3N7O

X-ray structure of human chymase in complex with small molecule inhibitor.

Summary for 3N7O

Entry DOI	10.2210/pdb3n7o/pdb
Descriptor	Chymase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, (S)-[(1S)-1-(5-chloro-1-benzothiophen-3-yl)-2-{[(E)-2-(3,4-difluorophenyl)ethenyl]amino}-2-oxoethyl]methylphosphinic acid, ... (5 entities in total)
Functional Keywords	serine protease, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	26300.47
Authors	Abad, M.C.,Kervinen, J.,Crysler, C.,Bayoumy, S.,Spurlino, J.,Deckman, I.,Greco, M.N.,Maryanoff, B.E.,Degaravilla, L. (deposition date: 2010-05-27, release date: 2010-07-21, Last modification date: 2023-09-06)
Primary citation	Kervinen, J.,Crysler, C.,Bayoumy, S.,Abad, M.C.,Spurlino, J.,Deckman, I.,Greco, M.N.,Maryanoff, B.E.,de Garavilla, L. Potency variation of small-molecule chymase inhibitors across species. Biochem. Pharmacol., 80:1033-1041, 2010 Cited by PubMed: 20599788 DOI: 10.1016/j.bcp.2010.06.014 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation