2I3H
 
 | | Structure of an ML-IAP/XIAP chimera bound to a 4-mer peptide (AVPW) | | Descriptor: | 1,2-ETHANEDIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, AVPW peptide, ... | | Authors: | Fairbrother, W.J, Franklin, M.C. | | Deposit date: | 2006-08-18 | | Release date: | 2006-09-19 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.62 Å) | | Cite: | Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs.
Acs Chem.Biol., 1, 2006
|
|
2I3I
 | | Structure of an ML-IAP/XIAP chimera bound to a peptidomimetic | | Descriptor: | (3R,6R,9AR)-2,2-DIMETHYL-6-[(N-METHYL-L-ALANYL)AMINO]-N-(3-METHYL-1-PHENYL-1H-PYRAZOL-5-YL)-5-OXO-2,3,5,6,9,9A-HEXAHYDRO[1,3]THIAZOLO[3,2-A]AZEPINE-3-CARBOXAMIDE, 1,2-ETHANEDIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | | Authors: | Fairbrother, W.J, Franklin, M.C. | | Deposit date: | 2006-08-18 | | Release date: | 2006-09-19 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs.
Acs Chem.Biol., 1, 2006
|
|
6HNK
 | | The ligand-free, open structure of CD0873, a substrate binding protein with adhesive properties from Clostridium difficile. | | Descriptor: | ABC-type transport system, sugar-family extracellular solute-binding protein | | Authors: | Bradshaw, W.J, Kovacs-Simon, A, Harmer, N.J, Michell, S.L, Acharya, K.R. | | Deposit date: | 2018-09-15 | | Release date: | 2019-08-28 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Molecular features of lipoprotein CD0873: A potential vaccine against the human pathogenClostridioides difficile.
J.Biol.Chem., 294, 2019
|
|
8U5Y
 | | human RADX trimer bound to ssDNA | | Descriptor: | DNA (25-MER), RPA-related protein RADX | | Authors: | Balakrishnan, S, Chazin, W.J. | | Deposit date: | 2023-09-13 | | Release date: | 2023-10-11 | | Last modified: | 2023-10-18 | | Method: | ELECTRON MICROSCOPY (3.01 Å) | | Cite: | Structure of RADX and mechanism for regulation of RAD51 nucleofilaments.
Biorxiv, 2023
|
|
8TNE
 | | Crystal structure of bacterial pectin methylesterase Pme8A from rumen Butyrivibrio | | Descriptor: | 1,2-ETHANEDIOL, Pectinesterase | | Authors: | Carbone, V, Reilly, K, Sang, C, Schofield, L, Ronimus, R, Kelly, W.J, Attwood, G.T, Palevich, N. | | Deposit date: | 2023-08-01 | | Release date: | 2023-08-16 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal Structures of Bacterial Pectin Methylesterases Pme8A and PmeC2 from Rumen Butyrivibrio .
Int J Mol Sci, 24, 2023
|
|
8TMS
 | | Crystal structure of bacterial pectin methylesterase PmeC2 from rumen Butyrivibrio | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Pectinesterase | | Authors: | Carbone, V, Reilly, K, Sang, C, Schofield, L, Ronimus, R, Kelly, W.J, Attwood, G.T, Palevich, N. | | Deposit date: | 2023-07-30 | | Release date: | 2023-08-16 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal Structures of Bacterial Pectin Methylesterases Pme8A and PmeC2 from Rumen Butyrivibrio .
Int J Mol Sci, 24, 2023
|
|
2VGH
 | | HEPARIN-BINDING DOMAIN FROM VASCULAR ENDOTHELIAL GROWTH FACTOR, NMR, MINIMIZED AVERAGE STRUCTURE | | Descriptor: | VASCULAR ENDOTHELIAL GROWTH FACTOR-165 | | Authors: | Fairbrother, W.J, Champe, M.A, Christinger, H.W, Keyt, B.A, Starovasnik, M.A. | | Deposit date: | 1997-12-17 | | Release date: | 1998-04-08 | | Last modified: | 2022-03-16 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the heparin-binding domain of vascular endothelial growth factor.
Structure, 6, 1998
|
|
8U61
 | | Human RADX tetramer bound to ssDNA | | Descriptor: | RPA-related protein RADX, dT25 DNA (25-MER) | | Authors: | Balakrishnan, S, Chazin, W.J. | | Deposit date: | 2023-09-13 | | Release date: | 2024-01-31 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Structure of RADX and mechanism for regulation of RAD51 nucleofilaments.
Proc.Natl.Acad.Sci.USA, 121, 2024
|
|
2UYZ
 | | Non-covalent complex between Ubc9 and SUMO1 | | Descriptor: | SMALL UBIQUITIN-RELATED MODIFIER 1, SODIUM ION, SUMO-CONJUGATING ENZYME UBC9 | | Authors: | Knipscheer, P, van Dijk, W.J, Olsen, J.V, Mann, M, Sixma, T.K. | | Deposit date: | 2007-04-21 | | Release date: | 2007-06-12 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Noncovalent interaction between Ubc9 and SUMO promotes SUMO chain formation.
EMBO J., 26, 2007
|
|
2W9P
 | | Crystal Structure of Potato Multicystatin | | Descriptor: | MULTICYSTATIN | | Authors: | Nissen, M.S, Kumar, G.N, Youn, B, Knowles, D.B, Lam, K.S, Ballinger, W.J, Knowles, N.R, Kang, C. | | Deposit date: | 2009-01-28 | | Release date: | 2010-02-02 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Characterization of Solanum Tuberosum Multicystatin and its Structural Comparison with Other Cystatins.
Plant Cell, 21, 2009
|
|
2VOY
 | | CryoEM model of CopA, the copper transporting ATPase from Archaeoglobus fulgidus | | Descriptor: | CATION-TRANSPORTING ATPASE, P-TYPE, POTENTIAL COPPER-TRANSPORTING ATPASE, ... | | Authors: | Wu, C.-C, Rice, W.J, Stokes, D.L. | | Deposit date: | 2008-02-25 | | Release date: | 2009-05-26 | | Last modified: | 2022-05-04 | | Method: | ELECTRON MICROSCOPY (18 Å) | | Cite: | Structure of a Copper Pump Suggests a Regulatory Role for its Metal-Binding Domain.
Structure, 16, 2008
|
|
2W9Q
 | | Crystal Structure of Potato Multicystatin-P212121 | | Descriptor: | MULTICYSTATIN | | Authors: | Nissen, M.S, Kumar, G.N, Youn, B, Knowles, D.B, Lam, K.S, Ballinger, W.J, Knowles, N.R, Kang, C. | | Deposit date: | 2009-01-28 | | Release date: | 2010-02-02 | | Last modified: | 2019-09-04 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Characterization of Solanum Tuberosum Multicystatin and its Structural Comparison with Other Cystatins.
Plant Cell, 21, 2009
|
|
2W8I
 | | Crystal structure of Wza24-345. | | Descriptor: | PUTATIVE OUTER MEMBRANE LIPOPROTEIN WZA | | Authors: | Hagelueken, G, Ingledew, W.J, Huang, H, Petrovic-Stojanovska, B, Whitfield, C, ElMkami, H, Schiemann, O, Naismith, J.H. | | Deposit date: | 2009-01-16 | | Release date: | 2009-02-10 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Peldor Distance Fingerprinting of the Octameric Outer-Membrane Protein Wza from Escherichia Coli.
Angew.Chem.Int.Ed.Engl., 48, 2009
|
|
2VRR
 | | Structure of SUMO modified Ubc9 | | Descriptor: | FORMIC ACID, SMALL UBIQUITIN-RELATED MODIFIER 1, SODIUM ION, ... | | Authors: | Knipscheer, P, Flotho, A, Klug, H, Olsen, J.V, van Dijk, W.J, Fish, A, Johnson, E.S, Mann, M, Sixma, T.K, Pichler, A. | | Deposit date: | 2008-04-13 | | Release date: | 2008-08-19 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.22 Å) | | Cite: | Ubc9 sumoylation regulates SUMO target discrimination.
Mol. Cell, 31, 2008
|
|
8G9L
 | | DNA initiation subcomplex of Xenopus laevis DNA polymerase alpha-primase | | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA polymerase alpha catalytic subunit, DNA primase large subunit, ... | | Authors: | Mullins, E.A, Durie, C.L, Ohi, M.D, Chazin, W.J, Eichman, B.F. | | Deposit date: | 2023-02-21 | | Release date: | 2023-04-12 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | A mechanistic model of primer synthesis from catalytic structures of DNA polymerase alpha-primase.
Nat.Struct.Mol.Biol., 2024
|
|
8G9N
 | | Partial DNA elongation subcomplex of Xenopus laevis DNA polymerase alpha-primase | | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA polymerase alpha catalytic subunit, DNA template, ... | | Authors: | Mullins, E.A, Durie, C.L, Ohi, M.D, Chazin, W.J, Eichman, B.F. | | Deposit date: | 2023-02-21 | | Release date: | 2023-04-12 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | A mechanistic model of primer synthesis from catalytic structures of DNA polymerase alpha-primase.
Nat.Struct.Mol.Biol., 2024
|
|
8G99
 | |
8G9F
 | |
8G9O
 | | Complete DNA elongation subcomplex of Xenopus laevis DNA polymerase alpha-primase | | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA polymerase alpha catalytic subunit, DNA primase large subunit, ... | | Authors: | Mullins, E.A, Durie, C.L, Ohi, M.D, Chazin, W.J, Eichman, B.F. | | Deposit date: | 2023-02-21 | | Release date: | 2023-04-12 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | A mechanistic model of primer synthesis from catalytic structures of DNA polymerase alpha-primase.
Nat.Struct.Mol.Biol., 2024
|
|
2WC0
 | | crystal structure of human insulin degrading enzyme in complex with iodinated insulin | | Descriptor: | 1,4-DIETHYLENE DIOXIDE, INSULIN A CHAIN, INSULIN B CHAIN, ... | | Authors: | Manolopoulou, M, Guo, Q, Malito, E, Schilling, A.B, Tang, W.J. | | Deposit date: | 2009-03-06 | | Release date: | 2009-03-24 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Molecular Basis of Catalytic Chamber-Assisted Unfolding and Cleavage of Human Insulin by Human Insulin Degrading Enzyme.
J.Biol.Chem., 284, 2009
|
|
2W8H
 | | Crystal structure of spin labeled Wza24-345. | | Descriptor: | CHLORIDE ION, PUTATIVE OUTER MEMBRANE LIPOPROTEIN WZA, S-[(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl] methanesulfonothioate | | Authors: | Hagelueken, G, Ingledew, W.J, Huang, H, Petrovic-Stojanovska, B, Whitfield, C, ElMkami, H, Schiemann, O, Naismith, J.H. | | Deposit date: | 2009-01-16 | | Release date: | 2009-02-10 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.76 Å) | | Cite: | Peldor Distance Fingerprinting of the Octameric Outer-Membrane Protein Wza from Escherichia Coli.
Angew.Chem.Int.Ed.Engl., 48, 2009
|
|
2WBY
 | | Crystal structure of human insulin-degrading enzyme in complex with insulin | | Descriptor: | INSULIN A CHAIN, INSULIN B CHAIN, INSULIN-DEGRADING ENZYME, ... | | Authors: | Manolopoulou, M, Guo, Q, Malito, E, Schilling, A.B, Tang, W.J. | | Deposit date: | 2009-03-06 | | Release date: | 2009-03-24 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Molecular Basis of Catalytic Chamber-Assisted Unfolding and Cleavage of Human Insulin by Human Insulin Degrading Enzyme.
J.Biol.Chem., 284, 2009
|
|
2WYC
 | | The quorum quenching N-acyl homoserine lactone acylase PvdQ in complex with 3-oxo-lauric acid | | Descriptor: | 3-OXODODECANOIC ACID, ACYL-HOMOSERINE LACTONE ACYLASE PVDQ SUBUNIT ALPHA, ACYL-HOMOSERINE LACTONE ACYLASE PVDQ SUBUNIT BETA, ... | | Authors: | Bokhove, M, Nadal Jimenez, P, Quax, W.J, Dijkstra, B.W. | | Deposit date: | 2009-11-16 | | Release date: | 2009-12-29 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | The Quorum-Quenching N-Acyl Homoserine Lactone Acylase Pvdq is an Ntn-Hydrolase with an Unusual Substrate-Binding Pocket
Proc.Natl.Acad.Sci.USA, 107, 2010
|
|
2X2T
 | | CRYSTAL STRUCTURE OF SCLEROTINIA SCLEROTIORUM AGGLUTININ SSA in complex with Gal-beta1,3-Galnac | | Descriptor: | AGGLUTININ, SULFATE ION, TETRAETHYLENE GLYCOL, ... | | Authors: | Sulzenbacher, G, Roig-Zamboni, V, Peumans, W.J, Rouge, P, Van Damme, E.J.M, Bourne, Y. | | Deposit date: | 2010-01-15 | | Release date: | 2010-05-26 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.97 Å) | | Cite: | Crystal Structure of the Galnac/Gal-Specific Agglutinin from the Phytopathogenic Ascomycete Sclerotinia Sclerotiorum Reveals Novel Adaptation of a Beta-Trefoil Domain
J.Mol.Biol., 400, 2010
|
|
2WK3
 | |
