1TUP
| TUMOR SUPPRESSOR P53 COMPLEXED WITH DNA | Descriptor: | DNA (5'-D(*AP*TP*AP*AP*TP*TP*GP*GP*GP*CP*AP*AP*GP*TP*CP*TP*A P*GP*GP*AP*A)-3'), DNA (5'-D(*TP*TP*TP*CP*CP*TP*AP*GP*AP*CP*TP*TP*GP*CP*CP*CP*A P*AP*TP*TP*A)-3'), PROTEIN (P53 TUMOR SUPPRESSOR ), ... | Authors: | Cho, Y, Gorina, S, Jeffrey, P.D, Pavletich, N.P. | Deposit date: | 1995-07-11 | Release date: | 1995-07-11 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations. Science, 265, 1994
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1BI8
| MECHANISM OF G1 CYCLIN DEPENDENT KINASE INHIBITION FROM THE STRUCTURES CDK6-P19INK4D INHIBITOR COMPLEX | Descriptor: | CYCLIN-DEPENDENT KINASE 6, CYCLIN-DEPENDENT KINASE INHIBITOR | Authors: | Russo, A.A, Tong, L, Lee, J.O, Jeffrey, P.D, Pavletich, N.P. | Deposit date: | 1998-06-22 | Release date: | 1999-01-13 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a. Nature, 395, 1998
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1BI7
| MECHANISM OF G1 CYCLIN DEPENDENT KINASE INHIBITION FROM THE STRUCTURE OF THE CDK6-P16INK4A TUMOR SUPPRESSOR COMPLEX | Descriptor: | CYCLIN-DEPENDENT KINASE 6, MULTIPLE TUMOR SUPPRESSOR | Authors: | Russo, A.A, Tong, L, Lee, J.O, Jeffrey, P.D, Pavletich, N.P. | Deposit date: | 1998-06-22 | Release date: | 1999-01-13 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a. Nature, 395, 1998
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1C3P
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1BYQ
| HSP90 N-TERMINAL DOMAIN BOUND TO ADP-MG | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PROTEIN (HEAT SHOCK PROTEIN 90) | Authors: | Russo, A.A, Pavletich, N.P. | Deposit date: | 1998-10-19 | Release date: | 1998-10-28 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis. J.Cell Biol., 143, 1998
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1C3S
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1C26
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1C3R
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1C4Z
| STRUCTURE OF AN E6AP-UBCH7 COMPLEX: INSIGHTS INTO THE UBIQUITINATION PATHWAY | Descriptor: | UBIQUITIN CONJUGATING ENZYME E2, UBIQUITIN-PROTEIN LIGASE E3A | Authors: | Huang, L, Kinnucan, E, Wang, G, Beaudenon, S, Howley, P.M, Huibregtse, J.M, Pavletich, N.P. | Deposit date: | 1999-10-14 | Release date: | 1999-11-17 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade. Science, 286, 1999
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5EAY
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5EAW
| Crystal structure of Dna2 nuclease-helicase | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA replication ATP-dependent helicase/nuclease DNA2, IRON/SULFUR CLUSTER | Authors: | Zhou, C, Pourmal, S, Pavletich, N.P. | Deposit date: | 2015-10-17 | Release date: | 2015-11-18 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Dna2 nuclease-helicase structure, mechanism and regulation by Rpa. Elife, 4, 2015
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2OVQ
| Structure of the Skp1-Fbw7-CyclinEdegC complex | Descriptor: | F-box/WD repeat protein 7, S-phase kinase-associated protein 1A, SULFATE ION, ... | Authors: | Hao, B, Oehlmann, S, Sowa, M.E, Harper, J.W, Pavletich, N.P. | Deposit date: | 2007-02-14 | Release date: | 2007-04-24 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure of a Fbw7-Skp1-Cyclin E Complex: Multisite-Phosphorylated Substrate Recognition by SCF Ubiquitin Ligases Mol.Cell, 26, 2007
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2OVP
| Structure of the Skp1-Fbw7 complex | Descriptor: | F-box/WD repeat protein 7, S-phase kinase-associated protein 1A | Authors: | Hao, B, Oehlmann, S, Sowa, M.E, Harper, J.W, Pavletich, N.P. | Deposit date: | 2007-02-14 | Release date: | 2007-04-24 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structure of a Fbw7-Skp1-Cyclin E Complex: Multisite-Phosphorylated Substrate Recognition by SCF Ubiquitin Ligases Mol.Cell, 26, 2007
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5EAX
| Crystal structure of Dna2 in complex with an ssDNA | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA (5'-D(*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), DNA replication ATP-dependent helicase/nuclease DNA2, ... | Authors: | Zhou, C, Pourmal, S, Pavletich, N.P. | Deposit date: | 2015-10-17 | Release date: | 2015-11-18 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (3.05 Å) | Cite: | Dna2 nuclease-helicase structure, mechanism and regulation by Rpa. Elife, 4, 2015
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5EAN
| Crystal structure of Dna2 in complex with a 5' overhang DNA | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, DNA (5'-D(P*AP*CP*TP*CP*TP*GP*CP*CP*AP*AP*GP*AP*GP*GP*A)-3'), ... | Authors: | Zhou, C, Pourmal, S, Pavletich, N.P. | Deposit date: | 2015-10-16 | Release date: | 2015-11-18 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.36 Å) | Cite: | Dna2 nuclease-helicase structure, mechanism and regulation by Rpa. Elife, 4, 2015
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2OVR
| Structure of the Skp1-Fbw7-CyclinEdegN complex | Descriptor: | F-box/WD repeat protein 7, S-phase kinase-associated protein 1A, SULFATE ION, ... | Authors: | Hao, B, Oehlmann, S, Sowa, M.E, Harper, J.W, Pavletich, N.P. | Deposit date: | 2007-02-14 | Release date: | 2007-04-24 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of a Fbw7-Skp1-Cyclin E Complex: Multisite-Phosphorylated Substrate Recognition by SCF Ubiquitin Ligases Mol.Cell, 26, 2007
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2QSH
| Crystal structure of Rad4-Rad23 bound to a mismatch DNA | Descriptor: | DNA repair protein RAD4, UV excision repair protein RAD23, bottom strand of the mismatch DNA, ... | Authors: | Min, J.-H, Pavletich, N.P. | Deposit date: | 2007-07-31 | Release date: | 2007-10-02 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.805 Å) | Cite: | Recognition of DNA damage by the Rad4 nucleotide excision repair protein Nature, 449, 2007
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2QSG
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2QSF
| Crystal structure of the Rad4-Rad23 complex | Descriptor: | DNA repair protein RAD4, UV excision repair protein RAD23 | Authors: | Min, J.-H, Pavletich, N.P. | Deposit date: | 2007-07-31 | Release date: | 2007-10-02 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Recognition of DNA damage by the Rad4 nucleotide excision repair protein Nature, 449, 2007
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1T4W
| Structural Differences in the DNA Binding Domains of Human p53 and its C. elegans Ortholog Cep-1: Structure of C. elegans Cep-1 | Descriptor: | C.Elegans p53 tumor suppressor-like transcription factor, ZINC ION | Authors: | Huyen, Y, Jeffrey, P.D, Derry, W.B, Rothman, J.H, Pavletich, N.P, Stavridi, E.S, Halazonetis, T.D. | Deposit date: | 2004-04-30 | Release date: | 2004-07-20 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural Differences in the DNA Binding Domains of Human p53 and Its C. elegans Ortholog Cep-1. Structure, 12, 2004
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1VCB
| THE VHL-ELONGINC-ELONGINB STRUCTURE | Descriptor: | PROTEIN (ELONGIN B), PROTEIN (ELONGIN C), PROTEIN (VHL) | Authors: | Stebbins, C.E, Kaelin, W.G, Pavletich, N.P. | Deposit date: | 1999-03-13 | Release date: | 1999-04-21 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function. Science, 284, 1999
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1YCQ
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1YGS
| CRYSTAL STRUCTURE OF THE SMAD4 TUMOR SUPPRESSOR C-TERMINAL DOMAIN | Descriptor: | SMAD4 | Authors: | Shi, Y, Hata, A, Lo, R.S, Massague, J, Pavletich, N.P. | Deposit date: | 1997-10-03 | Release date: | 1998-07-08 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | A structural basis for mutational inactivation of the tumour suppressor Smad4. Nature, 388, 1997
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1YCS
| P53-53BP2 COMPLEX | Descriptor: | 53BP2, P53, ZINC ION | Authors: | Gorina, S, Pavletich, N.P. | Deposit date: | 1996-09-30 | Release date: | 1997-11-19 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2. Science, 274, 1996
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1YCR
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