2CKB
| STRUCTURE OF THE 2C/KB/DEV8 COMPLEX | Descriptor: | ALPHA, BETA T CELL RECEPTOR, BETA-2 MICROGLOBULIN, ... | Authors: | Garcia, K.C, Degano, M, Wilson, I.A. | Deposit date: | 1998-01-14 | Release date: | 1998-04-29 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen. Science, 279, 1998
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1TCR
| MURINE T-CELL ANTIGEN RECEPTOR 2C CLONE | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Garcia, K.C, Degano, M, Stanfield, R.L, Wilson, I.A. | Deposit date: | 1996-09-12 | Release date: | 1997-03-12 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | An alphabeta T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex. Science, 274, 1996
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2E7L
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5UK5
| Complex of Notch1(EGF8-12) bound to Jagged1(N-EGF3) | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Garcia, K.C, Luca, V.C. | Deposit date: | 2017-01-19 | Release date: | 2017-03-08 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.506 Å) | Cite: | Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity. Science, 355, 2017
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3BPN
| Crystal structure of the IL4-IL4R-IL13Ra ternary complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-13 receptor alpha-1 chain, Interleukin-4, ... | Authors: | Garcia, K.C. | Deposit date: | 2007-12-18 | Release date: | 2008-02-05 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (3.02 Å) | Cite: | Molecular and Structural Basis of Cytokine Receptor Pleiotropy in the Interleukin-4/13 System. Cell(Cambridge,Mass.), 132, 2008
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3BPL
| Crystal structure of the IL4-IL4R-Common Gamma ternary complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Garcia, K.C. | Deposit date: | 2007-12-18 | Release date: | 2008-02-05 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (2.93 Å) | Cite: | Molecular and Structural Basis of Cytokine Receptor Pleiotropy in the Interleukin-4/13 System. Cell(Cambridge,Mass.), 132, 2008
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3BPO
| Crystal structure of the IL13-IL4R-IL13Ra ternary complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin 13, ... | Authors: | Garcia, K.C. | Deposit date: | 2007-12-18 | Release date: | 2008-02-05 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Molecular and Structural Basis of Cytokine Receptor Pleiotropy in the Interleukin-4/13 System. Cell(Cambridge,Mass.), 132, 2008
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2NYK
| Crystal structure of m157 from mouse cytomegalovirus | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, M157 | Authors: | Garcia, K.C. | Deposit date: | 2006-11-20 | Release date: | 2007-05-29 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural elucidation of the m157 mouse cytomegalovirus ligand for Ly49 natural killer cell receptors. Proc.Natl.Acad.Sci.Usa, 104, 2007
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2OI9
| Structure of the 2C/Ld/QL9 allogeneic complex | Descriptor: | Major Histocompatibility Complex protein, T cell receptor alpha chain, T cell receptor beta chain, ... | Authors: | Garcia, K.C, Colf, L.A. | Deposit date: | 2007-01-10 | Release date: | 2007-04-24 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | How a single T cell receptor recognizes both self and foreign MHC. Cell(Cambridge,Mass.), 129, 2007
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7N2P
| AS4.3-RNASEH2b-HLA*B27 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, AS4.3 T cell receptor alpha chain, AS4.3 T cell receptor beta chain, ... | Authors: | Yang, X, Jude, K.M, Garcia, K.C. | Deposit date: | 2021-05-29 | Release date: | 2022-12-07 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides. Nature, 612, 2022
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1JDN
| Crystal Structure of Hormone Receptor | Descriptor: | ATRIAL NATRIURETIC PEPTIDE CLEARANCE RECEPTOR, CHLORIDE ION, beta-D-mannopyranose-(1-4)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | He, X.-L, Chow, D.-C, Martick, M.M, Garcia, K.C. | Deposit date: | 2001-06-14 | Release date: | 2001-09-05 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Allosteric activation of a spring-loaded natriuretic peptide receptor dimer by hormone. Science, 293, 2001
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1SG1
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1G6R
| A FUNCTIONAL HOT SPOT FOR ANTIGEN RECOGNITION IN A SUPERAGONIST TCR/MHC COMPLEX | Descriptor: | ALPHA T CELL RECEPTOR, BETA T CELL RECEPTOR, BETA-2 MICROGLOBULIN, ... | Authors: | Degano, M, Garcia, K.C, Apostolopoulos, V, Rudolph, M.G, Teyton, L, Wilson, I.A. | Deposit date: | 2000-11-07 | Release date: | 2000-11-15 | Last modified: | 2018-01-31 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | A functional hot spot for antigen recognition in a superagonist TCR/MHC complex. Immunity, 12, 2000
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1GNA
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1GNB
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2RKC
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1XFD
| Structure of a human A-type Potassium Channel Accelerating factor DPPX, a member of the dipeptidyl aminopeptidase family | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Dipeptidyl aminopeptidase-like protein 6, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Strop, P, Bankovich, A.J, Hansen, K.C, Garcia, K.C, Brunger, A.T. | Deposit date: | 2004-09-14 | Release date: | 2004-10-26 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structure of a human A-type potassium channel interacting protein DPPX, a member of the dipeptidyl aminopeptidase family J.Mol.Biol., 343, 2004
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1U3H
| Crystal structure of mouse TCR 172.10 complexed with MHC class II I-Au molecule at 2.4 A | Descriptor: | H-2 class II histocompatibility antigen, A-U alpha chain, A-U beta chain, ... | Authors: | Maynard, J, Petersson, K, Wilson, D.H, Adams, E.J, Blondelle, S.E, Boulanger, M.J, Wilson, D.B, Garcia, K.C. | Deposit date: | 2004-07-21 | Release date: | 2005-05-17 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.42 Å) | Cite: | Structure of an autoimmune T cell receptor complexed with class II peptide-MHC: insights into MHC bias and antigen specificity Immunity, 22, 2005
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4KJY
| Complex of high-affinity SIRP alpha variant FD6 with CD47 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, High-affinity SIRPa variant FD6, Leukocyte surface antigen CD47, ... | Authors: | Ring, A.M, Ozkan, E, Ho, C.C.M, Garcia, K.C. | Deposit date: | 2013-05-04 | Release date: | 2013-06-12 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Engineered SIRP alpha variants as immunotherapeutic adjuvants to anticancer antibodies. Science, 341, 2013
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8VSP
| Cryo-EM structure of human invariant chain in complex with HLA-DQ | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, HLA class II histocompatibility antigen gamma chain, HLA class II histocompatibility antigen, ... | Authors: | Wang, N, Caveney, N.A, Jude, K.M, Garcia, K.C. | Deposit date: | 2024-01-24 | Release date: | 2024-05-08 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.12 Å) | Cite: | Structural insights into human MHC-II association with invariant chain. Proc.Natl.Acad.Sci.USA, 121, 2024
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8VRW
| Cryo-EM structure of human invariant chain in complex with HLA-DR15 | Descriptor: | HLA class II histocompatibility antigen gamma chain, HLA class II histocompatibility antigen, DR alpha chain, ... | Authors: | Wang, N, Caveney, N.A, Jude, K.M, Garcia, K.C. | Deposit date: | 2024-01-22 | Release date: | 2024-05-08 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.03 Å) | Cite: | Structural insights into human MHC-II association with invariant chain. Proc.Natl.Acad.Sci.USA, 121, 2024
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8VSJ
| Engineered peptide-specific binder in complex with HLA-DR1/CLIP | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Class-II-associated invariant chain peptide, HLA class II histocompatibility antigen DR beta chain, ... | Authors: | Jude, K.M, Yang, X, Du, H, Kassardjian, A, Julien, J.-P, Huang, P, Garcia, K.C. | Deposit date: | 2024-01-24 | Release date: | 2024-10-02 | Method: | ELECTRON MICROSCOPY (2.28 Å) | Cite: | Differentiating MHC-II antigens with a single loop To Be Published
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6NE1
| Designed repeat protein in complex with Fz4 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Frizzled-4, Pfs, ... | Authors: | Miao, Y, Jude, K.M, Garcia, K.C. | Deposit date: | 2018-12-15 | Release date: | 2019-05-15 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.011 Å) | Cite: | Receptor subtype discrimination using extensive shape complementary designed interfaces. Nat.Struct.Mol.Biol., 26, 2019
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6NE4
| Designed repeat protein specifically in complex with Fz7CRD | Descriptor: | 1,2-ETHANEDIOL, Designed repeat binding protein, Frizzled-7, ... | Authors: | Miao, Y, Jude, K.M, Garcia, K.C. | Deposit date: | 2018-12-16 | Release date: | 2019-05-15 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (1.648 Å) | Cite: | Receptor subtype discrimination using extensive shape complementary designed interfaces. Nat.Struct.Mol.Biol., 26, 2019
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5T5W
| Structure of an affinity matured lambda-IFN/IFN-lambdaR1/IL-10Rbeta receptor complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interferon lambda receptor 1, Interferon lambda-3, ... | Authors: | Mendoza, J.L, Jude, K.M, Garcia, K.C. | Deposit date: | 2016-08-31 | Release date: | 2017-03-29 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.847 Å) | Cite: | The IFN-lambda-IFN-lambda R1-IL-10R beta Complex Reveals Structural Features Underlying Type III IFN Functional Plasticity. Immunity, 46, 2017
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