7OFF

Keap1 kelch domain bound to a small molecule inhibitor of the Keap1-Nrf2 protein-protein interaction

Summary for 7OFF

Entry DOI	10.2210/pdb7off/pdb
Descriptor	Kelch-like ECH-associated protein 1, SULFATE ION, DIMETHYL SULFOXIDE, ... (5 entities in total)
Functional Keywords	keap1, nrf2, oxidative stress, small molecule complex, maybridge, peptide binding protein
Biological source	Mus musculus (Mouse)
Total number of polymer chains	1
Total formula weight	34614.98
Authors	Narayanan, D.,Bach, A.,Gajhede, M. (deposition date: 2021-05-04, release date: 2022-11-02, Last modification date: 2024-01-31)
Primary citation	Narayanan, D.,Tran, K.T.,Pallesen, J.S.,Solbak, S.M.O.,Qin, Y.,Mukminova, E.,Luchini, M.,Vasilyeva, K.O.,Gonzalez Chichon, D.,Goutsiou, G.,Poulsen, C.,Haapanen, N.,Popowicz, G.M.,Sattler, M.,Olagnier, D.,Gajhede, M.,Bach, A. Development of Noncovalent Small-Molecule Keap1-Nrf2 Inhibitors by Fragment-Based Drug Discovery. J.Med.Chem., 65:14481-14526, 2022 Cited by PubMed: 36263945 DOI: 10.1021/acs.jmedchem.2c00830 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.37 Å)

Structure validation