8EWG
 
 | | Cryo-EM structure of a riboendonclease | | Descriptor: | CRISPR-associated endonuclease Cas9, RNA (56-MER) | | Authors: | Li, Z, Wang, F. | | Deposit date: | 2022-10-23 | | Release date: | 2023-08-30 | | Last modified: | 2024-05-01 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structural Basis for the Ribonuclease Activity of a Thermostable CRISPR-Cas13a from Thermoclostridium caenicola.
J.Mol.Biol., 435, 2023
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7Y50
 | | Class I diterpene synthase (CyS) from Streptomyces cattleya | | Descriptor: | Putative glutamate dehydrogenase/leucine dehydrogenase | | Authors: | Xing, B, Ma, M. | | Deposit date: | 2022-06-16 | | Release date: | 2022-12-21 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal Structure Based Mutagenesis of Cattleyene Synthase Leads to the Generation of Rearranged Polycyclic Diterpenes.
Angew.Chem.Int.Ed.Engl., 61, 2022
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7Y87
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7Y88
 | | class I diterpene synthase (CyS-GGPP-Mg2+) from Streptomyces cattleya | | Descriptor: | GERANYLGERANYL DIPHOSPHATE, MAGNESIUM ION, Putative glutamate dehydrogenase/leucine dehydrogenase | | Authors: | Xing, B, Ma, M. | | Deposit date: | 2022-06-23 | | Release date: | 2022-12-21 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.87 Å) | | Cite: | Crystal Structure Based Mutagenesis of Cattleyene Synthase Leads to the Generation of Rearranged Polycyclic Diterpenes.
Angew.Chem.Int.Ed.Engl., 61, 2022
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4M6T
 | | Structure of human Paf1 and Leo1 complex | | Descriptor: | RNA polymerase II-associated factor 1 homolog, Linker, RNA polymerase-associated protein LEO1, ... | | Authors: | Shen, Y, Qin, X. | | Deposit date: | 2013-08-11 | | Release date: | 2013-10-02 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.498 Å) | | Cite: | Structural insights into Paf1 complex assembly and histone binding
Nucleic Acids Res., 41, 2013
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5ZYQ
 | | The Structure of Human PAF1/CTR9 complex | | Descriptor: | RNA polymerase-associated protein CTR9 homolog,RNA polymerase II-associated factor 1 homolog | | Authors: | Xie, Y, Zheng, M, Zhou, H, Long, J. | | Deposit date: | 2018-05-28 | | Release date: | 2018-09-26 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.531 Å) | | Cite: | Paf1 and Ctr9 subcomplex formation is essential for Paf1 complex assembly and functional regulation.
Nat Commun, 9, 2018
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5ZYP
 | | Structure of the Yeast Ctr9/Paf1 complex | | Descriptor: | NICKEL (II) ION, RNA polymerase-associated protein CTR9,RNA polymerase II-associated protein 1 | | Authors: | Xie, Y, Zheng, M, Zhou, H, Long, J. | | Deposit date: | 2018-05-28 | | Release date: | 2018-09-26 | | Last modified: | 2019-05-22 | | Method: | X-RAY DIFFRACTION (2.532 Å) | | Cite: | Paf1 and Ctr9 subcomplex formation is essential for Paf1 complex assembly and functional regulation.
Nat Commun, 9, 2018
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7S4E
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4DUM
 | | Co-crystal structure of eIF4E with inhibitor | | Descriptor: | (4-{7-[2-(4-chlorophenoxy)ethyl]-2-(methylamino)-6-oxo-6,7-dihydro-1H-purin-8-yl}phenyl)phosphonic acid, 1,2-ETHANEDIOL, Eukaryotic translation initiation factor 4E | | Authors: | Min, X, Johnstone, S, Walker, N, Wang, Z. | | Deposit date: | 2012-02-22 | | Release date: | 2012-04-11 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.95 Å) | | Cite: | Structure-Guided Design, Synthesis, and Evaluation of Guanine-Derived Inhibitors of the eIF4E mRNA-Cap Interaction.
J.Med.Chem., 55, 2012
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4DT6
 | | Co-crystal structure of eIF4E with inhibitor | | Descriptor: | 1,2-ETHANEDIOL, 7-[2-(4-chlorophenoxy)ethyl]guanosine 5'-(dihydrogen phosphate), Eukaryotic translation initiation factor 4E, ... | | Authors: | Min, X, Johnstone, S, Walker, N, Wang, Z. | | Deposit date: | 2012-02-20 | | Release date: | 2012-04-11 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structure-Guided Design, Synthesis, and Evaluation of Guanine-Derived Inhibitors of the eIF4E mRNA-Cap Interaction.
J.Med.Chem., 55, 2012
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3GXA
 | | Crystal structure of GNA1946 | | Descriptor: | METHIONINE, Outer membrane lipoprotein GNA1946, SULFATE ION | | Authors: | Yang, X, Shen, Y. | | Deposit date: | 2009-04-02 | | Release date: | 2009-10-13 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Crystal structure of lipoprotein GNA1946 from Neisseria meningitidis
J.Struct.Biol., 168, 2009
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7CMW
 | | Complex structure of PARP1 catalytic domain with pamiparib | | Descriptor: | (2R)-14-fluoro-2-methyl-6,9,10,19-tetrazapentacyclo[14.2.1.02,6.08,18.012,17]nonadeca-1(18),8,12(17),13,15-pentaen-11-one, GLYCEROL, Poly [ADP-ribose] polymerase 1 | | Authors: | Feng, Y.C, Peng, H, Hong, Y, Liu, Y. | | Deposit date: | 2020-07-29 | | Release date: | 2020-12-16 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Discovery of Pamiparib (BGB-290), a Potent and Selective Poly (ADP-ribose) Polymerase (PARP) Inhibitor in Clinical Development.
J.Med.Chem., 63, 2020
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2ZMV
 | | Crystal structure of Synbindin | | Descriptor: | Trafficking protein particle complex subunit 4 | | Authors: | Fan, F. | | Deposit date: | 2008-04-21 | | Release date: | 2008-07-01 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Crystal structure of human synbindin reveals two conformations of longin domain
Biochem.Biophys.Res.Commun., 378, 2009
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3IR1
 | | Crystal Structure of Lipoprotein GNA1946 from Neisseria meningitidis | | Descriptor: | METHIONINE, Outer membrane lipoprotein GNA1946, SULFATE ION | | Authors: | Yang, X, Wu, Z, Wang, X, Shen, Y. | | Deposit date: | 2009-08-21 | | Release date: | 2009-10-13 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Crystal structure of lipoprotein GNA1946 from Neisseria meningitidis
J.Struct.Biol., 168, 2009
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3K3P
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3OV8
 | | Crystal structure of AF1382 from Archaeoglobus fulgidus, High resolution | | Descriptor: | ACETATE ION, CHLORIDE ION, Protein AF_1382 | | Authors: | Zhu, J.-Y, Zhao, M, Fu, Z.-Q, Yang, H, Chang, J, Hao, X, Chen, L, Rose, J.P, Wang, B.C, Southeast Collaboratory for Structural Genomics (SECSG) | | Deposit date: | 2010-09-16 | | Release date: | 2011-11-16 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.8501 Å) | | Cite: | Structure of the Archaeoglobus fulgidus orphan ORF AF1382 determined by sulfur SAD from a moderately diffracting crystal.
Acta Crystallogr.,Sect.D, 68, 2012
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7XLQ
 | | Structure of human R-type voltage-gated CaV2.3-alpha2/delta1-beta1 channel complex in the ligand-free (apo) state | | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Gao, Y, Qiu, Y, Wei, Y, Dong, Y, Zhang, X.C, Zhao, Y. | | Deposit date: | 2022-04-22 | | Release date: | 2023-02-08 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Molecular insights into the gating mechanisms of voltage-gated calcium channel Ca V 2.3.
Nat Commun, 14, 2023
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3CGW
 | | Crystal structure of 2-phospho-(S)-lactate transferase from Methanosarcina mazei. Northeast Structural Genomics Consortium target MaR46 | | Descriptor: | LPPG:FO 2-phospho-L-lactate transferase | | Authors: | Forouhar, F, Abashidze, M, Seetharaman, J, Vorobiev, S.M, Ciao, M, Janjua, H, Xiao, R, Acton, T.B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2008-03-06 | | Release date: | 2008-03-18 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Molecular insights into the biosynthesis of the f420 coenzyme.
J.Biol.Chem., 283, 2008
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7W7F
 | | Cryo-EM structure of human NaV1.3/beta1/beta2-ICA121431 | | Descriptor: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 2,2-diphenyl-~{N}-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]ethanamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Jiang, D, Li, X. | | Deposit date: | 2021-12-04 | | Release date: | 2022-04-06 | | Method: | ELECTRON MICROSCOPY (3.35 Å) | | Cite: | Structural basis for modulation of human Na V 1.3 by clinical drug and selective antagonist.
Nat Commun, 13, 2022
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7W77
 | | cryo-EM structure of human NaV1.3/beta1/beta2-bulleyaconitineA | | Descriptor: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Jiang, D, Li, X. | | Deposit date: | 2021-12-03 | | Release date: | 2022-04-06 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structural basis for modulation of human Na V 1.3 by clinical drug and selective antagonist.
Nat Commun, 13, 2022
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5F54
 | | Structure of RecJ complexed with dTMP | | Descriptor: | MANGANESE (II) ION, Single-stranded-DNA-specific exonuclease, THYMIDINE-5'-PHOSPHATE | | Authors: | Hua, Y, Zhao, Y, Cheng, K. | | Deposit date: | 2015-12-04 | | Release date: | 2016-06-15 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structural basis for DNA 5 -end resection by RecJ
Elife, 5, 2016
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5F56
 | | Structure of RecJ complexed with DNA and SSB-ct | | Descriptor: | ALA-ASP-LEU-PRO-PHE, DNA (5'-D(*CP*TP*GP*AP*TP*GP*GP*CP*A)-3'), MANGANESE (II) ION, ... | | Authors: | Zhao, Y, Hua, Y, Cheng, K. | | Deposit date: | 2015-12-04 | | Release date: | 2016-06-15 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural basis for DNA 5 -end resection by RecJ
Elife, 5, 2016
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5F55
 | | Structure of RecJ complexed with DNA | | Descriptor: | DNA (5'-D(*GP*AP*TP*GP*TP*AP*CP*GP*CP*TP*AP*GP*GP*C)-3'), MANGANESE (II) ION, SULFATE ION, ... | | Authors: | Hua, Y, Zhao, Y, Cheng, K. | | Deposit date: | 2015-12-04 | | Release date: | 2016-06-15 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural basis for DNA 5 -end resection by RecJ
Elife, 5, 2016
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1OVL
 | | Crystal Structure of Nurr1 LBD | | Descriptor: | BROMIDE ION, IODIDE ION, Orphan nuclear receptor NURR1 (MSE 414, ... | | Authors: | Wang, Z, Liu, J, Walker, N. | | Deposit date: | 2003-03-26 | | Release date: | 2003-06-03 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structure and Function of Nurr1 identifies a Class of Ligand-Independent Nuclear Receptors
Nature, 423, 2003
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7DUQ
 | | Cryo-EM structure of the compound 2 and GLP-1-bound human GLP-1 receptor-Gs complex | | Descriptor: | CHOLESTEROL, Glucagon-like peptide 1, Glucagon-like peptide 1 receptor, ... | | Authors: | Cong, Z, Chen, L, Ma, H, Zhou, Q, Zou, X, Ye, C, Dai, A, Liu, Q, Huang, W, Sun, X, Wang, X, Xu, P, Zhao, L, Xia, T, Zhong, W, Yang, D, Xu, H.E, Zhang, Y, Wang, M. | | Deposit date: | 2021-01-11 | | Release date: | 2021-07-14 | | Method: | ELECTRON MICROSCOPY (2.5 Å) | | Cite: | Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor.
Nat Commun, 12, 2021
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