4KSP
| Crystal Structure of Human B-raf bound to a DFG-out Inhibitor TAK-632 | Descriptor: | N-{7-cyano-6-[4-fluoro-3-({[3-(trifluoromethyl)phenyl]acetyl}amino)phenoxy]-1,3-benzothiazol-2-yl}cyclopropanecarboxamide, Serine/threonine-protein kinase B-raf | Authors: | Yano, J.K, Masanori, O. | Deposit date: | 2013-05-17 | Release date: | 2013-07-24 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.93 Å) | Cite: | Discovery of a Selective Kinase Inhibitor (TAK-632) Targeting Pan-RAF Inhibition: Design, Synthesis, and Biological Evaluation of C-7-Substituted 1,3-Benzothiazole Derivatives. J.Med.Chem., 56, 2013
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4KSQ
| Crystal Structure of Human B-raf bound to a DFG-out Inhibitor 5B | Descriptor: | N-{7-cyano-6-[4-fluoro-3-({[3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-1,3-benzothiazol-2-yl}cyclopropanecarboxamide, Serine/threonine-protein kinase B-raf | Authors: | Yano, J.K, Masanori, O. | Deposit date: | 2013-05-17 | Release date: | 2013-07-24 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Discovery of a Selective Kinase Inhibitor (TAK-632) Targeting Pan-RAF Inhibition: Design, Synthesis, and Biological Evaluation of C-7-Substituted 1,3-Benzothiazole Derivatives. J.Med.Chem., 56, 2013
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2YZ1
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5AVD
| The 0.86 angstrom structure of elastase crystallized in high-strength agarose hydrogel | Descriptor: | Chymotrypsin-like elastase family member 1, SULFATE ION | Authors: | Sugiyama, S, Shimizu, N, Maruyama, M, Sazaki, G, Adachi, H, Takano, K, Murakami, S, Inoue, T, Mori, Y, Matsumura, H. | Deposit date: | 2015-06-15 | Release date: | 2015-07-08 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (0.86 Å) | Cite: | Growth of protein crystals in hydrogels prevents osmotic shock J.Am.Chem.Soc., 134, 2012
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7W6Y
| Crystal structure of Kangiella koreensis RseP orthologue in complex with batimastat in space group P1 | Descriptor: | 4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE, Anti sigma-E protein, RseA, ... | Authors: | Imaizumi, Y, Takanuki, K, Nogi, T. | Deposit date: | 2021-12-02 | Release date: | 2022-09-07 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Mechanistic insights into intramembrane proteolysis by E. coli site-2 protease homolog RseP. Sci Adv, 8, 2022
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7W6X
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7W6Z
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7W70
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5AVH
| The 0.90 angstrom structure (I222) of glucose isomerase crystallized in high-strength agarose hydrogel | Descriptor: | Xylose isomerase | Authors: | Sugiyama, S, Shimizu, N, Maruyama, N, Sazaki, G, Adachi, H, Takano, K, Murakami, S, Inoue, T, Mori, Y, Matsumura, H. | Deposit date: | 2015-06-16 | Release date: | 2015-07-08 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (0.9 Å) | Cite: | Growth of protein crystals in hydrogels prevents osmotic shock J.Am.Chem.Soc., 134, 2012
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5AVN
| The 1.03 angstrom structure (P212121) of glucose isomerase crystallized in high-strength agarose hydrogel | Descriptor: | CALCIUM ION, MANGANESE (II) ION, SULFATE ION, ... | Authors: | Sugiyama, S, Shimizu, N, Maruyama, N, Sazaki, G, Adachi, H, Takano, K, Murakami, S, Inoue, T, Mori, Y, Matsumura, H. | Deposit date: | 2015-06-23 | Release date: | 2015-07-08 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.03 Å) | Cite: | Growth of protein crystals in hydrogels prevents osmotic shock J.Am.Chem.Soc., 134, 2012
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7CQD
| The NZ-1 Fab complexed with the PDZ tandem fragment of A. aeolicus S2P homolog with the PA14 tag inserted between the residues 235 and 236 | Descriptor: | Heavy chain of antigen binding fragment, Fab of NZ-1, Light chain of antigen binding fragment, ... | Authors: | Tamura-Sakaguchi, R, Aruga, R, Nogi, T. | Deposit date: | 2020-08-10 | Release date: | 2021-05-19 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Moving toward generalizable NZ-1 labeling for 3D structure determination with optimized epitope-tag insertion. Acta Crystallogr D Struct Biol, 77, 2021
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7CQC
| The NZ-1 Fab complexed with the PDZ tandem fragment of A. aeolicus S2P homolog with the PA14 tag inserted between the residues 181 and 184 | Descriptor: | Heavy chain of antigen binding fragment, Fab of NZ-1, Light chain of antigen binding fragment, ... | Authors: | Aruga, R, Tamura-Sakaguchi, R, Nogi, T. | Deposit date: | 2020-08-10 | Release date: | 2021-05-19 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Moving toward generalizable NZ-1 labeling for 3D structure determination with optimized epitope-tag insertion. Acta Crystallogr D Struct Biol, 77, 2021
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7VG7
| Plexin B1 extracellular fragment in complex with lasso-grafted PB1m6A9 peptide | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Plexin-B1, TRIETHYLENE GLYCOL, ... | Authors: | Sugano, N.N, Hirata, K, Yamashita, K, Yamamoto, M, Arimori, T, Takagi, J. | Deposit date: | 2021-09-14 | Release date: | 2022-08-17 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | De novo Fc-based receptor dimerizers differentially modulate PlexinB1 function. Structure, 30, 2022
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7VF3
| Plexin B1 extracellular fragment in complex with lasso-grafted PB1m7 peptide | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, DI(HYDROXYETHYL)ETHER, Plexin-B1, ... | Authors: | Sugano, N.N, Hirata, K, Yamashita, K, Yamamoto, M, Arimori, T, Takagi, J. | Deposit date: | 2021-09-10 | Release date: | 2022-08-17 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.29 Å) | Cite: | De novo Fc-based receptor dimerizers differentially modulate PlexinB1 function. Structure, 30, 2022
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1NNT
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7WU9
| Cryo-EM structure of the human EP3-Gi signaling complex | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Suno, R, Sugita, Y, Morimoto, K, Iwasaki, K, Kato, T, Kobayashi, T. | Deposit date: | 2022-02-07 | Release date: | 2022-08-17 | Last modified: | 2023-10-04 | Method: | ELECTRON MICROSCOPY (3.375 Å) | Cite: | Structural insights into the G protein selectivity revealed by the human EP3-G i signaling complex. Cell Rep, 40, 2022
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3VNT
| Crystal Structure of the Kinase domain of Human VEGFR2 with a [1,3]thiazolo[5,4-b]pyridine derivative | Descriptor: | 1,2-ETHANEDIOL, 2-chloro-3-(1-cyanocyclopropyl)-N-[5-({2-[(cyclopropylcarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}oxy)-2-fluorophenyl]benzamide, Vascular endothelial growth factor receptor 2 | Authors: | Oki, H. | Deposit date: | 2012-01-17 | Release date: | 2012-04-11 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors. 1. Exploration of [5,6]-fused bicyclic scaffolds J.Med.Chem., 55, 2012
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7EVG
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7EVB
| Odinarchaeota tubulin (OdinTubulin) H393D mutant, in a protofilament arrangement, bound to 77% GTP/23% and 2 Na+ | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, SODIUM ION, ... | Authors: | Robinson, R.C, Akil, C. | Deposit date: | 2021-05-21 | Release date: | 2022-03-23 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.62 Å) | Cite: | Structure and dynamics of Odinarchaeota tubulin and the implications for eukaryotic microtubule evolution. Sci Adv, 8, 2022
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7EVE
| Odinarchaeota tubulin (OdinTubulin) H393D mutant, in a protofilament arrangement, bound to 100% GDP and 2 Na+ | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, SODIUM ION, Tubulin-like protein | Authors: | Robinson, R.C, Akil, C, Tran, L.T. | Deposit date: | 2021-05-21 | Release date: | 2022-03-23 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure and dynamics of Odinarchaeota tubulin and the implications for eukaryotic microtubule evolution. Sci Adv, 8, 2022
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7EVK
| Odinarchaeota tubulin (OdinTubulin) H393D mutant, in a protofilament arrangement, bound to 78% GTP, 22% GDP, Na+ | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, SODIUM ION, ... | Authors: | Robinson, R.C, Akil, C, Tran, L.T. | Deposit date: | 2021-05-21 | Release date: | 2022-03-23 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structure and dynamics of Odinarchaeota tubulin and the implications for eukaryotic microtubule evolution. Sci Adv, 8, 2022
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7F1A
| Odinarchaeota tubulin (OdinTubulin) H393D mutant, in a protofilament arrangement, bound 78% GTP/22% GDP 1 K+, 1 Mg2+ | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Robinson, R.C, Akil, C, Tran, L.T. | Deposit date: | 2021-06-08 | Release date: | 2022-03-23 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure and dynamics of Odinarchaeota tubulin and the implications for eukaryotic microtubule evolution. Sci Adv, 8, 2022
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7EVL
| Odinarchaeota tubulin (OdinTubulin) H393D mutant, in a protofilament arrangement, bound to 64% GTP/36% GDP and 2 Na+ in a small unit cell | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, SODIUM ION, ... | Authors: | Robinson, R.C, Akil, C, Tran, L.T. | Deposit date: | 2021-05-21 | Release date: | 2022-03-23 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Structure and dynamics of Odinarchaeota tubulin and the implications for eukaryotic microtubule evolution. Sci Adv, 8, 2022
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7EVC
| Odinarchaeota tubulin (OdinTubulin) H393D mutant, in a protofilament arrangement, bound to 60% GTP/40% GDP and 2 Na+ | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, SODIUM ION, ... | Authors: | Robinson, R.C, Akil, C, Tran, L.T. | Deposit date: | 2021-05-21 | Release date: | 2022-03-23 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Structure and dynamics of Odinarchaeota tubulin and the implications for eukaryotic microtubule evolution. Sci Adv, 8, 2022
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7EVH
| Odinarchaeota tubulin H393D mutant, in a psuedo protofilament arrangement, bound to 59% GDP, 41% phosphate | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, PHOSPHATE ION, Tubulin-like protein | Authors: | Robinson, R.C, Akil, C, Tran, L.T. | Deposit date: | 2021-05-21 | Release date: | 2022-03-23 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure and dynamics of Odinarchaeota tubulin and the implications for eukaryotic microtubule evolution. Sci Adv, 8, 2022
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