7M98
| ATAD2 bromodomain complexed with histone H4K5ac (res 1-10) ligand | 分子名称: | ATPase family AAA domain-containing protein 2, Histone H4 | 著者 | Malone, K.L, Phillips, M, Nix, J.C, Glass, K.C. | 登録日 | 2021-03-30 | 公開日 | 2021-09-22 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Coordination of Di-Acetylated Histone Ligands by the ATAD2 Bromodomain. Int J Mol Sci, 22, 2021
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2A1B
| Carboxysome shell protein ccmK2 | 分子名称: | Carbon dioxide concentrating mechanism protein ccmK homolog 2 | 著者 | Kerfeld, C.A, Sawaya, M.R, Tanaka, S, Nguyen, C.V, Phillips, M, Beeby, M, Yeates, T.O. | 登録日 | 2005-06-20 | 公開日 | 2005-08-09 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Protein structures forming the shell of primitive bacterial organelles Science, 309, 2005
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2A10
| carboxysome shell protein ccmK4 | 分子名称: | Carbon dioxide concentrating mechanism protein ccmK homolog 4 | 著者 | Kerfeld, C.A, Sawaya, M.R, Tanaka, S, Nguyen, C.V, Phillips, M, Beeby, M, Yeates, T.O. | 登録日 | 2005-06-17 | 公開日 | 2005-08-09 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.803 Å) | 主引用文献 | Protein structures forming the shell of primitive bacterial organelles Science, 309, 2005
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2A18
| carboxysome shell protein ccmK4, crystal form 2 | 分子名称: | AMMONIUM ION, Carbon dioxide concentrating mechanism protein ccmK homolog 4 | 著者 | Kerfeld, C.A, Sawaya, M.R, Tanaka, S, Nguyen, C.V, Phillips, M, Beeby, M, Yeates, T.O. | 登録日 | 2005-06-18 | 公開日 | 2005-08-09 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | 主引用文献 | Protein structures forming the shell of primitive bacterial organelles Science, 309, 2005
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1F0M
| MONOMERIC STRUCTURE OF THE HUMAN EPHB2 SAM (STERILE ALPHA MOTIF) DOMAIN | 分子名称: | EPHRIN TYPE-B RECEPTOR 2 | 著者 | Thanos, C.D, Faham, S, Goodwill, K.E, Cascio, D, Phillips, M, Bowie, J.U. | 登録日 | 2000-05-16 | 公開日 | 2000-07-04 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Monomeric structure of the human EphB2 sterile alpha motif domain. J.Biol.Chem., 274, 1999
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1M5Q
| Crystal structure of a novel Sm-like archaeal protein from Pyrobaculum aerophilum | 分子名称: | ACETIC ACID, CADMIUM ION, GLYCEROL, ... | 著者 | Mura, C, Phillips, M, Kozhukhovsky, A, Eisenberg, D. | 登録日 | 2002-07-09 | 公開日 | 2003-03-18 | 最終更新日 | 2017-05-17 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure and assembly of an augmented Sm-like archaeal protein 14-mer Proc.Natl.Acad.Sci.USA, 100, 2003
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1NBU
| 7,8-Dihydroneopterin Aldolase Complexed with Product From Mycobacterium Tuberculosis | 分子名称: | 2-AMINO-6-HYDROXYMETHYL-7,8-DIHYDRO-3H-PTERIDIN-4-ONE, Probable dihydroneopterin aldolase | 著者 | Goulding, C.W, Apostol, M.I, Sawaya, M.R, Phillips, M, Parseghian, A, Eisenberg, D, TB Structural Genomics Consortium (TBSGC) | 登録日 | 2002-12-03 | 公開日 | 2004-01-13 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Regulation by oligomerization in a mycobacterial folate biosynthetic enzyme. J.Mol.Biol., 349, 2005
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2H3K
| Solution Structure of the first NEAT domain of IsdH | 分子名称: | Haptoglobin-binding surface anchored protein | 著者 | Pilpa, R.M, Fadeev, E.A, Villareal, V.A, Wong, M.A, Phillips, M, Clubb, R.T. | 登録日 | 2006-05-22 | 公開日 | 2006-08-22 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of the NEAT (NEAr Transporter) domain from IsdH/HarA: the human hemoglobin receptor in Staphylococcus aureus. J.Mol.Biol., 360, 2006
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1LX8
| Regulation of directionality in bacteriophage lambda site-specific recombination: structure of the Xis protein | 分子名称: | Excisionase | 著者 | Sam, M.D, Papagiannis, C, Connolly, K.M, Corselli, L, Iwahara, J, Lee, J, Phillips, M, Wojciak, J.M, Johnson, R.C, Clubb, R.T. | 登録日 | 2002-06-04 | 公開日 | 2003-06-10 | 最終更新日 | 2021-10-27 | 実験手法 | SOLUTION NMR | 主引用文献 | Regulation of directionality in bacteriophage lambda site-specific recombination: structure of the Xis protein J.Mol.Biol., 324, 2002
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5BOO
| Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with Inhibitor DSM265 | 分子名称: | 2-(1,1-difluoroethyl)-5-methyl-N-[4-(pentafluoro-lambda~6~-sulfanyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine, Dihydroorotate dehydrogenase (quinone), mitochondrial, ... | 著者 | Phillips, M, Deng, X, Tomchick, D. | 登録日 | 2015-05-27 | 公開日 | 2015-07-29 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria. Sci Transl Med, 7, 2015
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5DEL
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5WDM
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1LOJ
| Crystal structure of a Methanobacterial Sm-like archaeal protein (SmAP1) bound to uridine-5'-monophosphate (UMP) | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, URIDINE, URIDINE-5'-MONOPHOSPHATE, ... | 著者 | Mura, C, Kozhukhovsky, A, Eisenberg, D. | 登録日 | 2002-05-06 | 公開日 | 2003-03-25 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | The oligomerization and ligand-binding properties of Sm-like archaeal proteins (SmAPs) Protein Sci., 12, 2003
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7UT5
| Acinetobacter baumannii dihydroorotate dehydrogenase bound with inhibitor DSM186 | 分子名称: | (4R)-7-methyl-N-[4-(pentafluoro-lambda~6~-sulfanyl)phenyl]imidazo[1,2-a]pyrimidin-5-amine, Dihydroorotate dehydrogenase (quinone), FLAVIN MONONUCLEOTIDE, ... | 著者 | Deng, X, Phillips, M, Tomchick, D. | 登録日 | 2022-04-26 | 公開日 | 2022-12-28 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Repurposed dihydroorotate dehydrogenase inhibitors with efficacy against drug-resistant Acinetobacter baumannii. Proc.Natl.Acad.Sci.USA, 119, 2022
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5TBO
| Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with Inhibitor DSM421 | 分子名称: | 2-(1,1-difluoroethyl)-5-methyl-N-[6-(trifluoromethyl)pyridin-3-yl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine, Dihydroorotate dehydrogenase (quinone), mitochondrial, ... | 著者 | Deng, X, Phillips, M. | 登録日 | 2016-09-12 | 公開日 | 2016-09-28 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.151 Å) | 主引用文献 | A Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Improved Drug-like Properties for Treatment and Prevention of Malaria. ACS Infect Dis, 2, 2016
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7RL2
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3SFK
| Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with Inhibitor DSM267 | 分子名称: | 2-(1,1-difluoroethyl)-5-methyl-N-[4-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine, Dihydroorotate dehydrogenase (quinone), mitochondrial, ... | 著者 | Deng, X, Phillips, M. | 登録日 | 2011-06-13 | 公開日 | 2011-07-06 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors with Clinical Candidate Potential. J.Med.Chem., 54, 2011
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5FI8
| Crystal structure of plasmodium falciparum dihydroorotate dehydrogenase bounded with DSM422 (Tetrahydro-2-naphthyl and 2-indanyl triazolopyrimidine) | 分子名称: | 2-[1,1-bis(fluoranyl)ethyl]-~{N}-[(2~{S})-7-bromanyl-1,2,3,4-tetrahydronaphthalen-2-yl]-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine, Dihydroorotate dehydrogenase (quinone), mitochondrial, ... | 著者 | Deng, X, Kokkonda, S, Tomchick, D, Phillips, M. | 登録日 | 2015-12-22 | 公開日 | 2016-05-18 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | 主引用文献 | Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity. J.Med.Chem., 59, 2016
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3UE5
| ECP-cleaved Actin in complex with Spir domain D | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Actin, alpha skeletal muscle, ... | 著者 | Chen, C, Phillips, M, Sawaya, M.R, Ralston, C.Y, Quinlan, M.E. | 登録日 | 2011-10-28 | 公開日 | 2012-02-15 | 最終更新日 | 2012-04-11 | 実験手法 | X-RAY DIFFRACTION (2.76 Å) | 主引用文献 | Multiple Forms of Spire-Actin Complexes and their Functional Consequences. J.Biol.Chem., 287, 2012
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6VTN
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6VTY
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4RX0
| Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with Inhibitor DSM265 | 分子名称: | 2-(1,1-difluoroethyl)-5-methyl-N-[4-(pentafluoro-lambda~6~-sulfanyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine, Dihydroorotate dehydrogenase (quinone), mitochondrial, ... | 著者 | Deng, X, Phillips, M, Tomchick, D. | 登録日 | 2014-12-08 | 公開日 | 2015-07-29 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria. Sci Transl Med, 7, 2015
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6VEO
| ATAD2B bromodomain in complex with 4-({[(3R,4R)-4-{[3-methyl-5-(5-methylpyridin-3-yl)-2-oxo-1,2-dihydro-1,7-naphthyridin-8-yl]amino}piperidin-3-yl]oxy}methyl)-1lambda~6~-thiane-1,1-dione (compound 38) | 分子名称: | 4-({[(3R,4R)-4-{[3-methyl-5-(5-methylpyridin-3-yl)-2-oxo-1,2-dihydro-1,7-naphthyridin-8-yl]amino}piperidin-3-yl]oxy}methyl)-1lambda~6~-thiane-1,1-dione, ATPase family AAA domain-containing protein 2B, SULFATE ION | 著者 | Glass, K.C. | 登録日 | 2020-01-02 | 公開日 | 2020-10-28 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural Insights into the Recognition of Mono- and Diacetylated Histones by the ATAD2B Bromodomain. J.Med.Chem., 63, 2020
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4EFH
| Acanthamoeba Actin complex with Spir domain D | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin-1, CALCIUM ION, ... | 著者 | Chen, C, Phillips, M, Sawaya, M.R, Quinlan, M.E. | 登録日 | 2012-03-29 | 公開日 | 2012-04-11 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | 主引用文献 | Multiple Forms of Spire-Actin Complexes and their Functional Consequences. J.Biol.Chem., 287, 2012
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7KH2
| Structure of N-citrylornithine decarboxylase bound with PLP | 分子名称: | GLYCEROL, N-citrylornithine decarboxylase, PYRIDOXAL-5'-PHOSPHATE, ... | 著者 | Deng, X, Tomchick, D, Phillips, M, Michael, A. | 登録日 | 2020-10-19 | 公開日 | 2020-12-16 | 最終更新日 | 2021-07-28 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Alternative pathways utilize or circumvent putrescine for biosynthesis of putrescine-containing rhizoferrin. J.Biol.Chem., 296, 2020
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