3JWR

Crystal structure of chimeric PDE5/PDE6 catalytic domain complexed with 3-isobutyl-1-methylxanthine (IBMX) and PDE6 gamma-subunit inhibitory peptide 70-87.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	cGMP-specific 3',5'-cyclic phosphodiesterase catalytic domain, Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha chimera	polymer	330	38282.1	2	UniProt (O76074) UniProt (P51160) Pfam (PF00233)	Homo sapiens	cGMP-binding cGMP-specific phosphodiesterase, CGB-PDE, cGMP phosphodiesterase 6C
2	C, D (C, D)	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	polymer	18	2185.4	2	UniProt (P18545)	Homo sapiens	GMP-PDE gamma
3	E, J (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
4	F, K (A, B)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
5	G, H, I, L, M (A, B)	3-ISOBUTYL-1-METHYLXANTHINE	non-polymer		222.2	5	Chemie (IBM)
6	N, O, P (A, B, D)	water	water		18.0	17	Chemie (HOH)

Sequence modifications

A, B: 535 - 786 (UniProt: O76074)

PDB	External Database	Details
Gly 531	-	expression tag
Ser 532	-	expression tag
His 533	-	expression tag
Met 534	-	expression tag

A, B: 787 - 826 (UniProt: P51160)
A, B: 827 - 860 (UniProt: O76074)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	80935.0
Non-Polymers*	Number of molecules	9
	Total formula weight	1290.6
All*	Total formula weight	82225.7

*Water molecules are not included.