7LAB

Structure of SARS-CoV-2 S protein in complex with N-terminal domain antibody DH1052

Summary for 7LAB

• Entry DOI: 10.2210/pdb7lab/pdb
• Related: 7LAA 7LAB 7LCN 7LD1
• EMDB information: 23246 23248
• Descriptor: DH1052 light chain, DH1052 heavy chain, Spike glycoprotein, ... (5 entities in total)
• Functional Keywords: rbd antibody, dh1052, sars, covid-19, sars-cov-2 2p s ectodomain, viral protein, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 9
• Total formula weight: 522526.78

Authors

Manne, K.,Acharya, P. (deposition date: 2021-01-06, release date: 2021-03-10, Last modification date: 2021-08-18)

• Primary citation: Li, D.,Edwards, R.J.,Manne, K.,Martinez, D.R.,Schafer, A.,Alam, S.M.,Wiehe, K.,Lu, X.,Parks, R.,Sutherland, L.L.,Oguin 3rd, T.H.,McDanal, C.,Perez, L.G.,Mansouri, K.,Gobeil, S.M.C.,Janowska, K.,Stalls, V.,Kopp, M.,Cai, F.,Lee, E.,Foulger, A.,Hernandez, G.E.,Sanzone, A.,Tilahun, K.,Jiang, C.,Tse, L.V.,Bock, K.W.,Minai, M.,Nagata, B.M.,Cronin, K.,Gee-Lai, V.,Deyton, M.,Barr, M.,Von Holle, T.,Macintyre, A.N.,Stover, E.,Feldman, J.,Hauser, B.M.,Caradonna, T.M.,Scobey, T.D.,Rountree, W.,Wang, Y.,Moody, M.A.,Cain, D.W.,DeMarco, C.T.,Denny, T.N.,Woods, C.W.,Petzold, E.W.,Schmidt, A.G.,Teng, I.T.,Zhou, T.,Kwong, P.D.,Mascola, J.R.,Graham, B.S.,Moore, I.N.,Seder, R.,Andersen, H.,Lewis, M.G.,Montefiori, D.C.,Sempowski, G.D.,Baric, R.S.,Acharya, P.,Haynes, B.F.,Saunders, K.O.; In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies.; Cell, 184:4203-, 2021; PubMed: 34242577; DOI: 10.1016/j.cell.2021.06.021

Experimental method

ELECTRON MICROSCOPY (2.97 Å)