8CQF

Crystal Structure of a Chimeric Alpha-Amylase from Pseudoalteromonas Haloplanktis Complexed with Rearranged Acarbose

Summary for 8CQF

Entry DOI	10.2210/pdb8cqf/pdb
Descriptor	Alpha-amylase, 4,6-dideoxy-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, 4,6-dideoxy-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranose-(1-4)-1,5-anhydro-D-glucitol, ... (8 entities in total)
Functional Keywords	inhibitor, alpha-amylase, hydrolase, chimeric
Biological source	Pseudoalteromonas haloplanktis More
Total number of polymer chains	1
Total formula weight	51964.47
Authors	Skagseth, S.,Griese, J.J.,Lund, B.A.,van der Ent, F.,Aqvist, J. (deposition date: 2023-03-06, release date: 2023-06-21, Last modification date: 2023-07-12)
Primary citation	van der Ent, F.,Skagseth, S.,Lund, B.A.,Socan, J.,Griese, J.J.,Brandsdal, B.O.,Aqvist, J. Computational design of the temperature optimum of an enzyme reaction. Sci Adv, 9:eadi0963-eadi0963, 2023 Cited by PubMed: 37379391 DOI: 10.1126/sciadv.adi0963 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation