3JWQ
Crystal structure of chimeric PDE5/PDE6 catalytic domain complexed with sildenafil
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | cGMP-specific 3',5'-cyclic phosphodiesterase catalytic domain, Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha chimera | polymer | 330 | 38282.1 | 4 | UniProt (O76074) UniProt (P51160) Pfam (PF00233) In PDB | Homo sapiens (human) | cGMP-binding cGMP-specific phosphodiesterase, CGB-PDE, cGMP phosphodiesterase 6C |
2 | A, B, C, D | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
3 | A, B, C, D | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
4 | A, B, C, D | 5-{2-ETHOXY-5-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-1-METHYL-3-PROPYL-1H,6H,7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE | non-polymer | 474.6 | 4 | Chemie (VIA) | |||
5 | water | water | 18.0 | 13 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 535 - 786 (UniProt: O76074)
A, B, C, D: 787 - 826 (UniProt: P51160)
A, B, C, D: 827 - 860 (UniProt: O76074)
PDB | External Database | Details |
---|---|---|
Gly 531 | - | expression tag |
Ser 532 | - | expression tag |
His 533 | - | expression tag |
Met 534 | - | expression tag |
A, B, C, D: 827 - 860 (UniProt: O76074)
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 153128.3 | |
Non-Polymers* | Number of molecules | 12 |
Total formula weight | 2257.2 | |
All* | Total formula weight | 155385.5 |