1EVW
 
 | | L116A MUTANT OF THE HOMING ENDONUCLEASE I-PPOI COMPLEXED TO HOMING SITE DNA. | | 分子名称: | DNA (5'-D(*TP*GP*AP*CP*TP*CP*TP*CP*TP*TP*AP*A)-3'), DNA (5'-D(*TP*GP*GP*CP*TP*AP*CP*CP*TP*TP*AP*A)-3'), DNA (5'-D(P*GP*AP*GP*AP*GP*TP*CP*A)-3'), ... | | 著者 | Galburt, E.A, Jurica, M.S, Chevalier, B.S, Erho, D, Stoddard, B.L. | | 登録日 | 2000-04-20 | | 公開日 | 2000-08-03 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Conformational changes and cleavage by the homing endonuclease I-PpoI: a critical role for a leucine residue in the active site.
J.Mol.Biol., 300, 2000
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1G9Z
 | | LAGLIDADG HOMING ENDONUCLEASE I-CREI / DNA PRODUCT COMPLEX WITH MAGNESIUM | | 分子名称: | 5'-D(*CP*GP*AP*AP*AP*CP*TP*GP*TP*CP*TP*CP*AP*C)-3', 5'-D(*GP*CP*AP*AP*AP*AP*CP*GP*TP*CP*GP*TP*GP*A)-3', 5'-D(P*GP*AP*CP*AP*GP*TP*TP*TP*CP*G)-3', ... | | 著者 | Chevalier, B, Monnat, R.J, Stoddard, B.L. | | 登録日 | 2000-11-28 | | 公開日 | 2001-04-02 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | The homing endonuclease I-CreI uses three metals, one of which is shared between the two active sites.
Nat.Struct.Biol., 8, 2001
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7SQ4
 | | Designed trefoil knot protein, variant 2 | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, Designed trefoil knot protein, variant 2, ... | | 著者 | Takushi, B, Doyle, L, Stoddard, B.L, Bradley, P. | | 登録日 | 2021-11-04 | | 公開日 | 2022-06-29 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.493 Å) | | 主引用文献 | De novo design of knotted tandem repeat proteins.
Nat Commun, 14, 2023
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7SQ3
 | | Designed trefoil knot protein, variant 1 | | 分子名称: | CHLORIDE ION, Designed trefoil knot protein, variant 1, ... | | 著者 | Takushi, B, Doyle, L, Stoddard, B.L, Bradley, P. | | 登録日 | 2021-11-04 | | 公開日 | 2022-06-29 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.453 Å) | | 主引用文献 | De novo design of knotted tandem repeat proteins.
Nat Commun, 14, 2023
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7SQ5
 | | Designed trefoil knot protein, variant 3 | | 分子名称: | Designed trefoil knot protein, variant 3, SODIUM ION | | 著者 | Takushi, B, Doyle, L, Stoddard, B.L, Bradley, P. | | 登録日 | 2021-11-04 | | 公開日 | 2022-11-09 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.205 Å) | | 主引用文献 | De novo design of knotted tandem repeat proteins.
Nat Commun, 14, 2023
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3LDY
 | | An extraordinary mechanism of DNA perturbation exhibited by the rare-cutting HNH restriction endonuclease PacI | | 分子名称: | CALCIUM ION, DNA (5'-D(*GP*AP*GP*GP*CP*TP*TP*A)-3'), DNA (5'-D(P*AP*TP*TP*AP*AP*GP*CP*CP*TP*C)-3'), ... | | 著者 | Shen, B.W, Heiter, D, Chan, S.-H, Xu, S.-Y, Wilson, G, Stoddard, B.L. | | 登録日 | 2010-01-13 | | 公開日 | 2010-04-21 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | | 主引用文献 | Unusual target site disruption by the rare-cutting HNH restriction endonuclease PacI.
Structure, 18, 2010
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3MIS
 | | I-MsoI re-designed for altered DNA cleavage specificity (-8G) | | 分子名称: | CALCIUM ION, DNA (5'-D(*CP*GP*GP*AP*GP*CP*TP*GP*TP*CP*TP*CP*AP*CP*GP*AP*CP*GP*TP*CP*CP*TP*GP*C)-3'), DNA (5'-D(*GP*CP*AP*GP*GP*AP*CP*GP*TP*CP*GP*TP*GP*AP*GP*AP*CP*AP*GP*CP*TP*CP*CP*G)-3'), ... | | 著者 | Taylor, G.K, Stoddard, B.L. | | 登録日 | 2010-04-12 | | 公開日 | 2010-05-19 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Computational reprogramming of homing endonuclease specificity at multiple adjacent base pairs.
Nucleic Acids Res., 38, 2010
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3MIP
 | | I-MsoI re-designed for altered DNA cleavage specificity (-8GCG) | | 分子名称: | CALCIUM ION, DNA (5'-D(*CP*GP*GP*AP*GP*CP*GP*GP*TP*CP*TP*CP*AP*CP*GP*AP*CP*CP*GP*CP*CP*TP*GP*C)-3'), DNA (5'-D(*GP*CP*AP*GP*GP*CP*GP*GP*TP*CP*GP*TP*GP*AP*GP*AP*CP*CP*GP*CP*TP*CP*CP*G)-3'), ... | | 著者 | Taylor, G.K, Stoddard, B.L. | | 登録日 | 2010-04-11 | | 公開日 | 2010-05-19 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Computational reprogramming of homing endonuclease specificity at multiple adjacent base pairs.
Nucleic Acids Res., 38, 2010
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3MX1
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3MX4
 | | DNA binding and cleavage by the GIY-YIG endonuclease R.Eco29KI inactive variant E142Q | | 分子名称: | DNA (5'-D(P*CP*GP*GP*GP*AP*GP*GP*CP*CP*CP*GP*CP*GP*GP*GP*CP*CP*GP*CP*CP*GP*C)-3'), DNA (5'-D(P*GP*CP*GP*GP*CP*GP*GP*CP*CP*CP*GP*CP*GP*GP*GP*CP*CP*TP*CP*CP*CP*G)-3'), Eco29kIR | | 著者 | Mak, A.N.S, Lambert, A.R, Stoddard, B.L. | | 登録日 | 2010-05-06 | | 公開日 | 2010-09-08 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Folding, DNA Recognition, and Function of GIY-YIG Endonucleases: Crystal Structures of R.Eco29kI.
Structure, 18, 2010
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3KO2
 | | I-MsoI re-designed for altered DNA cleavage specificity (-7C) | | 分子名称: | 5'-D(*CP*GP*GP*AP*AP*CP*TP*GP*TP*CP*TP*CP*AP*CP*GP*AP*CP*GP*GP*TP*CP*TP*GP*C)-3', 5'-D(*GP*CP*AP*GP*AP*CP*CP*GP*TP*CP*GP*TP*GP*AP*GP*AP*CP*AP*GP*TP*TP*CP*CP*G)-3', CALCIUM ION, ... | | 著者 | Taylor, G.K, Stoddard, B.L. | | 登録日 | 2009-11-13 | | 公開日 | 2010-05-19 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Computational reprogramming of homing endonuclease specificity at multiple adjacent base pairs.
Nucleic Acids Res., 38, 2010
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3NIC
 | | DNA binding and cleavage by the GIY-YIG endonuclease R.Eco29kI inactive variant Y49F | | 分子名称: | DNA (5'-D(P*CP*GP*GP*GP*AP*GP*GP*CP*CP*CP*GP*CP*GP*GP*GP*CP*CP*GP*CP*CP*GP*C)-3'), DNA (5'-D(P*GP*CP*GP*GP*CP*GP*GP*CP*CP*CP*GP*CP*GP*GP*GP*CP*CP*TP*CP*CP*CP*G)-3'), Eco29kIR, ... | | 著者 | Mak, A.N.S, Lambert, A.R, Stoddard, B.L. | | 登録日 | 2010-06-15 | | 公開日 | 2010-09-08 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Folding, DNA Recognition, and Function of GIY-YIG Endonucleases: Crystal Structures of R.Eco29kI.
Structure, 18, 2010
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3M7K
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7RDR
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7RCF
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7RCG
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7RCD
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7RCE
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7RCC
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7R9G
 | | Catalytically inactive yeast Pseudouridine Synthase, PUS1, bound to RNA | | 分子名称: | CHLORIDE ION, RNA (5'-R(*AP*AP*AP*UP*CP*GP*GP*GP*AP*UP*UP*CP*CP*GP*GP*AP*UP*A)-3'), SULFATE ION, ... | | 著者 | Doyle, L.A, Stoddard, B.L. | | 登録日 | 2021-06-29 | | 公開日 | 2021-12-15 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | The structural basis of mRNA recognition and binding by yeast pseudouridine synthase PUS1.
Plos One, 18, 2023
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7R9F
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1QYS
 | | Crystal structure of Top7: A computationally designed protein with a novel fold | | 分子名称: | TOP7 | | 著者 | Kuhlman, B, Dantas, G, Ireton, G.C, Varani, G, Stoddard, B.L, Baker, D. | | 登録日 | 2003-09-11 | | 公開日 | 2003-11-25 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Design of a Novel Globular Protein Fold with Atomic-Level Accuracy
Science, 302, 2003
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1R9Y
 | | Bacterial cytosine deaminase D314A mutant. | | 分子名称: | Cytosine deaminase, FE (III) ION, GLYCEROL, ... | | 著者 | Mahan, S.D, Ireton, G.C, Stoddard, B.L, Black, M.E. | | 登録日 | 2003-10-31 | | 公開日 | 2004-10-05 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | | 主引用文献 | Random mutagenesis and selection of Escherichia coli cytosine deaminase for cancer gene therapy.
Protein Eng.Des.Sel., 17, 2004
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1RB7
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1RC8
 | | T4 Polynucleotide Kinase bound to 5'-GTCAC-3' ssDNA | | 分子名称: | 5'-D(*GP*TP*CP*AP*C)-3', ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, ... | | 著者 | Eastberg, J.H, Pelletier, J, Stoddard, B.L. | | 登録日 | 2003-11-03 | | 公開日 | 2004-02-17 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Recognition of DNA substrates by T4 bacteriophage polynucleotide kinase.
Nucleic Acids Res., 32, 2004
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