1KI0
| The X-ray Structure of Human Angiostatin | 分子名称: | ANGIOSTATIN, BICINE | 著者 | Abad, M.C, Arni, R.K, Grella, D.K, Castellino, F.J, Tulinsky, A, Geiger, J.H. | 登録日 | 2001-12-02 | 公開日 | 2002-05-29 | 最終更新日 | 2021-10-27 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | The X-ray crystallographic structure of the angiogenesis inhibitor angiostatin. J.Mol.Biol., 318, 2002
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2P7G
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2P7A
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2P7Z
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1M7X
| The X-ray Crystallographic Structure of Branching Enzyme | 分子名称: | 1,4-alpha-glucan Branching Enzyme | 著者 | Abad, M.C, Binderup, K, Rios-Steiner, J, Arni, R.K, Preiss, J, Geiger, J.H. | 登録日 | 2002-07-23 | 公開日 | 2002-09-18 | 最終更新日 | 2022-12-21 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | The X-ray crystallographic structure of Escherichia coli branching enzyme J.Biol.Chem., 277, 2002
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3BEL
| X-ray structure of EGFR in complex with oxime inhibitor | 分子名称: | 4-amino-6-{[1-(3-fluorobenzyl)-1H-indazol-5-yl]amino}pyrimidine-5-carbaldehyde O-(2-methoxyethyl)oxime, Epidermal growth factor receptor, PHOSPHATE ION | 著者 | Abad, M.C, Xu, G, Neeper, M.P, Struble, G.T, Gaul, M.D, Connolly, P.J. | 登録日 | 2007-11-19 | 公開日 | 2008-07-01 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Discovery of novel 4-amino-6-arylaminopyrimidine-5-carbaldehyde oximes as dual inhibitors of EGFR and ErbB-2 protein tyrosine kinases. Bioorg.Med.Chem.Lett., 18, 2008
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3K6P
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2RA0
| X-ray Structure of FXa in complex with 7-fluoroindazole | 分子名称: | 1-(3-amino-1,2-benzisoxazol-5-yl)-6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}-2-fluorophenyl)-7-fluoro-1H-indazole-3-carboxamide, Coagulation factor X | 著者 | Abad, M.C. | 登録日 | 2007-09-14 | 公開日 | 2008-01-29 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | 7-fluoroindazoles as potent and selective inhibitors of factor xa. J.Med.Chem., 51, 2008
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2RGP
| Structure of EGFR in complex with hydrazone, a potent dual inhibitor | 分子名称: | Epidermal growth factor receptor, N-[1-(3-fluorobenzyl)-1H-indazol-5-yl]-5-[(piperidin-1-ylamino)methyl]pyrimidine-4,6-diamine, PHOSPHATE ION | 著者 | Abad, M.C. | 登録日 | 2007-10-04 | 公開日 | 2008-08-26 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | 4-Amino-6-arylamino-pyrimidine-5-carbaldehyde hydrazones as potent ErbB-2/EGFR dual kinase inhibitors. Bioorg.Med.Chem.Lett., 18, 2008
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3NBW
| X-ray structure of ketohexokinase in complex with a pyrazole compound | 分子名称: | 5-amino-3-(methylsulfanyl)-1-phenyl-1H-pyrazole-4-carbonitrile, GLYCEROL, Ketohexokinase, ... | 著者 | Abad, M.C, Gibbs, A.C, Spurlino, J.C. | 登録日 | 2010-06-04 | 公開日 | 2010-12-22 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.341 Å) | 主引用文献 | Electron density guided fragment-based lead discovery of ketohexokinase inhibitors. J.Med.Chem., 53, 2010
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3NC2
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3NC9
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3N7O
| X-ray structure of human chymase in complex with small molecule inhibitor. | 分子名称: | (S)-[(1S)-1-(5-chloro-1-benzothiophen-3-yl)-2-{[(E)-2-(3,4-difluorophenyl)ethenyl]amino}-2-oxoethyl]methylphosphinic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Chymase, ... | 著者 | Abad, M.C, Kervinen, J, Crysler, C, Bayoumy, S, Spurlino, J, Deckman, I, Greco, M.N, Maryanoff, B.E, Degaravilla, L. | 登録日 | 2010-05-27 | 公開日 | 2010-07-21 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Potency variation of small-molecule chymase inhibitors across species. Biochem. Pharmacol., 80, 2010
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3NCA
| X-ray structure of ketohexokinase in complex with a thieno pyridinol compound | 分子名称: | Ketohexokinase, SULFATE ION, thieno[3,2-b]pyridin-7-ol | 著者 | Abad, M.C, Gibbs, A.C, Spurlino, J.C. | 登録日 | 2010-06-04 | 公開日 | 2010-12-22 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.602 Å) | 主引用文献 | Electron density guided fragment-based lead discovery of ketohexokinase inhibitors. J.Med.Chem., 53, 2010
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3NBV
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3Q92
| X-ray Structure of ketohexokinase in complex with a pyrimidopyrimidine analog 1 | 分子名称: | Ketohexokinase, N~8~-(cyclopropylmethyl)-N~4~-[2-(methylsulfanyl)phenyl]-2-(piperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine, SULFATE ION | 著者 | Abad, M.C. | 登録日 | 2011-01-07 | 公開日 | 2012-01-18 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Inhibitors of Ketohexokinase: Discovery of Pyrimidinopyrimidines with Specific Substitution that Complements the ATP-Binding Site. ACS Med Chem Lett, 2, 2011
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3QA2
| X-ray Structure of ketohexokinase in complex with a pyrimidopyrimidine analog 2 | 分子名称: | Ketohexokinase, N~8~-(cyclopropylmethyl)-N~4~-(2-methylphenyl)-2-(piperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine, SULFATE ION | 著者 | Abad, M.C. | 登録日 | 2011-01-10 | 公開日 | 2012-01-18 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.519 Å) | 主引用文献 | Inhibitors of Ketohexokinase: Discovery of Pyrimidinopyrimidines with Specific Substitution that Complements the ATP-Binding Site. ACS Med Chem Lett, 2, 2011
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3RO4
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3QAI
| X-ray Structure of ketohexokinase in complex with a pyrimidopyrimidine analog 3 | 分子名称: | Ketohexokinase, N~8~-(cyclopropylmethyl)-2-(2,6-diazaspiro[3.3]hept-2-yl)-N~4~-[2-(methylsulfanyl)phenyl]pyrimido[5,4-d]pyrimidine-4,8-diamine, SULFATE ION | 著者 | Abad, M.C. | 登録日 | 2011-01-11 | 公開日 | 2012-01-18 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Inhibitors of Ketohexokinase: Discovery of Pyrimidinopyrimidines with Specific Substitution that Complements the ATP-Binding Site. ACS Med Chem Lett, 2, 2011
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2AJL
| X-ray Structure of Novel Biaryl-Based Dipeptidyl peptidase IV inhibitor | 分子名称: | 1-[2-(S)-AMINO-3-BIPHENYL-4-YL-PROPIONYL]-PYRROLIDINE-2-(S)-CARBONITRILE, 2-acetamido-2-deoxy-beta-D-glucopyranose, Dipeptidyl peptidase 4 | 著者 | Qiao, L, Baumann, C.A, Crysler, C.S, Ninan, N.S, Abad, M.C, Spurlino, J.C, DesJarlais, R.L, Kervinen, J, Neeper, M.P, Bayoumy, S.S. | 登録日 | 2005-08-02 | 公開日 | 2005-11-08 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Discovery, SAR, and X-ray structure of novel biaryl-based dipeptidyl peptidase IV inhibitors Bioorg.Med.Chem.Lett., 16, 2006
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