5BX0
An Automated Microscale Thermophoresis Screening Approach for Fragment-Based Lead Discovery
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Dual specificity mitogen-activated protein kinase kinase 1 | polymer | 348 | 38916.9 | 1 | UniProt (Q02750) Pfam (PF00069) | Homo sapiens (Human) | MKK1,ERK activator kinase 1,MAPK/ERK kinase 1,MEK 1 |
| 2 | B (A) | ethyl 2H-indazole-5-carboxylate | non-polymer | 190.2 | 1 | Chemie (4W5) |
Sequence modifications
A: 37 - 383 (UniProt: Q02750)
| PDB | External Database | Details |
|---|---|---|
| Gly 36 | - | expression tag |
| Asn 298 | Ser 298 | conflict |
| Lys 299 | Ser 299 | conflict |
| Lys 300 | Tyr 300 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 38916.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 190.2 | |
| All* | Total formula weight | 39107.1 |
