2RA0
X-ray Structure of FXa in complex with 7-fluoroindazole
Summary for 2RA0
Entry DOI | 10.2210/pdb2ra0/pdb |
Descriptor | Coagulation factor X, 1-(3-amino-1,2-benzisoxazol-5-yl)-6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}-2-fluorophenyl)-7-fluoro-1H-indazole-3-carboxamide, ... (4 entities in total) |
Functional Keywords | serine protease, blood coagulation, calcium, cleavage on pair of basic residues, egf-like domain, gamma-carboxyglutamic acid, glycoprotein, hydrolase, hydroxylation, polymorphism, zymogen |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P00742 P00742 |
Total number of polymer chains | 2 |
Total formula weight | 32421.64 |
Authors | Abad, M.C. (deposition date: 2007-09-14, release date: 2008-01-29, Last modification date: 2021-10-20) |
Primary citation | Lee, Y.K.,Parks, D.J.,Lu, T.,Thieu, T.V.,Markotan, T.,Pan, W.,McComsey, D.F.,Milkiewicz, K.L.,Crysler, C.S.,Ninan, N.,Abad, M.C.,Giardino, E.C.,Maryanoff, B.E.,Damiano, B.P.,Player, M.R. 7-fluoroindazoles as potent and selective inhibitors of factor xa. J.Med.Chem., 51:282-297, 2008 Cited by PubMed: 18159923DOI: 10.1021/jm701217r PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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