3LPI
| Structure of BACE Bound to SCH745132 | 分子名称: | Beta-secretase 1, L(+)-TARTARIC ACID, N'-{(1S,2S)-1-(3,5-difluorobenzyl)-2-hydroxy-2-[(2R)-4-(phenylsulfonyl)piperazin-2-yl]ethyl}-5-methyl-N,N-dipropylbenzene-1,3-dicarboxamide | 著者 | Strickland, C, Cumming, J. | 登録日 | 2010-02-05 | 公開日 | 2010-04-14 | 最終更新日 | 2017-11-01 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Piperazine sulfonamide BACE1 inhibitors: design, synthesis, and in vivo characterization. Bioorg.Med.Chem.Lett., 20, 2010
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7XSV
| Crystal Structures of PIM1 in Complex with Macrocyclic Compound H3 | 分子名称: | 8-Methyl-2,5,20-trioxa-8,13,17-triazatetracyclo[11.10.2.014,19.021,25]pentacosa-1(24),14(19),15,17,21(25),22-hexaene, Serine/threonine-protein kinase pim-1 | 著者 | Shen, C, Xie, Y, Ren, X, Zhou, Y, Niu, H. | 登録日 | 2022-05-15 | 公開日 | 2022-07-13 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.66 Å) | 主引用文献 | Design, synthesis, and bioactivity evaluation of macrocyclic benzo[b]pyrido[4,3-e][1,4]oxazine derivatives as novel Pim-1 kinase inhibitors. Bioorg.Med.Chem.Lett., 72, 2022
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3LPK
| Structure of BACE Bound to SCH747123 | 分子名称: | Beta-secretase 1, L(+)-TARTARIC ACID, N-[(1S,2S)-1-(3,5-difluorobenzyl)-2-hydroxy-2-{(2R)-4-[(3-methylphenyl)sulfonyl]piperazin-2-yl}ethyl]-3-{[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]carbonyl}-5-methylbenzamide | 著者 | Strickland, C, Cumming, J. | 登録日 | 2010-02-05 | 公開日 | 2010-04-14 | 最終更新日 | 2017-11-01 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Piperazine sulfonamide BACE1 inhibitors: design, synthesis, and in vivo characterization. Bioorg.Med.Chem.Lett., 20, 2010
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3LNK
| Structure of BACE bound to SCH743813 | 分子名称: | Beta-secretase 1, L(+)-TARTARIC ACID, N'-{(1S,2S)-1-(3,5-difluorobenzyl)-2-hydroxy-2-[(2R)-4-(phenylcarbonyl)piperazin-2-yl]ethyl}-5-methyl-N,N-dipropylbenzene-1,3-dicarboxamide | 著者 | Orth, P, Cumming, J. | 登録日 | 2010-02-02 | 公開日 | 2010-04-14 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Piperazine sulfonamide BACE1 inhibitors: design, synthesis, and in vivo characterization. Bioorg.Med.Chem.Lett., 20, 2010
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3LPJ
| Structure of BACE Bound to SCH743641 | 分子名称: | Beta-secretase 1, L(+)-TARTARIC ACID, N'-[(1S,2S)-2-[(2R)-4-benzylpiperazin-2-yl]-1-(3,5-difluorobenzyl)-2-hydroxyethyl]-5-methyl-N,N-dipropylbenzene-1,3-dicarboxamide | 著者 | Strickland, C, Cumming, J. | 登録日 | 2010-02-05 | 公開日 | 2010-04-14 | 最終更新日 | 2017-11-01 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | Piperazine sulfonamide BACE1 inhibitors: design, synthesis, and in vivo characterization. Bioorg.Med.Chem.Lett., 20, 2010
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7V2Y
| cryo-EM structure of yeast THO complex with Sub2 | 分子名称: | ATP-dependent RNA helicase SUB2, Protein TEX1, THO complex subunit 2, ... | 著者 | Chen, C, Tan, M, Wu, Z, Wu, J, Lei, M. | 登録日 | 2021-08-10 | 公開日 | 2022-07-27 | 最終更新日 | 2023-02-01 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural and functional insights into R-loop prevention and mRNA export by budding yeast THO-Sub2 complex. Sci Bull (Beijing), 66, 2021
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7V2W
| protomer structure from the dimer of yeast THO complex | 分子名称: | Protein TEX1, THO complex subunit 2, THO complex subunit HPR1, ... | 著者 | Chen, C, Tan, M, Wu, Z, Wu, J, Lei, M. | 登録日 | 2021-08-10 | 公開日 | 2022-07-27 | 最終更新日 | 2023-02-01 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural and functional insights into R-loop prevention and mRNA export by budding yeast THO-Sub2 complex. Sci Bull (Beijing), 66, 2021
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7V9A
| biogenesis module of human telomerase holoenzyme | 分子名称: | H/ACA ribonucleoprotein complex subunit 1, H/ACA ribonucleoprotein complex subunit 2, H/ACA ribonucleoprotein complex subunit 3, ... | 著者 | Wan, F, Ding, Y, Yang, L, Wu, Z, Wu, J, Lei, M. | 登録日 | 2021-08-24 | 公開日 | 2022-03-30 | 実験手法 | ELECTRON MICROSCOPY (3.94 Å) | 主引用文献 | Zipper head mechanism of telomere synthesis by human telomerase. Cell Res., 31, 2021
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7V99
| catalytic core of human telomerase holoenzyme | 分子名称: | Histone H2A type 1-B/E, Histone H2B type 1-K, Primer DNA, ... | 著者 | Wan, F, Ding, Y, Yang, L, Wu, Z, Wu, J, Lei, M. | 登録日 | 2021-08-24 | 公開日 | 2022-03-30 | 実験手法 | ELECTRON MICROSCOPY (3.54 Å) | 主引用文献 | Zipper head mechanism of telomere synthesis by human telomerase. Cell Res., 31, 2021
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5H48
| Crystal structure of Cbln1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cerebellin-1 | 著者 | Zhong, C, Shen, J, Zhang, H, Ding, J. | 登録日 | 2016-10-31 | 公開日 | 2017-09-06 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Cbln1 and Cbln4 Are Structurally Similar but Differ in GluD2 Binding Interactions. Cell Rep, 20, 2017
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5H4C
| Crystal structure of Cbln4 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Protein Cbln4 | 著者 | Zhong, C, Shen, J, Zhang, H, Ding, J. | 登録日 | 2016-10-31 | 公開日 | 2017-09-06 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Cbln1 and Cbln4 Are Structurally Similar but Differ in GluD2 Binding Interactions. Cell Rep, 20, 2017
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5H49
| Crystal structure of Cbln1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cerebellin-1 | 著者 | Zhong, C, Shen, J, Zhang, H, Ding, J. | 登録日 | 2016-10-31 | 公開日 | 2017-09-13 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Cbln1 and Cbln4 Are Structurally Similar but Differ in GluD2 Binding Interactions. Cell Rep, 20, 2017
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8H77
| Hsp90-AhR-p23-XAP2 complex | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, AH receptor-interacting protein, Aryl hydrocarbon receptor, ... | 著者 | Wen, Z.L, Zhai, Y.J, Zhu, Y, Sun, F. | 登録日 | 2022-10-19 | 公開日 | 2023-01-04 | 最終更新日 | 2023-03-22 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Cryo-EM structure of the cytosolic AhR complex. Structure, 31, 2023
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8HNZ
| Crystal structure of cytochrome P450 NasF5053 mutant E73S complexed with 6FCWP | 分子名称: | (3~{S},8~{a}~{S})-3-[(5-fluoranyl-1~{H}-indol-3-yl)methyl]-2,3,6,7,8,8~{a}-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione, CALCIUM ION, Cytochrome P450-F5053, ... | 著者 | Ma, B.D, Tian, W, Qu, X, Kong, X.D. | 登録日 | 2022-12-09 | 公開日 | 2023-04-19 | 最終更新日 | 2023-07-12 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Engineering the Substrate Specificity of a P450 Dimerase Enables the Collective Biosynthesis of Heterodimeric Tryptophan-Containing Diketopiperazines. Angew.Chem.Int.Ed.Engl., 62, 2023
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8HO1
| Crystal structure of cytochrome P450 NasF5053 mutant F387G | 分子名称: | CALCIUM ION, Cytochrome P450-F5053, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Ma, B.D, Tian, W, Qu, X, Kong, X.D. | 登録日 | 2022-12-09 | 公開日 | 2023-04-19 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Engineering the Substrate Specificity of a P450 Dimerase Enables the Collective Biosynthesis of Heterodimeric Tryptophan-Containing Diketopiperazines. Angew.Chem.Int.Ed.Engl., 62, 2023
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8HO0
| Crystal structure of cytochrome P450 NasF5053 mutant E73S complexed with 8FCWP | 分子名称: | (3~{S},8~{a}~{S})-3-[(7-fluoranyl-1~{H}-indol-3-yl)methyl]-2,3,6,7,8,8~{a}-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione, CALCIUM ION, Cytochrome P450-F5053, ... | 著者 | Ma, B.D, Tian, W, Qu, X, Kong, X.D. | 登録日 | 2022-12-09 | 公開日 | 2023-04-19 | 最終更新日 | 2023-07-12 | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | 主引用文献 | Engineering the Substrate Specificity of a P450 Dimerase Enables the Collective Biosynthesis of Heterodimeric Tryptophan-Containing Diketopiperazines. Angew.Chem.Int.Ed.Engl., 62, 2023
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8HNY
| Crystal structure of cytochrome P450 NasF5053 mutant E73S complexed with 5FCWP | 分子名称: | (3~{S},8~{a}~{S})-3-[(4-fluoranyl-1~{H}-indol-3-yl)methyl]-2,3,6,7,8,8~{a}-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione, Cytochrome P450-F5053, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Ma, B.D, Tian, W, Qu, X, Kong, X.D. | 登録日 | 2022-12-09 | 公開日 | 2023-04-26 | 最終更新日 | 2023-07-12 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Engineering the Substrate Specificity of a P450 Dimerase Enables the Collective Biosynthesis of Heterodimeric Tryptophan-Containing Diketopiperazines. Angew.Chem.Int.Ed.Engl., 62, 2023
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8IS2
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8K2P
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8K2O
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7YRD
| histone methyltransferase | 分子名称: | DNA (146-MER), Histone H2A.Z, Histone H2B 1.1, ... | 著者 | Li, H, Wang, W.Y. | 登録日 | 2022-08-09 | 公開日 | 2023-08-16 | 最終更新日 | 2023-12-13 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural insight into H4K20 methylation on H2A.Z-nucleosome by SUV420H1. Mol.Cell, 83, 2023
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7YRG
| histone methyltransferase | 分子名称: | DNA (146-MER), Histone H2A.Z, Histone H2B 1.1, ... | 著者 | Li, H, Wang, W.Y. | 登録日 | 2022-08-09 | 公開日 | 2023-12-13 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Structural insight into H4K20 methylation on H2A.Z-nucleosome by SUV420H1. Mol.Cell, 83, 2023
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6LBS
| Crystal structure of yeast Stn1 | 分子名称: | KLLA0C11825p | 著者 | Ge, Y, Wu, Z, Wu, J, Lei, M. | 登録日 | 2019-11-14 | 公開日 | 2020-07-15 | 最終更新日 | 2020-08-19 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural insights into telomere protection and homeostasis regulation by yeast CST complex. Nat.Struct.Mol.Biol., 27, 2020
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6LBR
| Crystal structure of yeast Cdc13 and ssDNA | 分子名称: | KLLA0F20922p, Telomere single-strand DNA | 著者 | Ge, Y, Wu, Z, Wu, J, Lei, M. | 登録日 | 2019-11-14 | 公開日 | 2020-07-15 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural insights into telomere protection and homeostasis regulation by yeast CST complex. Nat.Struct.Mol.Biol., 27, 2020
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6LBU
| Crystal structure of yeast Stn1 and Ten1 | 分子名称: | KLLA0C11825p, KLLA0E09417p | 著者 | Ge, Y, Wu, Z, Wu, J, Lei, M. | 登録日 | 2019-11-14 | 公開日 | 2020-07-15 | 最終更新日 | 2020-08-19 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural insights into telomere protection and homeostasis regulation by yeast CST complex. Nat.Struct.Mol.Biol., 27, 2020
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