2RA0
X-ray Structure of FXa in complex with 7-fluoroindazole
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Coagulation factor X | polymer | 234 | 26447.1 | 1 | UniProt (P00742) Pfam (PF00089) In PDB | Homo sapiens (human) | Stuart factor, Stuart-Prower factor |
| 2 | L | Coagulation factor X | polymer | 51 | 5446.0 | 1 | UniProt (P00742) Pfam (PF14670) In PDB | Homo sapiens (human) | Stuart factor, Stuart-Prower factor |
| 3 | A | 1-(3-amino-1,2-benzisoxazol-5-yl)-6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}-2-fluorophenyl)-7-fluoro-1H-indazole-3-carboxamide | non-polymer | 528.5 | 1 | Chemie (JNJ) | |||
| 4 | water | water | 18.0 | 81 | Chemie (HOH) |
Sequence modifications
L: 88 - 138 (UniProt: P00742)
| PDB | External Database | Details |
|---|---|---|
| Val 88 | Leu 128 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 31893.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 528.5 | |
| All* | Total formula weight | 32421.6 |
