1UKV
 
 | | Structure of RabGDP-dissociation inhibitor in complex with prenylated YPT1 GTPase | | Descriptor: | GERAN-8-YL GERAN, GTP-binding protein YPT1, GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Rak, A, Pylypenko, O, Durek, T, Watzke, A, Kushnir, S, Brunsveld, L, Waldmann, H, Goody, R.S, Alexandrov, K. | | Deposit date: | 2003-09-01 | | Release date: | 2004-09-01 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Structure of Rab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPase
Science, 302, 2003
|
|
1N3G
 | |
1VG8
 | | GPPNHP-Bound Rab7 | | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related protein Rab-7 | | Authors: | Rak, A, Pylypenko, O, Niculae, A, Pyatkov, K, Goody, R.S, Alexandrov, K. | | Deposit date: | 2004-04-23 | | Release date: | 2004-07-20 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structure of the Rab7:REP-1 complex: insights into the mechanism of Rab prenylation and choroideremia disease
Cell(Cambridge,Mass.), 117, 2004
|
|
1VG1
 | | GDP-Bound Rab7 | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ras-related protein Rab-7 | | Authors: | Rak, A, Pylypenko, O, Niculae, A, Pyatkov, K, Goody, R.S, Alexandrov, K. | | Deposit date: | 2004-04-22 | | Release date: | 2004-07-20 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structure of the Rab7:REP-1 complex: insights into the mechanism of Rab prenylation and choroideremia disease
Cell(Cambridge,Mass.), 117, 2004
|
|
1VG0
 | | The crystal structures of the REP-1 protein in complex with monoprenylated Rab7 protein | | Descriptor: | CHLORIDE ION, GERAN-8-YL GERAN, GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Rak, A, Pylypenko, O, Niculae, A, Pyatkov, K, Goody, R.S, Alexandrov, K. | | Deposit date: | 2004-04-22 | | Release date: | 2004-07-20 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structure of the Rab7:REP-1 complex: insights into the mechanism of Rab prenylation and choroideremia disease
Cell(Cambridge,Mass.), 117, 2004
|
|
1VG9
 | | The crystal structures of the REP-1 protein in complex with C-terminally truncated Rab7 protein | | Descriptor: | 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Rak, A, Pylypenko, O, Niculae, A, Pyatkov, K, Goody, R.S, Alexandrov, K. | | Deposit date: | 2004-04-23 | | Release date: | 2004-07-20 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structure of the Rab7:REP-1 complex: insights into the mechanism of Rab prenylation and choroideremia disease
Cell(Cambridge,Mass.), 117, 2004
|
|
1FKM
 | | CRYSTAL STRUCTURE OF THE YPT/RAB-GAP DOMAIN OF GYP1P | | Descriptor: | PROTEIN (GYP1P) | | Authors: | Rak, A, Fedorov, R, Alexandrov, K, Albert, S, Goody, R.S, Gallwitz, D, Scheidig, A.J. | | Deposit date: | 2000-08-09 | | Release date: | 2001-02-09 | | Last modified: | 2022-12-21 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structure of the GAP domain of Gyp1p: first insights into interaction with Ypt/Rab proteins.
EMBO J., 19, 2000
|
|
8BW0
 | | Structure of CEACAM5 A3-B3 domain in Complex with Tusamitamab Fab | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Carcinoembryonic antigen-related cell adhesion molecule 5, ... | | Authors: | Kumar, A, Bertrand, T, Rapisarda, C, Rak, A. | | Deposit date: | 2022-12-06 | | Release date: | 2024-01-24 | | Method: | ELECTRON MICROSCOPY (3.11 Å) | | Cite: | Structural insights into epitope-paratope interactions of monoclonal antibody targeting CEACAM5-expressing tumors
Res Sq, 2023
|
|
4UUQ
 | | Crystal structure of human mono-glyceride lipase in complex with SAR127303 | | Descriptor: | 4-({[(4-chlorophenyl)sulfonyl]amino}methyl)piperidine-1-carboxylic acid, MONOGLYCERIDE LIPASE | | Authors: | Griebel, G, Pichat, P, Beeske, S, Leroy, T, Redon, N, Francon, D, Bert, L, Even, L, Lopez-Grancha, M, Tolstykh, T, Sun, F, Yu, Q, Brittain, S, Arlt, H, He, T, Zhang, B, Wiederschain, D, Bertrand, T, Houtman, J, Rak, A, Vallee, F, Michot, N, Auge, F, Menet, V, Bergis, O.E, George, P, Avenet, P, Mikol, V, Didier, M, Escoubet, J. | | Deposit date: | 2014-07-30 | | Release date: | 2015-01-21 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.36 Å) | | Cite: | Selective Blockade of the Hydrolysis of the Endocannabinoid 2-Arachidonoylglycerol Impairs Learning and Memory Performance While Producing Antinociceptive Activity in Rodents.
Sci.Rep., 5, 2015
|
|
6SBO
 | | Estrogen receptor mutant L536S | | Descriptor: | 6-(2,4-dichlorophenyl)-5-[4-[(3~{S})-1-(3-fluoranylpropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7~{H}-benzo[7]annulene-2-carboxylic acid, Estrogen receptor | | Authors: | Vallee, F, Steier, V, Rak, A. | | Deposit date: | 2019-07-22 | | Release date: | 2019-11-27 | | Last modified: | 2024-05-15 | | Method: | X-RAY DIFFRACTION (1.48 Å) | | Cite: | Discovery of 6-(2,4-Dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid (SAR439859), a Potent and Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen-Receptor-Positive Breast Cancer.
J.Med.Chem., 63, 2020
|
|
3DAD
 | | Crystal structure of the N-terminal regulatory domains of the formin FHOD1 | | Descriptor: | FH1/FH2 domain-containing protein 1 | | Authors: | Schulte, A, Stolp, B, Schonichen, A, Pylypenko, O, Rak, A, Fackler, O.T, Geyer, M. | | Deposit date: | 2008-05-29 | | Release date: | 2008-09-16 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | The Human Formin FHOD1 Contains a Bipartite Structure of FH3 and GTPase-Binding Domains Required for Activation.
Structure, 16, 2008
|
|
5BX0
 | |
1LTX
 | | Structure of Rab Escort Protein-1 in complex with Rab geranylgeranyl transferase and isoprenoid | | Descriptor: | AAAA, CHLORIDE ION, FARNESYL, ... | | Authors: | Pylypenko, O, Rak, A, Reents, R, Niculae, A, Thoma, N.H, Waldmann, H, Schlichting, I, Goody, R.S, Alexandrov, K. | | Deposit date: | 2002-05-21 | | Release date: | 2003-05-21 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structure of Rab Escort Protein-1 in Complex with Rab Geranylgeranyltransferase
Mol.Cell, 11, 2003
|
|
1AB3
 | | RIBOSOMAL PROTEIN S15 FROM THERMUS THERMOPHILUS, NMR, 26 STRUCTURES | | Descriptor: | RIBOSOMAL RNA BINDING PROTEIN S15 | | Authors: | Berglund, H, Rak, A, Serganov, A, Garber, M, Hard, T. | | Deposit date: | 1997-02-03 | | Release date: | 1997-04-01 | | Last modified: | 2022-02-16 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the ribosomal RNA binding protein S15 from Thermus thermophilus.
Nat.Struct.Biol., 4, 1997
|
|
4CP6
 | | The Crystal structure of Pneumococcal vaccine antigen PcpA | | Descriptor: | CHOLINE BINDING PROTEIN PCPA | | Authors: | Vallee, F, Steier, V, Oloo, E, Chawla, D, Vonrhein, C, Steinmetz, A, Mathieu, M, Rak, A, Mikol, V, Oomen, R. | | Deposit date: | 2014-01-31 | | Release date: | 2015-02-25 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.34 Å) | | Cite: | The Crystal Structure of Pneumoccocal Vaccine Antigen Pcpa
To be Published
|
|
8TYO
 | |
8TYL
 | |
3CPJ
 | | Crystal structure of Ypt31 in complex with yeast Rab-GDI | | Descriptor: | CHLORIDE ION, GTP-binding protein YPT31/YPT8, GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Kravchenko, S, Ignatev, A, Goody, R.S, Rak, A, Pylypenko, O. | | Deposit date: | 2008-03-31 | | Release date: | 2008-05-06 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | A structural model of the GDP dissociation inhibitor rab membrane extraction mechanism.
J.Biol.Chem., 283, 2008
|
|
3CPI
 | | Crystal structure of yeast Rab-GDI | | Descriptor: | Rab GDP-dissociation inhibitor | | Authors: | Kravchenko, S, Ignatev, A, Goody, R.S, Rak, A, Pylypenko, O. | | Deposit date: | 2008-03-31 | | Release date: | 2008-05-06 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | A structural model of the GDP dissociation inhibitor rab membrane extraction mechanism.
J.Biol.Chem., 283, 2008
|
|
3BW6
 | | Crystal structure of the longin domain of yeast Ykt6 | | Descriptor: | SULFATE ION, Synaptobrevin homolog YKT6 | | Authors: | Pylypenko, O, Schonichen, A, Ludwig, D, Ungermann, C, Goody, R.S, Rak, A, Geyer, M. | | Deposit date: | 2008-01-08 | | Release date: | 2008-04-01 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Farnesylation of the SNARE protein Ykt6 increases its stability and helical folding.
J.Mol.Biol., 377, 2008
|
|
3CPH
 | | Crystal structure of Sec4 in complex with Rab-GDI | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Rab GDP-dissociation inhibitor, ... | | Authors: | Kravchenko, S, Ignatev, A, Goody, R.S, Rak, A, Pylypenko, O. | | Deposit date: | 2008-03-31 | | Release date: | 2008-05-06 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | A structural model of the GDP dissociation inhibitor rab membrane extraction mechanism.
J.Biol.Chem., 283, 2008
|
|
5FHX
 | | CRYSTAL STRUCTURE OF CODV IN COMPLEX WITH IL4 AT 2.55 Ang. RESOLUTION. | | Descriptor: | Antibody fragment light chain, Interleukin-4, PHOSPHATE ION, ... | | Authors: | Vallee, F, Dupuy, A, Rak, A. | | Deposit date: | 2015-12-22 | | Release date: | 2016-03-30 | | Last modified: | 2018-10-24 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | CODV-Ig, a universal bispecific tetravalent and multifunctional immunoglobulin format for medical applications.
Mabs, 8, 2016
|
|
5HCG
 | | CRYSTAL STRUCTURE OF FREE-CODV. | | Descriptor: | CODV heavy-chain, CODV light chain | | Authors: | Vallee, F, Dupuy, A, Rak, A. | | Deposit date: | 2016-01-04 | | Release date: | 2016-03-30 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.68 Å) | | Cite: | CODV-Ig, a universal bispecific tetravalent and multifunctional immunoglobulin format for medical applications.
Mabs, 8, 2016
|
|
1DFE
 | | NMR STRUCTURE OF RIBOSOMAL PROTEIN L36 FROM THERMUS THERMOPHILUS | | Descriptor: | L36 RIBOSOMAL PROTEIN, ZINC ION | | Authors: | Hard, T, Rak, A, Allard, P, Kloo, L, Garber, M. | | Deposit date: | 1999-11-19 | | Release date: | 1999-12-01 | | Last modified: | 2022-02-16 | | Method: | SOLUTION NMR | | Cite: | The solution structure of ribosomal protein L36 from Thermus thermophilus reveals a zinc-ribbon-like fold.
J.Mol.Biol., 296, 2000
|
|
1DGZ
 | | RIBOSMAL PROTEIN L36 FROM THERMUS THERMOPHILUS: NMR STRUCTURE ENSEMBLE | | Descriptor: | PROTEIN (L36 RIBOSOMAL PROTEIN), ZINC ION | | Authors: | Hard, T, Rak, A, Allard, P, Kloo, L, Garber, M. | | Deposit date: | 1999-11-27 | | Release date: | 1999-12-08 | | Last modified: | 2022-02-16 | | Method: | SOLUTION NMR | | Cite: | The solution structure of ribosomal protein L36 from Thermus thermophilus reveals a zinc-ribbon-like fold.
J.Mol.Biol., 296, 2000
|
|
