8K0B
 
 | |
4PXQ
 | | Crystal structure of D-glucuronyl C5-epimerase in complex with heparin hexasaccharide | | 分子名称: | 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, D-glucuronyl C5 epimerase B | | 著者 | Ke, J, Qin, Y, Gu, X, Tan, J, Brunzelle, J.S, Xu, H.E, Ding, K. | | 登録日 | 2014-03-24 | | 公開日 | 2015-01-14 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structural and Functional Study of d-Glucuronyl C5-epimerase.
J.Biol.Chem., 290, 2015
|
|
8J8Q
 | | Structure of the four-component Paf1 complex from Saccharomyces eubayanus | | 分子名称: | CDC73-like protein, CTR9-like protein, PAF1-like protein, ... | | 著者 | Wang, Z, Qin, Y, Zhou, Y, Cao, Y. | | 登録日 | 2023-05-02 | | 公開日 | 2023-05-24 | | 最終更新日 | 2023-06-14 | | 実験手法 | X-RAY DIFFRACTION (3.11 Å) | | 主引用文献 | Structural Basis of the Transcriptional Elongation Factor Paf1 Core Complex from Saccharomyces eubayanus .
Int J Mol Sci, 24, 2023
|
|
8J8P
 | | Structure of the four-component Paf1 complex from Saccharomyces eubayanus | | 分子名称: | CDC73-like protein, CTR9-like protein, PAF1-like protein, ... | | 著者 | Wang, Z, Qin, Y, Zhou, Y, Cao, Y. | | 登録日 | 2023-05-02 | | 公開日 | 2023-05-24 | | 最終更新日 | 2023-06-14 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural Basis of the Transcriptional Elongation Factor Paf1 Core Complex from Saccharomyces eubayanus .
Int J Mol Sci, 24, 2023
|
|
4PW2
 | | Crystal structure of D-glucuronyl C5 epimerase | | 分子名称: | CITRIC ACID, D-glucuronyl C5 epimerase B | | 著者 | Ke, J, Qin, Y, Gu, X, Brunzelle, J.S, Xu, H.E, Ding, K. | | 登録日 | 2014-03-18 | | 公開日 | 2015-01-14 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural and Functional Study of d-Glucuronyl C5-epimerase.
J.Biol.Chem., 290, 2015
|
|
5ADY
 | | Cryo-EM structures of the 50S ribosome subunit bound with HflX | | 分子名称: | 23S RRNA, 50S RIBOSOMAL PROTEIN L1, 50S RIBOSOMAL PROTEIN L10, ... | | 著者 | Zhang, Y, Mandava, C.S, Cao, W, Li, X, Zhang, D, Li, N, Zhang, Y, Zhang, X, Qin, Y, Mi, K, Lei, J, Sanyal, S, Gao, N. | | 登録日 | 2015-08-25 | | 公開日 | 2015-10-14 | | 最終更新日 | 2018-10-24 | | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | | 主引用文献 | Hflx is a Ribosome Splitting Factor Rescuing Stalled Ribosomes Under Stress Conditions
Nat.Struct.Mol.Biol., 22, 2015
|
|
3JCE
 | | Structure of Escherichia coli EF4 in pretranslocational ribosomes (Pre EF4) | | 分子名称: | 16S ribosomal RNA, 23 ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Zhang, D, Yan, K, Liu, G, Song, G, Luo, J, Shi, Y, Cheng, E, Wu, S, Jiang, T, Low, J, Gao, N, Qin, Y. | | 登録日 | 2015-12-01 | | 公開日 | 2016-01-13 | | 最終更新日 | 2023-08-02 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | EF4 disengages the peptidyl-tRNA CCA end and facilitates back-translocation on the 70S ribosome
Nat. Struct. Mol. Biol., 23, 2016
|
|
3JCD
 | | Structure of Escherichia coli EF4 in posttranslocational ribosomes (Post EF4) | | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Zhang, D, Yan, K, Liu, G, Song, G, Luo, J, Shi, Y, Cheng, E, Wu, S, Jiang, T, Low, J, Gao, N, Qin, Y. | | 登録日 | 2015-12-01 | | 公開日 | 2016-01-13 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | EF4 disengages the peptidyl-tRNA CCA end and facilitates back-translocation on the 70S ribosome
Nat. Struct. Mol. Biol., 23, 2016
|
|
3DEG
 | | Complex of elongating Escherichia coli 70S ribosome and EF4(LepA)-GMPPNP | | 分子名称: | 30S RNA helix 14, 30S RNA helix 8, 30S ribosomal protein S12, ... | | 著者 | Connell, S.R, Topf, M, Qin, Y, Wilson, D.N, Mielke, T, Fucini, P, Nierhaus, K.H, Spahn, C.M.T. | | 登録日 | 2008-06-10 | | 公開日 | 2008-08-19 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (10.9 Å) | | 主引用文献 | A new tRNA intermediate revealed on the ribosome during EF4-mediated back-translocation
Nat.Struct.Mol.Biol., 15, 2008
|
|
4TZ7
 | | Crystal structure of type I phosphatidylinositol 4-phosphate 5-kinase alpha from Zebrafish | | 分子名称: | Phosphatidylinositol-4-phosphate 5-kinase, type I, alpha | | 著者 | Hu, J, Qin, Y, Wang, J, Li, L, Wu, D, Ha, Y. | | 登録日 | 2014-07-09 | | 公開日 | 2015-09-02 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (3.31 Å) | | 主引用文献 | Resolution of structure of PIP5K1A reveals molecular mechanism for its regulation by dimerization and dishevelled.
Nat Commun, 6, 2015
|
|
7CPU
 | | Cryo-EM structure of 80S ribosome from mouse kidney | | 分子名称: | 40S ribosomal protein S10, 40S ribosomal protein S11, 40S ribosomal protein S13, ... | | 著者 | Huo, Y.G, He, X, Jiang, T, Qin, Y, Guo, X.J, Sha, J.H. | | 登録日 | 2020-08-08 | | 公開日 | 2022-02-02 | | 最終更新日 | 2023-01-11 | | 実験手法 | ELECTRON MICROSCOPY (2.82 Å) | | 主引用文献 | A male germ-cell-specific ribosome controls male fertility.
Nature, 612, 2022
|
|
8JJ6
 | | Structure of the NELF-BCE complex | | 分子名称: | NELF-E, Negative elongation factor B, Negative elongation factor complex member C/D | | 著者 | Wang, Z, Cao, Y, Qin, Y. | | 登録日 | 2023-05-29 | | 公開日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.72 Å) | | 主引用文献 | The crystal structure of the human NELF-B, NELF-C, and NELF-E trimeric complex
To Be Published
|
|
4M1K
 | |
4MYU
 | |
4MYT
 | |
7CPV
 | | Cryo-EM structure of 80S ribosome from mouse testis | | 分子名称: | 40S ribosomal protein S10, 40S ribosomal protein S11, 40S ribosomal protein S13, ... | | 著者 | Huo, Y.G, He, X, Jiang, T, Qin, Y, Guo, X.J, Sha, J.H. | | 登録日 | 2020-08-08 | | 公開日 | 2022-02-02 | | 最終更新日 | 2023-01-11 | | 実験手法 | ELECTRON MICROSCOPY (3.03 Å) | | 主引用文献 | A male germ-cell-specific ribosome controls male fertility.
Nature, 612, 2022
|
|
7N4V
 | | Structure of cholesterol-bound human NPC1L1 | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Li, X, Long, T. | | 登録日 | 2021-06-04 | | 公開日 | 2021-09-01 | | 最終更新日 | 2022-03-16 | | 実験手法 | ELECTRON MICROSCOPY (3.58 Å) | | 主引用文献 | Structures of dimeric human NPC1L1 provide insight into mechanisms for cholesterol absorption.
Sci Adv, 7, 2021
|
|
7N4X
 | | Structure of human NPC1L1 mutant-W347R | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | | 著者 | Li, X, Long, T. | | 登録日 | 2021-06-04 | | 公開日 | 2021-09-01 | | 最終更新日 | 2022-03-16 | | 実験手法 | ELECTRON MICROSCOPY (3.33 Å) | | 主引用文献 | Structures of dimeric human NPC1L1 provide insight into mechanisms for cholesterol absorption.
Sci Adv, 7, 2021
|
|
7N4U
 | | Structure of human NPC1L1 | | 分子名称: | (2R)-2,5,7,8-TETRAMETHYL-2-[(4R,8R)-4,8,12-TRIMETHYLTRIDECYL]CHROMAN-6-OL, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Li, X, Long, T. | | 登録日 | 2021-06-04 | | 公開日 | 2021-09-01 | | 最終更新日 | 2022-03-16 | | 実験手法 | ELECTRON MICROSCOPY (3.34 Å) | | 主引用文献 | Structures of dimeric human NPC1L1 provide insight into mechanisms for cholesterol absorption.
Sci Adv, 7, 2021
|
|
7SHN
 | | Cryo-EM structure of oleoyl-CoA-bound human peroxisomal fatty acid transporter ABCD1 | | 分子名称: | ATP-binding cassette sub-family D member 1, S-{(3R,5R,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9Z)-octadec-9-enethioate (non-preferred name) | | 著者 | Wang, R, Li, X. | | 登録日 | 2021-10-09 | | 公開日 | 2021-11-03 | | 最終更新日 | 2022-02-16 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structural basis of acyl-CoA transport across the peroxisomal membrane by human ABCD1.
Cell Res., 32, 2022
|
|
7SHM
 | |
7OFB
 | | Keap1 kelch domain bound to a small molecule fragment | | 分子名称: | DIMETHYL SULFOXIDE, Kelch-like ECH-associated protein 1, SULFATE ION, ... | | 著者 | Narayanan, D, Bach, A, Gajhede, M. | | 登録日 | 2021-05-04 | | 公開日 | 2022-11-02 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Development of Noncovalent Small-Molecule Keap1-Nrf2 Inhibitors by Fragment-Based Drug Discovery.
J.Med.Chem., 65, 2022
|
|
7OFC
 | | Keap1 kelch domain bound to a small molecule fragment | | 分子名称: | DIMETHYL SULFOXIDE, Kelch-like ECH-associated protein 1, SULFATE ION, ... | | 著者 | Narayanan, D, Bach, A, Gajhede, M. | | 登録日 | 2021-05-04 | | 公開日 | 2022-11-02 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | | 主引用文献 | Development of Noncovalent Small-Molecule Keap1-Nrf2 Inhibitors by Fragment-Based Drug Discovery.
J.Med.Chem., 65, 2022
|
|
7OFF
 | | Keap1 kelch domain bound to a small molecule inhibitor of the Keap1-Nrf2 protein-protein interaction | | 分子名称: | (2~{R})-2-[(9-oxidanylidenefluoren-4-yl)carbonylamino]-2-phenyl-ethanoic acid, DIMETHYL SULFOXIDE, Kelch-like ECH-associated protein 1, ... | | 著者 | Narayanan, D, Bach, A, Gajhede, M. | | 登録日 | 2021-05-04 | | 公開日 | 2022-11-02 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.37 Å) | | 主引用文献 | Development of Noncovalent Small-Molecule Keap1-Nrf2 Inhibitors by Fragment-Based Drug Discovery.
J.Med.Chem., 65, 2022
|
|
7OFA
 | | Keap1 kelch domain bound to a small molecule fragment | | 分子名称: | 2,6-bis(chloranyl)-5-fluoranyl-pyridine-3-carboxylic acid, DIMETHYL SULFOXIDE, Kelch-like ECH-associated protein 1 | | 著者 | Narayanan, D, Bach, A, Gajhede, M. | | 登録日 | 2021-05-04 | | 公開日 | 2022-11-02 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | | 主引用文献 | Development of Noncovalent Small-Molecule Keap1-Nrf2 Inhibitors by Fragment-Based Drug Discovery.
J.Med.Chem., 65, 2022
|
|
