3JWR
Crystal structure of chimeric PDE5/PDE6 catalytic domain complexed with 3-isobutyl-1-methylxanthine (IBMX) and PDE6 gamma-subunit inhibitory peptide 70-87.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | cGMP-specific 3',5'-cyclic phosphodiesterase catalytic domain, Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha chimera | polymer | 330 | 38282.1 | 2 | UniProt (O76074) UniProt (P51160) Pfam (PF00233) In PDB | Homo sapiens | cGMP-binding cGMP-specific phosphodiesterase, CGB-PDE, cGMP phosphodiesterase 6C |
2 | C, D | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma | polymer | 18 | 2185.4 | 2 | UniProt (P18545) In PDB | Homo sapiens | GMP-PDE gamma |
3 | A, B | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
4 | A, B | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
5 | A, B | 3-ISOBUTYL-1-METHYLXANTHINE | non-polymer | 222.2 | 5 | Chemie (IBM) | |||
6 | water | water | 18.0 | 17 | Chemie (HOH) |
Sequence modifications
A, B: 535 - 786 (UniProt: O76074)
A, B: 787 - 826 (UniProt: P51160)
A, B: 827 - 860 (UniProt: O76074)
PDB | External Database | Details |
---|---|---|
Gly 531 | - | expression tag |
Ser 532 | - | expression tag |
His 533 | - | expression tag |
Met 534 | - | expression tag |
A, B: 827 - 860 (UniProt: O76074)
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 80935.0 | |
Non-Polymers* | Number of molecules | 9 |
Total formula weight | 1290.6 | |
All* | Total formula weight | 82225.7 |