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3JWR

Crystal structure of chimeric PDE5/PDE6 catalytic domain complexed with 3-isobutyl-1-methylxanthine (IBMX) and PDE6 gamma-subunit inhibitory peptide 70-87.

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BcGMP-specific 3',5'-cyclic phosphodiesterase catalytic domain, Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha chimerapolymer33038282.12UniProt (O76074)
UniProt (P51160)
Pfam (PF00233)
In PDB
Homo sapienscGMP-binding cGMP-specific phosphodiesterase, CGB-PDE, cGMP phosphodiesterase 6C
2C, DRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammapolymer182185.42UniProt (P18545)
In PDB
Homo sapiensGMP-PDE gamma
3A, BZINC IONnon-polymer65.42Chemie (ZN)
4A, BMAGNESIUM IONnon-polymer24.32Chemie (MG)
5A, B3-ISOBUTYL-1-METHYLXANTHINEnon-polymer222.25Chemie (IBM)
6waterwater18.017Chemie (HOH)
Sequence modifications
A, B: 535 - 786 (UniProt: O76074)
PDBExternal DatabaseDetails
Gly 531-expression tag
Ser 532-expression tag
His 533-expression tag
Met 534-expression tag
A, B: 787 - 826 (UniProt: P51160)
A, B: 827 - 860 (UniProt: O76074)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight80935.0
Non-Polymers*Number of molecules9
Total formula weight1290.6
All*Total formula weight82225.7
*Water molecules are not included.

222036

PDB entries from 2024-07-03

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