3JWQ

Crystal structure of chimeric PDE5/PDE6 catalytic domain complexed with sildenafil

Summary for 3JWQ

• Entry DOI: 10.2210/pdb3jwq/pdb
• Related: 3JWR
• Descriptor: cGMP-specific 3',5'-cyclic phosphodiesterase catalytic domain, Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha chimera, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: mostly alpha, allosteric enzyme, cgmp, cgmp-binding, hydrolase, magnesium, metal-binding, nucleotide-binding, phosphoprotein, cell membrane, lipoprotein, membrane, methylation, prenylation, sensory transduction, vision
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 155385.50

Authors

Barren, B.,Gakhar, L.,Muradov, H.,Boyd, K.K.,Ramaswamy, S.,Artemyev, N.O. (deposition date: 2009-09-18, release date: 2009-10-13, Last modification date: 2023-09-06)

• Primary citation: Barren, B.,Gakhar, L.,Muradov, H.,Boyd, K.K.,Ramaswamy, S.,Artemyev, N.O.; Structural basis of phosphodiesterase 6 inhibition by the C-terminal region of the gamma-subunit; Embo J., 28:3613-3622, 2009; PubMed: 19798052; DOI: 10.1038/emboj.2009.284

Experimental method

X-RAY DIFFRACTION (2.87 Å)