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3JWR

Crystal structure of chimeric PDE5/PDE6 catalytic domain complexed with 3-isobutyl-1-methylxanthine (IBMX) and PDE6 gamma-subunit inhibitory peptide 70-87.

Functional Information from GO Data
ChainGOidnamespacecontents
A0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
A0007165biological_processsignal transduction
A0008081molecular_functionphosphoric diester hydrolase activity
B0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
B0007165biological_processsignal transduction
B0008081molecular_functionphosphoric diester hydrolase activity
C0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
C0007601biological_processvisual perception
C0030553molecular_functioncGMP binding
D0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
D0007601biological_processvisual perception
D0030553molecular_functioncGMP binding
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 899
ChainResidue
AHIS617
AHIS653
AASP654
AASP764

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE ZN B 899
ChainResidue
BASP764
BHOH12
BHOH18
BHIS617
BHIS653
BASP654

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MG A 900
ChainResidue
AHOH5
AASP654
AGLU682
ATHR723

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE IBM A 901
ChainResidue
AHIS613
ALEU765
AGLN817
APHE820

site_idAC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE IBM A 902
ChainResidue
ALEU693
AGLN699
ALEU701
ASER702
ALEU704
ATYR709

site_idAC6
Number of Residues6
DetailsBINDING SITE FOR RESIDUE IBM A 903
ChainResidue
AASP687
ALEU690
BALA545
BALA546
BVAL547
BHIS592

site_idAC7
Number of Residues7
DetailsBINDING SITE FOR RESIDUE MG B 900
ChainResidue
BHOH11
BHOH12
BHOH15
BHOH16
BASP654
BGLU682
BTHR723

site_idAC8
Number of Residues5
DetailsBINDING SITE FOR RESIDUE IBM B 901
ChainResidue
BLEU765
BVAL782
BPHE786
BGLN817
BPHE820

site_idAC9
Number of Residues6
DetailsBINDING SITE FOR RESIDUE IBM B 902
ChainResidue
BGLN699
BLEU701
BSER702
BLEU704
BILE706
BTYR709

Functional Information from PROSITE/UniProt
site_idPS00126
Number of Residues12
DetailsPDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHrGvnNsY
ChainResidueDetails
AHIS653-TYR664

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton donor => ECO:0000250|UniProtKB:O76083
ChainResidueDetails
AHIS613
BHIS613

site_idSWS_FT_FI2
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:12955149, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1T9R, ECO:0007744|PDB:1T9S, ECO:0007744|PDB:1TBF
ChainResidueDetails
AHIS617
AHIS653
AASP654
AASP764
BHIS617
BHIS653
BASP654
BASP764

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PDB entries from 2024-07-24

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