7LAA
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7LAB
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7LD1
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7LCN
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5YAX
| Crystal structure of a human neutralizing antibody bound to a HBV preS1 peptide | 分子名称: | Large envelope protein, SODIUM ION, scFv1 antibody | 著者 | Liu, X, Zheng, S, Ye, K, Sui, J. | 登録日 | 2017-09-02 | 公開日 | 2017-10-11 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | A potent human neutralizing antibody Fc-dependently reduces established HBV infections Elife, 6, 2017
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5IME
| Crystal structure of P21-activated kinase 1 (PAK1) in complex with compound 9 | 分子名称: | 8-(3-aminopropyl)-6-[2-chloro-4-(3-methyl-2-oxopyrazin-1(2H)-yl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one, Serine/threonine-protein kinase PAK 1 | 著者 | Li, D, Wang, W. | 登録日 | 2016-03-06 | 公開日 | 2016-05-25 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.217 Å) | 主引用文献 | Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window. J.Med.Chem., 59, 2016
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6IZ5
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5KIT
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6WPE
| HUMAN IDO1 IN COMPLEX WITH COMPOUND 4 | 分子名称: | 4-chloro-N-{[1-(3-chlorobenzene-1-carbonyl)-1,2,3,4-tetrahydroquinolin-6-yl]methyl}benzamide, Indoleamine 2,3-dioxygenase 1 | 著者 | Lesburg, C.A, Lammens, A. | 登録日 | 2020-04-27 | 公開日 | 2021-03-10 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | 主引用文献 | Carbamate and N -Pyrimidine Mitigate Amide Hydrolysis: Structure-Based Drug Design of Tetrahydroquinoline IDO1 Inhibitors. Acs Med.Chem.Lett., 12, 2021
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7RRB
| IDO1 IN COMPLEX WITH COMPOUND 9 | 分子名称: | 3-[4-(6-cyclopropylpyridin-3-yl)phenyl]-N-(4-fluorophenyl)oxetane-3-carboxamide, Indoleamine 2,3-dioxygenase 1 | 著者 | Lesburg, C.A. | 登録日 | 2021-08-09 | 公開日 | 2022-03-16 | 最終更新日 | 2022-05-11 | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | 主引用文献 | Oxetane Promise Delivered: Discovery of Long-Acting IDO1 Inhibitors Suitable for Q3W Oral or Parenteral Dosing. J.Med.Chem., 65, 2022
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7RRC
| IDO1 IN COMPLEX WITH COMPOUND 14 | 分子名称: | Indoleamine 2,3-dioxygenase 1, N-(4-fluorophenyl)-3-{4-[4-(hydroxymethyl)-6-(trifluoromethyl)pyridin-3-yl]phenyl}oxetane-3-carboxamide | 著者 | Lesburg, C.A. | 登録日 | 2021-08-09 | 公開日 | 2022-03-16 | 最終更新日 | 2022-05-11 | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | 主引用文献 | Oxetane Promise Delivered: Discovery of Long-Acting IDO1 Inhibitors Suitable for Q3W Oral or Parenteral Dosing. J.Med.Chem., 65, 2022
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7LJR
| SARS-CoV-2 Spike Protein Trimer bound to DH1043 fab | 分子名称: | Fab DH1043 heavy chain, Fab DH1043 light chain, Spike glycoprotein | 著者 | Gobeil, S, Acharya, P. | 登録日 | 2021-01-30 | 公開日 | 2021-03-31 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.66 Å) | 主引用文献 | The functions of SARS-CoV-2 neutralizing and infection-enhancing antibodies in vitro and in mice and nonhuman primates. Biorxiv, 2021
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4R0U
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4R0P
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4R0W
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8I2Q
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8I2R
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7BH8
| 3H4-Fab HLA-E-VL9 co-complex | 分子名称: | 3H4 Fab heavy chain, 3H4 Fab light chain, Beta-2-microglobulin, ... | 著者 | Walters, L.C, Rozbesky, D. | 登録日 | 2021-01-10 | 公開日 | 2022-04-13 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Mouse and human antibodies bind HLA-E-leader peptide complexes and enhance NK cell cytotoxicity. Commun Biol, 5, 2022
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3LGP
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7C8P
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4WBQ
| Crystal structure of the exonuclease domain of QIP (QDE-2 interacting protein) solved by native-SAD phasing. | 分子名称: | CALCIUM ION, QDE-2-interacting protein | 著者 | Boland, A, Weinert, T, Weichenrieder, O, Wang, M. | 登録日 | 2014-09-03 | 公開日 | 2014-12-10 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.693 Å) | 主引用文献 | Fast native-SAD phasing for routine macromolecular structure determination. Nat.Methods, 12, 2015
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4WBX
| Conserved hypothetical protein PF1771 from Pyrococcus furiosus solved by sulfur SAD using Swiss Light Source data | 分子名称: | 2-keto acid:ferredoxin oxidoreductase subunit alpha | 著者 | Weinert, T, Waltersperger, S, Olieric, V, Panepucci, E, Chen, L, Rose, J.P, Wang, M, Wang, B.C, Southeast Collaboratory for Structural Genomics (SECSG) | 登録日 | 2014-09-04 | 公開日 | 2014-12-10 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.301 Å) | 主引用文献 | Fast native-SAD phasing for routine macromolecular structure determination. Nat.Methods, 12, 2015
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4WAU
| Crystal structure of CENP-M solved by native-SAD phasing | 分子名称: | Centromere protein M | 著者 | Weinert, T, Basilico, F, Cecatiello, V, Pasqualato, S, Wang, M. | 登録日 | 2014-09-01 | 公開日 | 2014-12-10 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Fast native-SAD phasing for routine macromolecular structure determination. Nat.Methods, 12, 2015
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6WMW
| GFRAL receptor bound with two antibody Fabs (3P10, 25M22) | 分子名称: | FAB25M22 heavy chain fragment, FAB25M22 light chain, FAB3P10 heavy chain fragment, ... | 著者 | White, A, Lakshminarasimhan, D, Olland, A, Suto, R.K. | 登録日 | 2020-04-21 | 公開日 | 2020-07-15 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.91 Å) | 主引用文献 | Antibody-mediated inhibition of GDF15-GFRAL activity reverses cancer cachexia in mice. Nat Med, 26, 2020
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6CWA
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