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6AG2
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BU of 6ag2 by Molmil
uPA-HMA
Descriptor: 3,5-bis(azanyl)-N-carbamimidoyl-6-(2-methoxypyrimidin-5-yl)pyrazine-2-carboxamide, SULFATE ION, Urokinase-type plasminogen activator
Authors:Buckley, B, Jiang, L.G, Huang, M.D, Kelso, M, Ranson, M.
Deposit date:2018-08-09
Release date:2019-09-18
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:uPA-HMA
To Be Published
7DZD
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BU of 7dzd by Molmil
Crystal structure of uPA in complex with cleaved camostat
Descriptor: 4-carbamimidamidobenzoic acid, TRIETHYLENE GLYCOL, Urokinase-type plasminogen activator
Authors:Jiang, L.G, Huang, M.D.
Deposit date:2021-01-25
Release date:2021-07-14
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of uPA in complex with cleaved camostat
To Be Published
3U74
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BU of 3u74 by Molmil
Crystal structure of stabilized human uPAR mutant
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Urokinase plasminogen activator surface receptor
Authors:Huang, M.D, Xu, X, Yuan, C.
Deposit date:2011-10-13
Release date:2012-04-18
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Crystal structure of the urokinase receptor in a ligand-free form.
J.Mol.Biol., 416, 2012
3U73
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BU of 3u73 by Molmil
Crystal structure of stabilized human uPAR mutant in complex with ATF
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Urokinase plasminogen activator surface receptor, Urokinase-type plasminogen activator, ...
Authors:Huang, M.D, Xu, X, Yuan, C.
Deposit date:2011-10-13
Release date:2012-04-18
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.19 Å)
Cite:Crystal structure of the urokinase receptor in a ligand-free form.
J.Mol.Biol., 416, 2012
4ISO
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BU of 4iso by Molmil
Crystal Structure of Matriptase in complex with its inhibitor HAI-1
Descriptor: DI(HYDROXYETHYL)ETHER, GLUTATHIONE, GLYCEROL, ...
Authors:Huang, M.D, Zhao, B.Y, Yuan, C, Li, R.
Deposit date:2013-01-16
Release date:2013-03-06
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Crystal structures of matriptase in complex with its inhibitor hepatocyte growth factor activator inhibitor-1.
J.Biol.Chem., 288, 2013
4ISN
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BU of 4isn by Molmil
Crystal Structure of Matriptase in complex with its inhibitor HAI-1
Descriptor: GLUTATHIONE, Kunitz-type protease inhibitor 1, Suppressor of tumorigenicity 14 protein, ...
Authors:Huang, M.D, Zhao, B.Y, Yuan, C, Li, R.
Deposit date:2013-01-16
Release date:2013-03-06
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal structures of matriptase in complex with its inhibitor hepatocyte growth factor activator inhibitor-1.
J.Biol.Chem., 288, 2013
4IS5
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BU of 4is5 by Molmil
Crystal Structure of the ligand-free inactive Matriptase
Descriptor: GLUTATHIONE, GLYCEROL, SULFATE ION, ...
Authors:Huang, M.D, Zhao, B.Y, Yuan, C, Li, R.
Deposit date:2013-01-16
Release date:2013-03-06
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Crystal structures of matriptase in complex with its inhibitor hepatocyte growth factor activator inhibitor-1.
J.Biol.Chem., 288, 2013
4ISL
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BU of 4isl by Molmil
Crystal Structure of the inactive Matriptase in complex with its inhibitor HAI-1
Descriptor: GLUTATHIONE, GLYCEROL, Kunitz-type protease inhibitor 1, ...
Authors:Huang, M.D, Zhao, B.Y, Yuan, C, Li, R.
Deposit date:2013-01-16
Release date:2013-03-06
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Crystal structures of matriptase in complex with its inhibitor hepatocyte growth factor activator inhibitor-1.
J.Biol.Chem., 288, 2013
4K24
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BU of 4k24 by Molmil
Structure of anti-uPAR Fab ATN-658 in complex with uPAR
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Urokinase plasminogen activator surface receptor, ...
Authors:Huang, M.D, Xu, X, Yuan, C.
Deposit date:2013-04-08
Release date:2014-02-26
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (4.5 Å)
Cite:Identification of a New Epitope in uPAR as a Target for the Cancer Therapeutic Monoclonal Antibody ATN-658, a Structural Homolog of the uPAR Binding Integrin CD11b ( alpha M)
Plos One, 9, 2014
6XVD
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BU of 6xvd by Molmil
Crystal structure of complex of urokinase and a upain-1 variant(W3F) in pH7.4 condition
Descriptor: Urokinase-type plasminogen activator, upain-1-W3F
Authors:Xue, G.P, Xie, X, Zhou, Y, Yuan, C, Huang, M.D, Jiang, L.G.
Deposit date:2020-01-21
Release date:2020-02-19
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Insight to the residue in P2 position prevents the peptide inhibitor from being hydrolyzed by serine proteases.
Biosci.Biotechnol.Biochem., 84, 2020
8ITT
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BU of 8itt by Molmil
Crystal structure of lysophosphatidylcholine in complex with human serum albumin and myristate
Descriptor: Albumin, MYRISTIC ACID, [1-MYRISTOYL-GLYCEROL-3-YL]PHOSPHONYLCHOLINE
Authors:Wang, Y, Jiang, L.G, Huang, M.D.
Deposit date:2023-03-22
Release date:2024-01-31
Method:X-RAY DIFFRACTION (3.03 Å)
Cite:Crystal structures of human serum albumin in complex with lysophosphatidylcholine.
Biophys.J., 122, 2023
8ITR
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BU of 8itr by Molmil
Crystal structure of lysophosphatidylcholine in complex with human serum albumin
Descriptor: Albumin, [1-MYRISTOYL-GLYCEROL-3-YL]PHOSPHONYLCHOLINE
Authors:Wang, Y, Jiang, L.G, Huang, M.D.
Deposit date:2023-03-22
Release date:2024-01-31
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Crystal structures of human serum albumin in complex with lysophosphatidylcholine.
Biophys.J., 122, 2023
6ITE
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BU of 6ite by Molmil
Crystal structure of group A Streptococcal surface dehydrogenase (SDH)
Descriptor: Glyceraldehyde-3-phosphate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SULFATE ION
Authors:Yuan, C, Li, R, Huang, M.D.
Deposit date:2018-11-21
Release date:2019-09-25
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.739 Å)
Cite:Structural determination of group A Streptococcal surface dehydrogenase and characterization of its interaction with urokinase-type plasminogen activator receptor.
Biochem.Biophys.Res.Commun., 510, 2019
5ZAJ
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BU of 5zaj by Molmil
uPA-31F
Descriptor: 3-azanyl-5-(azepan-1-yl)-N-carbamimidoyl-6-(2,4-dimethoxypyrimidin-5-yl)pyrazine-2-carboxamide, Urokinase-type plasminogen activator chain B
Authors:Buckley, B.J, Jiang, L.G, Huang, M.D, Kelso, M.J, Ranson, M.
Deposit date:2018-02-07
Release date:2018-12-19
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer.
J. Med. Chem., 61, 2018
5ZAG
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BU of 5zag by Molmil
uPA-BB2-94F
Descriptor: 3-azanyl-5-(azepan-1-yl)-N-carbamimidoyl-6-pyrimidin-5-yl-pyrazine-2-carboxamide, Urokinase-type plasminogen activator chain B
Authors:Buckley, B.J, Jiang, L.G, Huang, M.D, Kelso, M.J, Ranson, M.
Deposit date:2018-02-07
Release date:2018-12-19
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer.
J. Med. Chem., 61, 2018
5ZA8
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BU of 5za8 by Molmil
uPA-BB2-27F
Descriptor: 3-azanyl-5-(azepan-1-yl)-N-carbamimidoyl-6-(1-methylpyrazol-4-yl)pyrazine-2-carboxamide, Urokinase-type plasminogen activator chain B
Authors:Buckley, B.J, Jiang, L.G, Huang, M.D, Kelso, M.J, Ranson, M.
Deposit date:2018-02-06
Release date:2018-12-19
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer.
J. Med. Chem., 61, 2018
5ZAF
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BU of 5zaf by Molmil
uPA-BB2-28F
Descriptor: 3-azanyl-5-(azepan-1-yl)-N-carbamimidoyl-6-(furan-3-yl)pyrazine-2-carboxamide, Urokinase-type plasminogen activator chain B
Authors:Buckley, B.J, Jiang, L.G, Huang, M.D, Kelso, M.J, Ranson, M.
Deposit date:2018-02-07
Release date:2018-12-19
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer.
J. Med. Chem., 61, 2018
5ZA7
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BU of 5za7 by Molmil
uPA-HMA
Descriptor: 3-azanyl-5-(azepan-1-yl)-N-[bis(azanyl)methylidene]-6-chloranyl-pyrazine-2-carboxamide, SULFATE ION, Urokinase-type plasminogen activator chain B
Authors:Buckley, B.J, Jiang, L.G, Huang, M.D, Kelso, M.J, Ranson, M.
Deposit date:2018-02-06
Release date:2018-12-19
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer.
J. Med. Chem., 61, 2018
5ZAE
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BU of 5zae by Molmil
uPA-6F-HMA
Descriptor: 3-azanyl-5-(azepan-1-yl)-N-carbamimidoyl-6-(furan-2-yl)pyrazine-2-carboxamide, SULFATE ION, Urokinase-type plasminogen activator chain B
Authors:Buckley, B.J, Jiang, L.G, Huang, M.D, Kelso, M.J, Ranson, M.
Deposit date:2018-02-07
Release date:2018-12-19
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer.
J. Med. Chem., 61, 2018
5ZC5
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BU of 5zc5 by Molmil
uPA-NU-09F
Descriptor: 3-azanyl-5-(azepan-1-yl)-N-carbamimidoyl-6-(4-fluoranyl-1-benzofuran-2-yl)pyrazine-2-carboxamide, Urokinase-type plasminogen activator chain B
Authors:Jiang, L.G, Buckley, B.J, Huang, M.D, Kelso, M.J, Ranson, M.
Deposit date:2018-02-15
Release date:2018-12-19
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer.
J. Med. Chem., 61, 2018
5ZAH
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BU of 5zah by Molmil
uPA-BB2-30F
Descriptor: 3-azanyl-5-(azepan-1-yl)-N-carbamimidoyl-6-(2-methoxypyrimidin-5-yl)pyrazine-2-carboxamide, Urokinase-type plasminogen activator chain B
Authors:Buckley, B.J, Jiang, L.G, Huang, M.D, Kelso, M.J, Ranson, M.
Deposit date:2018-02-07
Release date:2018-12-19
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.98 Å)
Cite:6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer.
J. Med. Chem., 61, 2018
5ZA9
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BU of 5za9 by Molmil
uPA-BB2-50F
Descriptor: 3-azanyl-5-(azepan-1-yl)-6-(1-benzofuran-2-yl)-Ncarbamimidoyl-pyrazine-2-carboxamide, Urokinase-type plasminogen activator chain B
Authors:Buckley, B.J, Jiang, L.G, Huang, M.D, Kelso, M.J, Ranson, M.
Deposit date:2018-02-07
Release date:2018-12-19
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer.
J. Med. Chem., 61, 2018
6A8G
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BU of 6a8g by Molmil
The crystal structure of muPAin-1-IG in complex with muPA-SPD at pH8.5
Descriptor: PHOSPHATE ION, Urokinase-type plasminogen activator chain B, muPAin-1-IG
Authors:Wang, D, Yang, Y.S, Jiang, L.G, Huang, M.D, Li, J.Y, Andreasen, P.A, Xu, P, Chen, Z.
Deposit date:2018-07-08
Release date:2019-02-20
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Suppression of Tumor Growth and Metastases by Targeted Intervention in Urokinase Activity with Cyclic Peptides.
J.Med.Chem., 62, 2019
6A8N
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BU of 6a8n by Molmil
The crystal structure of muPAin-1-IG-2 in complex with muPA-SPD at pH8.5
Descriptor: CYS-PRO-ALA-TYR-SER-ARG-TYR-ILE-GLY-CYS, Urokinase-type plasminogen activator B
Authors:Wang, D, Yang, Y.S, Jiang, L.G, Huang, M.D, Li, J.Y, Andreasen, P.A, Xu, P, Chen, Z.
Deposit date:2018-07-09
Release date:2019-02-20
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.489 Å)
Cite:Suppression of Tumor Growth and Metastases by Targeted Intervention in Urokinase Activity with Cyclic Peptides.
J.Med.Chem., 62, 2019
7VM5
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BU of 7vm5 by Molmil
Crystal structure of uPA in complex with 4-guanidinobenzoic acid
Descriptor: 4-carbamimidamidobenzoic acid, TRIETHYLENE GLYCOL, Urokinase-type plasminogen activator
Authors:Jiang, L.G, Huang, M.D.
Deposit date:2021-10-07
Release date:2022-10-12
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Structural study of the uPA-nafamostat complex reveals a covalent inhibitory mechanism of nafamostat.
Biophys.J., 121, 2022

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