7UMO
 
 | | Structure of Unc119-inhibitor complex. | | 分子名称: | (3s,5s,7s)-N-(4,5-dichloropyridin-2-yl)adamantane-1-carboxamide, GLYCEROL, Protein unc-119 homolog A | | 著者 | Srivastava, D, Sebag, J.A, Artemyev, N.O. | | 登録日 | 2022-04-07 | | 公開日 | 2023-07-26 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Insulin sensitization by small molecules enhancing GLUT4 translocation.
Cell Chem Biol, 30, 2023
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8EOB
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8EOA
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6N85
 | | Resistance to inhibitors of cholinesterase 8A (Ric8A) protein in complex with MBP-tagged transducin-alpha residues 327-350 | | 分子名称: | Maltose/maltodextrin-binding periplasmic protein,Guanine nucleotide-binding protein G(t) subunit alpha-2, Synembryn-A, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | | 著者 | Srivastava, D, Gakhar, L, Artemyev, N.O. | | 登録日 | 2018-11-28 | | 公開日 | 2019-07-10 | | 最終更新日 | 2021-11-24 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structural underpinnings of Ric8A function as a G-protein alpha-subunit chaperone and guanine-nucleotide exchange factor.
Nat Commun, 10, 2019
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6N84
 | | MBP-fusion protein of transducin-alpha residues 327-350 | | 分子名称: | Maltose/maltodextrin-binding periplasmic protein,Guanine nucleotide-binding protein G(t) subunit alpha-2, SULFATE ION, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | | 著者 | Srivastava, D, Gakhar, L, Artemyev, N.O. | | 登録日 | 2018-11-28 | | 公開日 | 2019-07-10 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Structural underpinnings of Ric8A function as a G-protein alpha-subunit chaperone and guanine-nucleotide exchange factor.
Nat Commun, 10, 2019
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6N86
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6PX0
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3JWQ
 | | Crystal structure of chimeric PDE5/PDE6 catalytic domain complexed with sildenafil | | 分子名称: | 5-{2-ETHOXY-5-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-1-METHYL-3-PROPYL-1H,6H,7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE, MAGNESIUM ION, ZINC ION, ... | | 著者 | Barren, B, Gakhar, L, Muradov, H, Boyd, K.K, Ramaswamy, S, Artemyev, N.O. | | 登録日 | 2009-09-18 | | 公開日 | 2009-10-13 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.87 Å) | | 主引用文献 | Structural basis of phosphodiesterase 6 inhibition by the C-terminal region of the gamma-subunit
Embo J., 28, 2009
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3JWR
 | | Crystal structure of chimeric PDE5/PDE6 catalytic domain complexed with 3-isobutyl-1-methylxanthine (IBMX) and PDE6 gamma-subunit inhibitory peptide 70-87. | | 分子名称: | 3-ISOBUTYL-1-METHYLXANTHINE, MAGNESIUM ION, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma, ... | | 著者 | Barren, B, Gakhar, L, Muradov, H, Boyd, K.K, Ramaswamy, S, Artemyev, N.O. | | 登録日 | 2009-09-18 | | 公開日 | 2009-10-13 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.994 Å) | | 主引用文献 | Structural basis of phosphodiesterase 6 inhibition by the C-terminal region of the gamma-subunit
Embo J., 28, 2009
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5U9K
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5U9A
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5U9J
 | | Crystal structure of the FKBP domain of human aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1) complexed with geranyl geranyl pyrophoshate | | 分子名称: | Aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1), GERAN-8-YL GERAN, ISOPROPYL ALCOHOL, ... | | 著者 | Yadav, R.P, Gakhar, L, Liping, Y, Artemyev, N.O. | | 登録日 | 2016-12-16 | | 公開日 | 2017-07-26 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Unique structural features of the AIPL1-FKBP domain that support prenyl lipid binding and underlie protein malfunction in blindness.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5U9I
 | | Crystal structure of the FKBP domain of human aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1) complexed with S-farnesyl-L-cysteine methyl ester | | 分子名称: | Aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1), FARNESYL | | 著者 | Yadav, R.P, Gakhar, L, Liping, Y, Artemyev, N.O. | | 登録日 | 2016-12-16 | | 公開日 | 2017-07-26 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Unique structural features of the AIPL1-FKBP domain that support prenyl lipid binding and underlie protein malfunction in blindness.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5V35
 | | Crystal structure of V71F mutant of the FKBP domain of human aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1) complexed with S-farnesyl-L-cysteine methyl ester | | 分子名称: | Aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1), FARNESYL | | 著者 | Yadav, R.P, Gakhar, L, Liping, Y, Artemyev, N.O. | | 登録日 | 2017-03-06 | | 公開日 | 2017-07-26 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Unique structural features of the AIPL1-FKBP domain that support prenyl lipid binding and underlie protein malfunction in blindness.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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2JU4
 | | NMR structure of the gamma subunit of cGMP phosphodiesterase | | 分子名称: | (3'R)-1'-oxyl-2',2',5',5'-tetramethyl-1,3'-bipyrrolidine-2,5-dione, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma | | 著者 | Song, J, Guo, L.W, Ruoho, A.E, Markley, J.L, Center for Eukaryotic Structural Genomics (CESG) | | 登録日 | 2007-08-14 | | 公開日 | 2007-10-16 | | 最終更新日 | 2020-02-19 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Intrinsically disordered gamma-subunit of cGMP phosphodiesterase encodes functionally relevant transient secondary and tertiary structure.
Proc.Natl.Acad.Sci.USA, 105, 2008
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