Daly, R.J, Lyons, B.A.
登録日2010-10-07
公開日2010-11-17
最終更新日2012-10-03
実験手法SOLUTION NMR
主引用文献Water-Refined Solution Structure of the Human Grb7-SH2 Domain in Complex with the erbB2 Receptor Peptide pY1139.
Protein Pept.Lett., 19, 2012
4BYZ
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BU of 4byz by Molmil
Structural characterization using Sulfur-SAD of the cytoplasmic domain of Burkholderia pseudomallei PilO2Bp, an actin-like protein component of a Type IVb R64-derivative pilus machinery.
分子名称: PHOSPHATE ION, POTASSIUM ION, TYPE IV PILUS BIOSYNTHESIS PROTEIN
著者Lassaux, P, Manjasetty, B.A, Conchillo-Sole, O, Yero, D, Gourlay, L, Perletti, L, Daura, X, Belrhali, H, Bolognesi, M.
登録日2013-07-22
公開日2014-04-23
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Redefining the Pf06864 Pfam Family Based on Burkholderia Pseudomallei Pilo2BP S-Sad Crystal Structure.
Plos One, 9, 2014
1ADX
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BU of 1adx by Molmil
FIFTH EGF-LIKE DOMAIN OF THROMBOMODULIN (TMEGF5), NMR, 14 STRUCTURES
分子名称: THROMBOMODULIN
著者Sampoli-Benitez, B.A, Hunter, M.J, Meininger, D.P, Komives, E.A.
登録日1997-02-18
公開日1997-12-24
最終更新日2022-02-16
実験手法SOLUTION NMR
主引用文献Structure of the fifth EGF-like domain of thrombomodulin: An EGF-like domain with a novel disulfide-bonding pattern.
J.Mol.Biol., 273, 1997
4BZ0
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BU of 4bz0 by Molmil
Structural characterization using Sulfur-SAD of the cytoplasmic domain of Burkholderia pseudomallei PilO2Bp, an actin-like protein component of a Type IVb R64-derivative pilus machinery.
分子名称: POTASSIUM ION, PUTATIVE TYPE IV PILUS BIOSYNTHESIS PROTEIN
著者Lassaux, P, Manjasetty, B.A, Conchillo-Sole, O, Yero, D, Gourlay, L, Perletti, L, Daura, X, Belrhali, H, Bolognesi, M.
登録日2013-07-22
公開日2014-04-23
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献Redefining the Pf06864 Pfam Family Based on Burkholderia Pseudomallei Pilo2BP S-Sad Crystal Structure.
Plos One, 9, 2014
4CQ6
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The crystal structure of the allene oxide cyclase 2 from Arabidopsis thaliana with bound inhibitor - vernolic acid
分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, (9Z)-11-[(2R,3S)-3-pentyloxiran-2-yl]undec-9-enoic acid, ALLENE OXIDE CYCLASE 2, ...
著者Terlecka, B.A, Pollmann, S, Hofmann, E.
登録日2014-02-11
公開日2015-03-04
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献The Ligand-Bound Structures of the Aoc2 from A. Thaliana and the Implications for the Catalytic Mechanism
To be Published
4CQ7
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The crystal structure of the allene oxide cyclase 2 from Arabidopsis thaliana with bound product - OPDA
分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, 9S,13R-12-OXOPHYTODIENOIC ACID, ALLENE OXIDE CYCLASE 2, ...
著者Terlecka, B.A, Pollmann, S, Hofmann, E.
登録日2014-02-11
公開日2015-03-04
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献The Ligand-Bound Structures of the Aoc2 from A. Thaliana and the Implications for the Catalytic Mechanism
To be Published

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件を2024-05-15に公開中

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