3JWQ
Crystal structure of chimeric PDE5/PDE6 catalytic domain complexed with sildenafil
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| A | 0007165 | biological_process | signal transduction |
| A | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| B | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| B | 0007165 | biological_process | signal transduction |
| B | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| C | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| C | 0007165 | biological_process | signal transduction |
| C | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| D | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| D | 0007165 | biological_process | signal transduction |
| D | 0008081 | molecular_function | phosphoric diester hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN A 899 |
| Chain | Residue |
| A | HOH6 |
| A | HIS617 |
| A | HIS653 |
| A | ASP654 |
| A | ASP764 |
| A | MG900 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG A 900 |
| Chain | Residue |
| A | HOH8 |
| A | ASP654 |
| A | THR723 |
| A | ZN899 |
| A | HOH4 |
| A | HOH6 |
| A | HOH7 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE VIA A 901 |
| Chain | Residue |
| A | TYR612 |
| A | MET804 |
| A | GLN817 |
| A | PHE820 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN B 899 |
| Chain | Residue |
| B | HIS617 |
| B | HIS653 |
| B | ASP654 |
| B | ASP764 |
| B | MG900 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG B 900 |
| Chain | Residue |
| B | HOH1 |
| B | HOH11 |
| B | HOH12 |
| B | ASP654 |
| B | GLU682 |
| B | THR723 |
| B | ZN899 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE VIA B 901 |
| Chain | Residue |
| B | HIS613 |
| B | VAL782 |
| B | PHE786 |
| B | MET804 |
| B | LEU813 |
| B | GLN817 |
| B | PHE820 |
| C | ARG794 |
| C | THR795 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 899 |
| Chain | Residue |
| C | HIS617 |
| C | HIS653 |
| C | ASP654 |
| C | ASP764 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG C 900 |
| Chain | Residue |
| C | HOH3 |
| C | HOH13 |
| C | HOH14 |
| C | ASP654 |
| C | GLU682 |
| C | THR723 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE VIA C 901 |
| Chain | Residue |
| C | TYR612 |
| C | PHE786 |
| C | MET804 |
| C | GLN817 |
| C | PHE820 |
| C | VAL824 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN D 899 |
| Chain | Residue |
| D | HIS617 |
| D | HIS653 |
| D | ASP654 |
| D | ASP764 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG D 900 |
| Chain | Residue |
| D | HOH5 |
| D | ASP654 |
| D | GLU682 |
| D | THR723 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE VIA D 901 |
| Chain | Residue |
| A | ARG794 |
| D | TYR612 |
| D | MET804 |
| D | GLN817 |
| D | PHE820 |
Functional Information from PROSITE/UniProt
| site_id | PS00126 |
| Number of Residues | 12 |
| Details | PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHrGvnNsY |
| Chain | Residue | Details |
| A | HIS653-TYR664 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton donor => ECO:0000250|UniProtKB:O76083 |
| Chain | Residue | Details |
| A | HIS613 | |
| B | HIS613 | |
| C | HIS613 | |
| D | HIS613 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:12955149, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1T9R, ECO:0007744|PDB:1T9S, ECO:0007744|PDB:1TBF |
| Chain | Residue | Details |
| A | HIS617 | |
| C | HIS653 | |
| C | ASP654 | |
| C | ASP764 | |
| D | HIS617 | |
| D | HIS653 | |
| D | ASP654 | |
| D | ASP764 | |
| A | HIS653 | |
| A | ASP654 | |
| A | ASP764 | |
| B | HIS617 | |
| B | HIS653 | |
| B | ASP654 | |
| B | ASP764 | |
| C | HIS617 |
