5BX0
An Automated Microscale Thermophoresis Screening Approach for Fragment-Based Lead Discovery
Summary for 5BX0
Entry DOI | 10.2210/pdb5bx0/pdb |
Descriptor | Dual specificity mitogen-activated protein kinase kinase 1, ethyl 2H-indazole-5-carboxylate (2 entities in total) |
Functional Keywords | fragment screening, microscale thermophoresis, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome : Q02750 |
Total number of polymer chains | 1 |
Total formula weight | 39107.08 |
Authors | Vallee, F.,Steier, V.,Rak, A. (deposition date: 2015-06-08, release date: 2015-12-23, Last modification date: 2024-01-10) |
Primary citation | Linke, P.,Amaning, K.,Maschberger, M.,Vallee, F.,Steier, V.,Baaske, P.,Duhr, S.,Breitsprecher, D.,Rak, A. An Automated Microscale Thermophoresis Screening Approach for Fragment-Based Lead Discovery. J Biomol Screen, 21:414-421, 2016 Cited by PubMed: 26637553DOI: 10.1177/1087057115618347 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.93 Å) |
Structure validation
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