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5DEL

Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with Inhibitor DSM59

Replaces:  4RYH
Summary for 5DEL
Entry DOI10.2210/pdb5del/pdb
DescriptorDihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (7 entities in total)
Functional Keywordsalpha/beta barrel, mitochondrial membrane, fmn, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological sourcePlasmodium falciparum
Cellular locationMitochondrion inner membrane ; Single-pass membrane protein : Q08210
Total number of polymer chains1
Total formula weight46737.09
Authors
Phillips, M.,Deng, X. (deposition date: 2015-08-25, release date: 2015-10-07, Last modification date: 2023-09-27)
Primary citationDeng, X.,Matthews, D.,Rathod, P.K.,Phillips, M.A.
The X-ray structure of Plasmodium falciparum dihydroorotate dehydrogenase bound to a potent and selective N-phenylbenzamide inhibitor reveals novel binding-site interactions.
Acta Crystallogr.,Sect.F, 71:553-559, 2015
Cited by
PubMed: 25945708
DOI: 10.1107/S2053230X15000989
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.2 Å)
Structure validation

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