6LS4
| A novel anti-tumor agent S-40 in complex with tubulin | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-[(4-cyclopropylphenyl)sulfonylamino]-4-methyl-N-(pyridin-3-ylmethyl)benzamide, GLYCEROL, ... | Authors: | Du, T, Lin, S, Ji, M, Xue, N, Liu, Y, Zhang, K, Lu, D, Chen, X, Xu, H. | Deposit date: | 2020-01-17 | Release date: | 2021-01-20 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | A novel orally active microtubule destabilizing agent S-40 targets the colchicine-binding site and shows potent antitumor activity. Cancer Lett., 495, 2020
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8J72
| Crystal structure of mammalian Trim71 in complex with lncRNA Trincr1 | Descriptor: | E3 ubiquitin-protein ligase TRIM71, lncRNA Trincr1 | Authors: | Shi, F.D, Zhang, K, Che, S.Y, Zhi, S.X, Yang, N. | Deposit date: | 2023-04-27 | Release date: | 2024-03-06 | Method: | X-RAY DIFFRACTION (3.16 Å) | Cite: | Molecular mechanism governing RNA-binding property of mammalian TRIM71 protein. Sci Bull (Beijing), 69, 2024
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8K3Y
| The "5+1" heteromeric structure of Lon protease consisting of a spiral pentamer with Y224S mutation and an N-terminal-truncated monomeric E613K mutant | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Lon protease | Authors: | Li, S, Hsieh, K.Y, Kuo, C.I, Zhang, K, Chang, C.I. | Deposit date: | 2023-07-17 | Release date: | 2023-10-25 | Last modified: | 2023-11-29 | Method: | ELECTRON MICROSCOPY (4.42 Å) | Cite: | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine. Nat Commun, 14, 2023
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7YCG
| Cryo-EM structure of Tetrahymena ribozyme conformation 2 undergoing the first-step self-splicing | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, RNA (393-MER), ... | Authors: | Zhang, X, Li, S, Pintilie, G, Palo, M.Z, Zhang, K. | Deposit date: | 2022-07-01 | Release date: | 2023-07-05 | Last modified: | 2023-08-16 | Method: | ELECTRON MICROSCOPY (3.18 Å) | Cite: | Snapshots of the first-step self-splicing of Tetrahymena ribozyme revealed by cryo-EM. Nucleic Acids Res., 51, 2023
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7YC8
| Cryo-EM structure of Tetrahymena ribozyme conformation 1 undergoing the first-step self-splicing | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, RNA (388-MER) | Authors: | Zhang, X, Li, S, Pintilie, G, Palo, M.Z, Zhang, K. | Deposit date: | 2022-07-01 | Release date: | 2023-07-05 | Last modified: | 2023-08-16 | Method: | ELECTRON MICROSCOPY (4.14 Å) | Cite: | Snapshots of the first-step self-splicing of Tetrahymena ribozyme revealed by cryo-EM. Nucleic Acids Res., 51, 2023
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7YCI
| Cryo-EM structure of Tetrahymena ribozyme conformation 4 undergoing the first-step self-splicing | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, RNA (389-MER), ... | Authors: | Zhang, X, Li, S, Pintilie, G, Palo, M.Z, Zhang, K. | Deposit date: | 2022-07-01 | Release date: | 2023-07-05 | Last modified: | 2023-08-16 | Method: | ELECTRON MICROSCOPY (2.98 Å) | Cite: | Snapshots of the first-step self-splicing of Tetrahymena ribozyme revealed by cryo-EM. Nucleic Acids Res., 51, 2023
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7YCH
| Cryo-EM structure of Tetrahymena ribozyme conformation 3 undergoing the first-step self-splicing | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, RNA (393-MER), ... | Authors: | Zhang, X, Li, S, Pintilie, G, Palo, M.Z, Zhang, K. | Deposit date: | 2022-07-01 | Release date: | 2023-07-05 | Last modified: | 2023-08-16 | Method: | ELECTRON MICROSCOPY (3.09 Å) | Cite: | Snapshots of the first-step self-splicing of Tetrahymena ribozyme revealed by cryo-EM. Nucleic Acids Res., 51, 2023
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7YGA
| Cryo-EM structure of Tetrahymena ribozyme conformation 2 undergoing the second-step self-splicing | Descriptor: | MAGNESIUM ION, RNA (393-MER), RNA (5'-R(*CP*CP*CP*UP*CP*U)-3'), ... | Authors: | Li, S, Michael, Z.P, Zhang, X, Greg, P, Zhang, K. | Deposit date: | 2022-07-11 | Release date: | 2023-03-29 | Method: | ELECTRON MICROSCOPY (2.35 Å) | Cite: | Snapshots of the second-step self-splicing of Tetrahymena ribozyme revealed by cryo-EM. Nat Commun, 14, 2023
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7YGD
| Cryo-EM structure of Tetrahymena ribozyme conformation 6 undergoing the second-step self-splicing | Descriptor: | MAGNESIUM ION, RNA (384-MER), RNA (5'-R(*CP*C)-3'), ... | Authors: | Li, S, Michael, Z.P, Zhang, X, Greg, P, Zhang, K. | Deposit date: | 2022-07-11 | Release date: | 2023-03-29 | Method: | ELECTRON MICROSCOPY (3.41 Å) | Cite: | Snapshots of the second-step self-splicing of Tetrahymena ribozyme revealed by cryo-EM. Nat Commun, 14, 2023
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7YG9
| Cryo-EM structure of Tetrahymena ribozyme conformation 1 undergoing the second-step self-splicing | Descriptor: | MAGNESIUM ION, RNA (391-MER), RNA (5'-R(*CP*CP*CP*UP*CP*U)-3'), ... | Authors: | Li, S, Michael, Z.P, Zhang, X, Greg, P, Zhang, K. | Deposit date: | 2022-07-11 | Release date: | 2023-03-29 | Method: | ELECTRON MICROSCOPY (2.68 Å) | Cite: | Snapshots of the second-step self-splicing of Tetrahymena ribozyme revealed by cryo-EM. Nat Commun, 14, 2023
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7YGC
| Cryo-EM structure of Tetrahymena ribozyme conformation 4 undergoing the second-step self-splicing | Descriptor: | MAGNESIUM ION, RNA (393-MER), RNA (5'-R(*CP*CP*CP*UP*CP*UP*UP*AP*AP*CP*C)-3'), ... | Authors: | Li, S, Michael, Z.P, Zhang, X, Greg, P, Zhang, K. | Deposit date: | 2022-07-11 | Release date: | 2023-03-29 | Last modified: | 2023-04-05 | Method: | ELECTRON MICROSCOPY (2.65 Å) | Cite: | Snapshots of the second-step self-splicing of Tetrahymena ribozyme revealed by cryo-EM. Nat Commun, 14, 2023
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7YG8
| Cryo-EM structure of Tetrahymena ribozyme conformation 5 undergoing the second-step self-splicing | Descriptor: | MAGNESIUM ION, RNA (387-MER), RNA (5'-R(*CP*CP*CP*UP*C)-3'), ... | Authors: | Li, S, Michael, Z.P, Zhang, X, Greg, P, Zhang, K. | Deposit date: | 2022-07-11 | Release date: | 2023-03-29 | Method: | ELECTRON MICROSCOPY (2.97 Å) | Cite: | Snapshots of the second-step self-splicing of Tetrahymena ribozyme revealed by cryo-EM. Nat Commun, 14, 2023
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7YGB
| Cryo-EM structure of Tetrahymena ribozyme conformation 3 undergoing the second-step self-splicing | Descriptor: | MAGNESIUM ION, RNA (393-MER), RNA (5'-R(*CP*CP*CP*UP*CP*UP*UP*AP*AP*CP*C)-3'), ... | Authors: | Li, S, Michael, Z.P, Zhang, X, Greg, P, Zhang, K. | Deposit date: | 2022-07-11 | Release date: | 2023-03-29 | Method: | ELECTRON MICROSCOPY (2.62 Å) | Cite: | Snapshots of the second-step self-splicing of Tetrahymena ribozyme revealed by cryo-EM. Nat Commun, 14, 2023
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7FD4
| A complete three-dimensional structure of the Lon protease translocating a protein substrate (conformation 1) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Alpha-S1-casein, Lon protease, ... | Authors: | Li, S, Hsieh, K, Kuo, C, Lee, S, Pintilie, G, Zhang, K, Chang, C. | Deposit date: | 2021-07-16 | Release date: | 2021-11-03 | Method: | ELECTRON MICROSCOPY (2.4 Å) | Cite: | Complete three-dimensional structures of the Lon protease translocating a protein substrate. Sci Adv, 7, 2021
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7FD5
| A complete three-dimensional structure of the Lon protease translocating a protein substrate (conformation 2) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Alpha-S1-casein, Lon protease, ... | Authors: | Li, S, Hsieh, K, Kuo, C, Lee, S, Pintilie, G, Zhang, K, Chang, C. | Deposit date: | 2021-07-16 | Release date: | 2021-11-03 | Method: | ELECTRON MICROSCOPY (2.4 Å) | Cite: | Complete three-dimensional structures of the Lon protease translocating a protein substrate. Sci Adv, 7, 2021
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7EVP
| Cryo-EM structure of the Gp168-beta-clamp complex | Descriptor: | Beta sliding clamp, Sliding clamp inhibitor | Authors: | Liu, B, Li, S, Liu, Y, Chen, H, Hu, Z, Wang, Z, Gou, L, Zhang, L, Ma, B, Wang, H, Matthews, S, Wang, Y, Zhang, K. | Deposit date: | 2021-05-21 | Release date: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Bacteriophage Twort protein Gp168 is a beta-clamp inhibitor by occupying the DNA sliding channel. Nucleic Acids Res., 49, 2021
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7XDT
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7XGR
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7YHN
| ANTI-TUMOR AGENT Y48 IN COMPLEX WITH TUBULIN | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-methyl-3-[(4-methylphenyl)sulfonylamino]-~{N}-[(6-methylpyridin-3-yl)methyl]benzamide, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Du, T, Ji, M, Hou, Z, Lin, S, Zhang, J, Wu, D, Zhang, K, Lu, D, Xu, H, Chen, X. | Deposit date: | 2022-07-14 | Release date: | 2023-07-26 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Optimization of Benzamide Derivatives as Potent and Orally Active Tubulin Inhibitors Targeting the Colchicine Binding Site. J.Med.Chem., 65, 2022
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7EZ0
| Apo L-21 ScaI Tetrahymena ribozyme | Descriptor: | Apo L-21 ScaI Tetrahymena ribozyme, MAGNESIUM ION | Authors: | Su, Z, Zhang, K, Kappel, K, Luo, B, Das, R, Chiu, W. | Deposit date: | 2021-06-01 | Release date: | 2021-08-25 | Last modified: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (3.14 Å) | Cite: | Cryo-EM structures of full-length Tetrahymena ribozyme at 3.1 angstrom resolution. Nature, 596, 2021
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7EZ2
| Holo L-16 ScaI Tetrahymena ribozyme | Descriptor: | Holo L-16 ScaI Tetrahymena ribozyme, Holo L-16 ScaI Tetrahymena ribozyme S1, Holo L-16 ScaI Tetrahymena ribozyme S2, ... | Authors: | Su, Z, Zhang, K, Kappel, K, Luo, B, Das, R, Chiu, W. | Deposit date: | 2021-06-01 | Release date: | 2021-08-25 | Last modified: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (3.05 Å) | Cite: | Cryo-EM structures of full-length Tetrahymena ribozyme at 3.1 angstrom resolution. Nature, 596, 2021
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7FIZ
| Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex (conformation 3) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Lon protease, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | Authors: | Li, S, Hsieh, K, Kuo, C, Su, S, Huang, K, Zhang, K, Chang, C.I. | Deposit date: | 2021-08-01 | Release date: | 2021-11-24 | Method: | ELECTRON MICROSCOPY (3.28 Å) | Cite: | Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex. Sci Adv, 7, 2021
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7FID
| Processive cleavage of substrate at individual proteolytic active sites of the Lon proteasecomplex (conformation 1) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Lon protease, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | Authors: | Li, S, Hsieh, K, Kuo, C, Su, S, Huang, K, Zhang, K, Chang, C.I. | Deposit date: | 2021-07-31 | Release date: | 2021-11-24 | Method: | ELECTRON MICROSCOPY (2.44 Å) | Cite: | Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex. Sci Adv, 7, 2021
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7FIE
| Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex (conformation 2) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Lon protease, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | Authors: | Li, S, Hsieh, K, Kuo, C, Su, S, Huang, K, Zhang, K, Chang, C.I. | Deposit date: | 2021-07-31 | Release date: | 2021-11-24 | Method: | ELECTRON MICROSCOPY (2.36 Å) | Cite: | Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex. Sci Adv, 7, 2021
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3T9K
| Crystal Structure of ACAP1 C-portion mutant S554D fused with integrin beta1 peptide | Descriptor: | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1,Peptide from Integrin beta-1, SULFATE ION, ... | Authors: | Sun, F, Pang, X, Zhang, K, Ma, J, Zhou, Q. | Deposit date: | 2011-08-03 | Release date: | 2012-07-18 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Mechanistic insights into regulated cargo binding by ACAP1 protein J.Biol.Chem., 287, 2012
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