3JWR
Crystal structure of chimeric PDE5/PDE6 catalytic domain complexed with 3-isobutyl-1-methylxanthine (IBMX) and PDE6 gamma-subunit inhibitory peptide 70-87.
Summary for 3JWR
Entry DOI | 10.2210/pdb3jwr/pdb |
Related | 3JWQ |
Descriptor | cGMP-specific 3',5'-cyclic phosphodiesterase catalytic domain, Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha chimera, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma, ZINC ION, ... (6 entities in total) |
Functional Keywords | mostly alpha, cgmp, hydrolase, polymorphism, sensory transduction, vision |
Biological source | Homo sapiens More |
Total number of polymer chains | 4 |
Total formula weight | 82225.69 |
Authors | Barren, B.,Gakhar, L.,Muradov, H.,Boyd, K.K.,Ramaswamy, S.,Artemyev, N.O. (deposition date: 2009-09-18, release date: 2009-10-13, Last modification date: 2023-09-06) |
Primary citation | Barren, B.,Gakhar, L.,Muradov, H.,Boyd, K.K.,Ramaswamy, S.,Artemyev, N.O. Structural basis of phosphodiesterase 6 inhibition by the C-terminal region of the gamma-subunit Embo J., 28:3613-3622, 2009 Cited by PubMed: 19798052DOI: 10.1038/emboj.2009.284 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.994 Å) |
Structure validation
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