2R59
 
 | | Leukotriene A4 hydrolase complexed with inhibitor RB3041 | | 分子名称: | ACETIC ACID, Leukotriene A-4 hydrolase, N-{(2S)-3-[(R)-[(1R)-1-amino-2-phenylethyl](hydroxy)phosphoryl]-2-benzylpropanoyl}-L-phenylalanine, ... | | 著者 | Tholander, F, Haeggstrom, J.Z, Thunnissen, M, Muroya, A, Roques, B.P, Fournie-Zaluski, M.C. | | 登録日 | 2007-09-03 | | 公開日 | 2008-08-12 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | | 主引用文献 | Structure-based dissection of the active site chemistry of leukotriene a4 hydrolase: implications for m1 aminopeptidases and inhibitor design.
Chem.Biol., 15, 2008
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1BJ6
 | | 1H NMR OF (12-53) NCP7/D(ACGCC) COMPLEX, 10 STRUCTURES | | 分子名称: | DNA (5'-D(*AP*CP*GP*CP*C)-3'), NUCLEOCAPSID PROTEIN 7, ZINC ION | | 著者 | Demene, H, Morellet, N, Teilleux, V, Huynh-Dinh, T, De Rocquigny, H, Fournie-Zaluski, M.C, Roques, B.P. | | 登録日 | 1998-07-03 | | 公開日 | 1999-02-02 | | 最終更新日 | 2022-02-16 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure of the complex between the HIV-1 nucleocapsid protein NCp7 and the single-stranded pentanucleotide d(ACGCC).
J.Mol.Biol., 283, 1998
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1Z9G
 | | Crystal Structure Analysis of Thermolysin Complexed with the Inhibitor (R)-retro-thiorphan | | 分子名称: | (R)-RETRO-THIORPHAN, CALCIUM ION, Thermolysin, ... | | 著者 | Roderick, S.L, Fournie-Zaluski, M.C, Roques, B.P, Matthews, B.W. | | 登録日 | 2005-04-01 | | 公開日 | 2005-04-19 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Thiorphan and retro-thiorphan display equivalent interactions when bound to crystalline thermolysin
Biochemistry, 28, 1989
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1ZDP
 | | Crystal Structure Analysis of Thermolysin Complexed with the Inhibitor (S)-thiorphan | | 分子名称: | (2-MERCAPTOMETHYL-3-PHENYL-PROPIONYL)-GLYCINE, CALCIUM ION, Thermolysin, ... | | 著者 | Roderick, S.L, Fournie-Zaluski, M.C, Roques, B.P, Matthews, B.W. | | 登録日 | 2005-04-14 | | 公開日 | 2005-04-26 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Thiorphan and retro-thiorphan display equivalent interactions when bound to crystalline thermolysin
Biochemistry, 28, 1989
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1QF0
 | | THERMOLYSIN (E.C.3.4.24.27) COMPLEXED WITH (2-SULPHANYL-3-PHENYLPROPANOYL)-PHE-TYR. PARAMETERS FOR ZN-BIDENTATION OF MERCAPTOACYLDIPEPTIDES IN METALLOENDOPEPTIDASE | | 分子名称: | (2-SULFANYL-3-PHENYLPROPANOYL)-PHE-TYR, CALCIUM ION, DIMETHYL SULFOXIDE, ... | | 著者 | Gaucher, J.-F, Selkti, M, Tiraboschi, G, Prange, T, Roques, B.P, Tomas, A, Fournie-Zaluski, M.C. | | 登録日 | 1999-04-06 | | 公開日 | 1999-12-29 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal structures of alpha-mercaptoacyldipeptides in the thermolysin active site: structural parameters for a Zn monodentation or bidentation in metalloendopeptidases.
Biochemistry, 38, 1999
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1QF1
 | | THERMOLYSIN (E.C.3.4.24.27) COMPLEXED WITH (2-SULPHANYLHEPTANOYL)-PHE-ALA. PARAMETERS FOR ZN-BIDENTATION OF MERCAPTOACYLDIPEPTIDES IN METALLOENDOPEPTIDASE | | 分子名称: | CALCIUM ION, DIMETHYL SULFOXIDE, PROTEIN (THERMOLYSIN), ... | | 著者 | Gaucher, J.-F, Selkti, M, Tiraboschi, G, Prange, T, Roques, B.P, Tomas, A, Fournie-Zaluski, M.C. | | 登録日 | 1999-04-06 | | 公開日 | 1999-12-29 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal structures of alpha-mercaptoacyldipeptides in the thermolysin active site: structural parameters for a Zn monodentation or bidentation in metalloendopeptidases.
Biochemistry, 38, 1999
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1QF2
 | | THERMOLYSIN (E.C.3.4.24.27) COMPLEXED WITH (2-SULPHANYL-3-PHENYLPROPANOYL)-GLY-(5-PHENYLPROLINE). PARAMETERS FOR ZN-MONODENTATION OF MERCAPTOACYLDIPEPTIDES IN METALLOENDOPEPTIDASE | | 分子名称: | CALCIUM ION, DIMETHYL SULFOXIDE, PROTEIN (THERMOLYSIN), ... | | 著者 | Gaucher, J.-F, Selkti, M, Tiraboschi, G, Prange, T, Roques, B.P, Tomas, A, Fournie-Zaluski, M.C. | | 登録日 | 1999-04-06 | | 公開日 | 1999-12-29 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | | 主引用文献 | Crystal structures of alpha-mercaptoacyldipeptides in the thermolysin active site: structural parameters for a Zn monodentation or bidentation in metalloendopeptidases.
Biochemistry, 38, 1999
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1R1I
 | | STRUCTURAL ANALYSIS OF NEPRILYSIN WITH VARIOUS SPECIFIC AND POTENT INHIBITORS | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Neprilysin, ZINC ION, ... | | 著者 | Oefner, C, Roques, B.P, Fournie-Zaluski, M.C, Dale, G.E. | | 登録日 | 2003-09-24 | | 公開日 | 2004-09-28 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural analysis of neprilysin with various specific and potent inhibitors.
Acta Crystallogr.,Sect.D, 60, 2004
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1R1J
 | | STRUCTURAL ANALYSIS OF NEPRILYSIN WITH VARIOUS SPECIFIC AND POTENT INHIBITORS | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, N-(3-PHENYL-2-SULFANYLPROPANOYL)PHENYLALANYLALANINE, Neprilysin, ... | | 著者 | Oefner, C, Roques, B.P, Fournie-Zaluski, M.C, Dale, G.E. | | 登録日 | 2003-09-24 | | 公開日 | 2004-09-28 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Structural analysis of neprilysin with various specific and potent inhibitors.
Acta Crystallogr.,Sect.D, 60, 2004
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1R1H
 | | STRUCTURAL ANALYSIS OF NEPRILYSIN WITH VARIOUS SPECIFIC AND POTENT INHIBITORS | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, N-[3-[(1-AMINOETHYL)(HYDROXY)PHOSPHORYL]-2-(1,1'-BIPHENYL-4-YLMETHYL)PROPANOYL]ALANINE, Neprilysin, ... | | 著者 | Oefner, C, Roques, B.P, Fournie-Zaluski, M.C, Dale, G.E. | | 登録日 | 2003-09-24 | | 公開日 | 2004-09-28 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Structural analysis of neprilysin with various specific and potent inhibitors.
Acta Crystallogr.,Sect.D, 60, 2004
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2ZXG
 | | Aminopeptidase N complexed with the aminophosphinic inhibitor of PL250, a transition state analogue | | 分子名称: | Aminopeptidase N, GLYCEROL, N-{(2S)-3-[(1R)-1-aminoethyl](hydroxy)phosphoryl-2-benzylpropanoyl}-L-phenylalanine, ... | | 著者 | Nakajima, Y, Ito, K, Yoshimoto, T. | | 登録日 | 2008-12-24 | | 公開日 | 2009-08-25 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Structure of aminopeptidase N from Escherichia coli complexed with the transition-state analogue aminophosphinic inhibitor PL250
Acta Crystallogr.,Sect.D, 65, 2009
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1ESK
 | | SOLUTION STRUCTURE OF NCP7 FROM HIV-1 | | 分子名称: | GAG POLYPROTEIN, ZINC ION | | 著者 | Morellet, N, Demene, H, Teilleux, V, Huynh-Dinh, T, de Rocquigny, H, Fournie-Zaluski, M.-C, Roques, B.P. | | 登録日 | 2000-04-10 | | 公開日 | 2000-04-26 | | 最終更新日 | 2022-02-16 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution Structure of (12-53)NCp7 of HIV-1
To be Published
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3B7S
 | | [E296Q]LTA4H in complex with RSR substrate | | 分子名称: | ACETIC ACID, GLYCEROL, Leukotriene A-4 hydrolase, ... | | 著者 | Tholander, F, Haeggstrom, J, Thunnissen, M, Muroya, A, Roques, B.-P, Fournie-Zaluski, M.-C. | | 登録日 | 2007-10-31 | | 公開日 | 2008-09-16 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.465 Å) | | 主引用文献 | Structure-based dissection of the active site chemistry of leukotriene a4 hydrolase: implications for m1 aminopeptidases and inhibitor design.
Chem.Biol., 15, 2008
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3B7U
 | | Leukotriene A4 Hydrolase Complexed with KELatorphan | | 分子名称: | ACETIC ACID, IMIDAZOLE, Leukotriene A-4 hydrolase, ... | | 著者 | Tholander, F, Haeggstrom, J, Thunnissen, M, Muroya, A, Roques, B.-P, Fournie-Zaluski, M.-C. | | 登録日 | 2007-10-31 | | 公開日 | 2008-09-16 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structure-based dissection of the active site chemistry of leukotriene a4 hydrolase: implications for m1 aminopeptidases and inhibitor design.
Chem.Biol., 15, 2008
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3B7R
 | | Leukotriene A4 Hydrolase Complexed with Inhibitor RB3040 | | 分子名称: | IMIDAZOLE, Leukotriene A-4 hydrolase, N-[3-[(1-AMINOETHYL)(HYDROXY)PHOSPHORYL]-2-(1,1'-BIPHENYL-4-YLMETHYL)PROPANOYL]ALANINE, ... | | 著者 | Tholander, F, Haeggstrom, J, Thunnissen, M, Muroya, A, Roques, B.-P, Fournie-Zaluski, M.-C. | | 登録日 | 2007-10-31 | | 公開日 | 2008-09-16 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.811 Å) | | 主引用文献 | Structure-based dissection of the active site chemistry of leukotriene a4 hydrolase: implications for m1 aminopeptidases and inhibitor design.
Chem.Biol., 15, 2008
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3B7T
 | | [E296Q]LTA4H in complex with Arg-Ala-Arg substrate | | 分子名称: | IMIDAZOLE, Leukotriene A-4 hydrolase, RAR peptide, ... | | 著者 | Tholander, F, Haeggstrom, J, Thunnissen, M, Muroya, A, Roques, B.-P, Fournie-Zaluski, M.-C. | | 登録日 | 2007-10-31 | | 公開日 | 2008-09-16 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structure-based dissection of the active site chemistry of leukotriene a4 hydrolase: implications for m1 aminopeptidases and inhibitor design.
Chem.Biol., 15, 2008
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1OS0
 | | Thermolysin with an alpha-amino phosphinic inhibitor | | 分子名称: | CALCIUM ION, DIMETHYL SULFOXIDE, N-{(2R)-3-[(S)-[(1R)-1-amino-2-phenylethyl](hydroxy)phosphoryl]-2-benzylpropanoyl}-L-phenylalanine, ... | | 著者 | Selkti, M, Tomas, A, Prange, T. | | 登録日 | 2003-03-18 | | 公開日 | 2003-03-25 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Interactions of a new alpha-aminophosphinic derivative inside the active site of TLN (thermolysin): a model for zinc-metalloendopeptidase inhibition.
Acta Crystallogr.,Sect.D, 59, 2003
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1Q3Y
 | | NMR structure of the Cys28His mutant (D form) of the nucleocapsid protein NCp7 of HIV-1. | | 分子名称: | GAG protein, ZINC ION | | 著者 | Ramboarina, S, Druillennec, S, Morellet, N, Bouaziz, S, Roques, B.P. | | 登録日 | 2003-08-01 | | 公開日 | 2004-09-07 | | 最終更新日 | 2021-10-27 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Target specificity of human immunodeficiency virus type 1 NCp7 requires an intact conformation of its CCHC N-terminal zinc finger.
J.Virol., 78, 2004
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1Q3Z
 | | NMR structure of the Cys28His mutant (E form) of the nucleocapsid protein NCp7 of HIV-1. | | 分子名称: | GAG protein, ZINC ION | | 著者 | Ramboarina, S, Druillennec, S, Morellet, N, Bouaziz, S, Roques, B.P. | | 登録日 | 2003-08-01 | | 公開日 | 2004-09-07 | | 最終更新日 | 2021-10-27 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Target specificity of human immunodeficiency virus type 1 NCp7 requires an intact conformation of its CCHC N-terminal zinc finger.
J.Virol., 78, 2004
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