6DI4
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6DKJ
| human GIPR ECD and Fab complex | 分子名称: | 1,2-ETHANEDIOL, Fab heavy chain, Fab light chain, ... | 著者 | Min, X, Wang, Z. | 登録日 | 2018-05-29 | 公開日 | 2019-05-08 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Anti-obesity effects of GIPR antagonists alone and in combination with GLP-1R agonists in preclinical models. Sci Transl Med, 10, 2018
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6EEB
| Calmodulin in complex with malbrancheamide | 分子名称: | (5aS,12aS,13aS)-8,9-dichloro-12,12-dimethyl-2,3,11,12,12a,13-hexahydro-1H,5H,6H-5a,13a-(epiminomethano)indolizino[7,6-b]carbazol-14-one, CALCIUM ION, Calmodulin-1, ... | 著者 | Beyett, T.S, Fraley, A.E, Tesmer, J.J.G. | 登録日 | 2018-08-13 | 公開日 | 2019-08-07 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | Perturbation of the interactions of calmodulin with GRK5 using a natural product chemical probe. Proc.Natl.Acad.Sci.USA, 116, 2019
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7RBT
| cryo-EM structure of human Gastric inhibitory polypeptide receptor GIPR bound to tirzepatide | 分子名称: | 2-fluoro-4-[(1R)-6-methoxy-1-methyl-2-{(1S)-1-[4-(propan-2-yl)phenyl]ethyl}-1,2,3,4-tetrahydroisoquinolin-5-yl]-6-[(2-methylpropyl)amino]phenol, Gastric inhibitory polypeptide receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Sun, B, Kobilka, B.K, Sloop, K.W, Feng, D, Kobilka, T.S. | 登録日 | 2021-07-06 | 公開日 | 2022-04-13 | 実験手法 | ELECTRON MICROSCOPY (3.08 Å) | 主引用文献 | Structural determinants of dual incretin receptor agonism by tirzepatide. Proc.Natl.Acad.Sci.USA, 119, 2022
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7RA3
| cryo-EM of human Gastric inhibitory polypeptide receptor GIPR bound to GIP | 分子名称: | Gastric inhibitory polypeptide, Gastric inhibitory polypeptide receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Sun, B, Kobilka, B.K, Sloop, K.W, Feng, D, Kobilka, T.S. | 登録日 | 2021-06-29 | 公開日 | 2022-04-13 | 実験手法 | ELECTRON MICROSCOPY (3.24 Å) | 主引用文献 | Structural determinants of dual incretin receptor agonism by tirzepatide. Proc.Natl.Acad.Sci.USA, 119, 2022
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7RGP
| cryo-EM of human Glucagon-like peptide 1 receptor GLP-1R bound to tirzepatide | 分子名称: | Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Sun, B, Kobilka, B.K, Sloop, K.W, Feng, D, Kobilka, T.S. | 登録日 | 2021-07-15 | 公開日 | 2022-04-13 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural determinants of dual incretin receptor agonism by tirzepatide. Proc.Natl.Acad.Sci.USA, 119, 2022
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7RG9
| cryo-EM of human Glucagon-like peptide 1 receptor GLP-1R in apo form | 分子名称: | Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Sun, B, Kobilka, B.K, Sloop, K.W, Feng, D, Kobilka, T.S. | 登録日 | 2021-07-14 | 公開日 | 2022-04-13 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural determinants of dual incretin receptor agonism by tirzepatide. Proc.Natl.Acad.Sci.USA, 119, 2022
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7U6E
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7U6D
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5URC
| Design, Synthesis, Functional and Biological Evaluation of Ether and Ester Derivatives of the Antisickling Agent 5-HMF for the Treatment of Sickle Cell Disease | 分子名称: | (5-formylfuran-2-yl)methyl acetate, 5-HYDROXYMETHYL-FURFURAL, CARBON MONOXIDE, ... | 著者 | Pagare, P.P, Safo, R.S, Gazi, A. | 登録日 | 2017-02-10 | 公開日 | 2017-03-15 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Design, Synthesis, and Biological Evaluation of Ester and Ether Derivatives of Antisickling Agent 5-HMF for the Treatment of Sickle Cell Disease. Mol. Pharm., 14, 2017
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7EUO
| The structure of formyl peptide receptor 1 in complex with Gi and peptide agonist fMLF | 分子名称: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Wang, X.K, Chen, G, Liao, Q.W, Du, Y, Hu, H.L, Ye, D.Q. | 登録日 | 2021-05-18 | 公開日 | 2022-05-25 | 最終更新日 | 2022-12-07 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural basis for recognition of N-formyl peptides as pathogen-associated molecular patterns. Nat Commun, 13, 2022
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5ZVS
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7YE9
| SARS-CoV-2 Spike (6P) in complex with 3 R1-32 Fabs | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of R1-32 Fab, ... | 著者 | Liu, B, Gao, X, Li, Z, Chen, X, He, J, Chen, L, Xiong, X. | 登録日 | 2022-07-05 | 公開日 | 2022-08-24 | 最終更新日 | 2023-05-03 | 実験手法 | ELECTRON MICROSCOPY (4.17 Å) | 主引用文献 | SARS-CoV-2 Delta and Omicron variants evade population antibody response by mutations in a single spike epitope. Nat Microbiol, 7, 2022
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5ZVT
| Structure of RNA polymerase complex and genome within a dsRNA virus provides insights into the mechanisms of transcription and assembly | 分子名称: | C-terminus of outer capsid protein VP5, Core protein VP6, MYRISTIC ACID, ... | 著者 | Liu, H, Fang, Q, Cheng, L. | 登録日 | 2018-05-12 | 公開日 | 2018-07-04 | 最終更新日 | 2018-07-25 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structure of RNA polymerase complex and genome within a dsRNA virus provides insights into the mechanisms of transcription and assembly. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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7YEG
| SARS-CoV-2 Spike (6P) in complex with 3 R1-32 Fabs and 3 ACE2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... | 著者 | Liu, B, Gao, X, Li, Z, Chen, X, He, J, Chen, L, Xiong, X. | 登録日 | 2022-07-05 | 公開日 | 2022-08-24 | 最終更新日 | 2023-07-26 | 実験手法 | ELECTRON MICROSCOPY (3.73 Å) | 主引用文献 | SARS-CoV-2 Delta and Omicron variants evade population antibody response by mutations in a single spike epitope. Nat Microbiol, 7, 2022
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7YDY
| SARS-CoV-2 Spike (6P) in complex with 1 R1-32 Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of R1-32 Fab, ... | 著者 | Liu, B, Gao, X, Li, Z, Chen, X, He, J, Chen, L, Xiong, X. | 登録日 | 2022-07-04 | 公開日 | 2022-08-24 | 最終更新日 | 2023-07-26 | 実験手法 | ELECTRON MICROSCOPY (4.75 Å) | 主引用文献 | SARS-CoV-2 Delta and Omicron variants evade population antibody response by mutations in a single spike epitope. Nat Microbiol, 7, 2022
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7YDI
| SARS-CoV-2 Spike (6P) in complex with 3 R1-32 Fabs and 3 ACE2, focused refinement of RBD region | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of R1-32, Light chain of R1-32, ... | 著者 | Liu, B, Gao, X, Li, Z, Chen, X, He, J, Chen, L, Xiong, X. | 登録日 | 2022-07-04 | 公開日 | 2022-08-24 | 最終更新日 | 2023-07-26 | 実験手法 | ELECTRON MICROSCOPY (3.98 Å) | 主引用文献 | SARS-CoV-2 Delta and Omicron variants evade population antibody response by mutations in a single spike epitope. Nat Microbiol, 7, 2022
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7YE5
| SARS-CoV-2 Spike (6P) in complex with 2 R1-32 Fabs | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of R1-32 Fab, ... | 著者 | Liu, B, Gao, X, Li, Z, Chen, X, He, J, Chen, L, Xiong, X. | 登録日 | 2022-07-05 | 公開日 | 2022-08-24 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (6.75 Å) | 主引用文献 | SARS-CoV-2 Delta and Omicron variants evade population antibody response by mutations in a single spike epitope. Nat Microbiol, 7, 2022
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5XM6
| the overall structure of VrEH2 | 分子名称: | Epoxide hydrolase | 著者 | Li, F.L, Kong, X.D, Yu, H.L, Shang, Y.P, Zhou, J.H, Xu, J.H. | 登録日 | 2017-05-12 | 公開日 | 2018-09-05 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.501 Å) | 主引用文献 | Regioselectivity Engineering of Epoxide Hydrolase: Near-Perfect Enantioconvergence through a Single Site Mutation Acs Catalysis, 8, 2018
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2N9X
| LC3 FUNDC1 complex structure | 分子名称: | FUN14 domain-containing protein 1, Microtubule-associated proteins 1A/1B light chain 3B | 著者 | Xia, B, Kuang, Y. | 登録日 | 2015-12-14 | 公開日 | 2016-12-14 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural basis for the phosphorylation of FUNDC1 LIR as a molecular switch of mitophagy. Autophagy, 12, 2016
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7E5Y
| Molecular basis for neutralizing antibody 2B11 targeting SARS-CoV-2 RBD | 分子名称: | 2B11 Fab Heavy chain, 2B11 Fab Light chain, Spike protein S1 | 著者 | Wu, H, Yu, F, Wang, Q.S, Zhou, H, Wang, W.W, Zhao, T, Pan, Y.B, Yang, X.M. | 登録日 | 2021-02-21 | 公開日 | 2021-06-23 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.59 Å) | 主引用文献 | Screening of potent neutralizing antibodies against SARS-CoV-2 using convalescent patients-derived phage-display libraries. Cell Discov, 7, 2021
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6M3M
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7FDG
| SARS-COV-2 Spike RBDMACSp6 binding to hACE2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, Spike protein S1 | 著者 | Wang, X, Cao, L. | 登録日 | 2021-07-16 | 公開日 | 2021-08-25 | 最終更新日 | 2022-03-23 | 実験手法 | ELECTRON MICROSCOPY (3.69 Å) | 主引用文献 | Characterization and structural basis of a lethal mouse-adapted SARS-CoV-2. Nat Commun, 12, 2021
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7FDI
| SARS-COV-2 Spike RBDMACSp36 binding to hACE2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, Spike protein S1 | 著者 | Wang, X, Cao, L. | 登録日 | 2021-07-16 | 公開日 | 2021-08-25 | 最終更新日 | 2022-03-23 | 実験手法 | ELECTRON MICROSCOPY (3.12 Å) | 主引用文献 | Characterization and structural basis of a lethal mouse-adapted SARS-CoV-2. Nat Commun, 12, 2021
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7FDH
| SARS-COV-2 Spike RBDMACSp25 binding to hACE2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, Spike protein S1 | 著者 | Wang, X, Cao, L. | 登録日 | 2021-07-16 | 公開日 | 2021-08-25 | 最終更新日 | 2022-03-23 | 実験手法 | ELECTRON MICROSCOPY (3.72 Å) | 主引用文献 | Characterization and structural basis of a lethal mouse-adapted SARS-CoV-2. Nat Commun, 12, 2021
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