6VEO

ATAD2B bromodomain in complex with 4-({[(3R,4R)-4-{[3-methyl-5-(5-methylpyridin-3-yl)-2-oxo-1,2-dihydro-1,7-naphthyridin-8-yl]amino}piperidin-3-yl]oxy}methyl)-1lambda~6~-thiane-1,1-dione (compound 38)

Summary for 6VEO

Entry DOI	10.2210/pdb6veo/pdb
Descriptor	ATPase family AAA domain-containing protein 2B, SULFATE ION, 4-({[(3R,4R)-4-{[3-methyl-5-(5-methylpyridin-3-yl)-2-oxo-1,2-dihydro-1,7-naphthyridin-8-yl]amino}piperidin-3-yl]oxy}methyl)-1lambda~6~-thiane-1,1-dione, ... (4 entities in total)
Functional Keywords	bromodomain, epigenetics, nuclear protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	16529.85
Authors	Glass, K.C. (deposition date: 2020-01-02, release date: 2020-10-28, Last modification date: 2023-10-11)
Primary citation	Lloyd, J.T.,McLaughlin, K.,Lubula, M.Y.,Gay, J.C.,Dest, A.,Gao, C.,Phillips, M.,Tonelli, M.,Cornilescu, G.,Marunde, M.R.,Evans, C.M.,Boyson, S.P.,Carlson, S.,Keogh, M.C.,Markley, J.L.,Frietze, S.,Glass, K.C. Structural Insights into the Recognition of Mono- and Diacetylated Histones by the ATAD2B Bromodomain. J.Med.Chem., 63:12799-12813, 2020 Cited by PubMed: 33084328 DOI: 10.1021/acs.jmedchem.0c01178 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation