4V8Z
 
 | | Cryo-EM reconstruction of the 80S-eIF5B-Met-itRNAMet Eukaryotic Translation Initiation Complex | | 分子名称: | 18S RIBOSOMAL RNA, 25S RIBOSOMAL RNA, 40S RIBOSOMAL PROTEIN S0-A, ... | | 著者 | Fernandez, I.S, Bai, X.C, Hussain, T, Kelley, A.C, Lorsch, J.R, Ramakrishnan, V, Scheres, S.H.W. | | 登録日 | 2013-07-20 | | 公開日 | 2014-07-09 | | 最終更新日 | 2023-03-01 | | 実験手法 | ELECTRON MICROSCOPY (6.6 Å) | | 主引用文献 | Molecular architecture of a eukaryotic translational initiation complex.
Science, 342, 2013
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4V92
 | | Kluyveromyces lactis 80S ribosome in complex with CrPV-IRES | | 分子名称: | 18S RRNA, ES1, ES10, ... | | 著者 | Fernandez, I.S, Bai, X, Scheres, S.H.W, Ramakrishnan, V. | | 登録日 | 2014-03-21 | | 公開日 | 2014-07-09 | | 最終更新日 | 2019-12-11 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Initiation of Translation by Cricket Paralysis Virus Ires Requires its Translocation in the Ribosome.
Cell(Cambridge,Mass.), 157, 2014
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4V8Y
 | | Cryo-EM reconstruction of the 80S-eIF5B-Met-itRNAMet Eukaryotic Translation Initiation Complex | | 分子名称: | 18S RIBOSOMAL RNA, 25S RIBOSOMAL RNA, 40S RIBOSOMAL PROTEIN S0-A, ... | | 著者 | Fernandez, I.S, Bai, X.C, Hussain, T, Kelley, A.C, Lorsch, J.R, Ramakrishnan, V, Scheres, S.H.W. | | 登録日 | 2013-07-20 | | 公開日 | 2014-07-09 | | 最終更新日 | 2023-03-01 | | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | | 主引用文献 | Molecular architecture of a eukaryotic translational initiation complex.
Science, 342, 2013
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4V91
 | | Kluyveromyces lactis 80S ribosome in complex with CrPV-IRES | | 分子名称: | 25S RRNA, 5.8S RRNA, 5S RRNA, ... | | 著者 | Fernandez, I.S, Bai, X, Scheres, S.H.W, Ramakrishnan, V. | | 登録日 | 2014-03-21 | | 公開日 | 2014-07-09 | | 最終更新日 | 2019-12-11 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Initiation of Translation by Cricket Paralysis Virus Ires Requires its Translocation in the Ribosome.
Cell(Cambridge,Mass.), 157, 2014
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4V9I
 | | Crystal structure of thermus thermophilus 70S in complex with tRNAs and mRNA containing a pseudouridine in a stop codon | | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S Ribosomal protein S10, ... | | 著者 | Fernandez, I.S, Ng, C.L, Kelley, A.C, Guowei, W, Yu, Y.T, Ramakrishnan, V. | | 登録日 | 2013-04-04 | | 公開日 | 2014-07-09 | | 最終更新日 | 2014-12-10 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Unusual base pairing during the decoding of a stop codon by the ribosome.
Nature, 500, 2013
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4JYA
 | | Crystal structures of pseudouridinilated stop codons with ASLs | | 分子名称: | 16S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | | 著者 | Fernandez, I.S, Ng, C.L, Kelley, A.C, Guowei, W, Yu, Y.T, Ramakrishnan, V. | | 登録日 | 2013-03-29 | | 公開日 | 2013-06-26 | | 最終更新日 | 2013-08-21 | | 実験手法 | X-RAY DIFFRACTION (3.098 Å) | | 主引用文献 | Unusual base pairing during the decoding of a stop codon by the ribosome.
Nature, 500, 2013
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4JV5
 | | Crystal structures of pseudouridinilated stop codons with ASLs | | 分子名称: | 16S ribosomal RNA, 30S ribosomal protein 20, 30S ribosomal protein S10, ... | | 著者 | Fernandez, I.S, Ng, C.L, Kelley, A.C, Guowei, W, Yu, Y.T, Ramakrishnan, V. | | 登録日 | 2013-03-25 | | 公開日 | 2013-06-26 | | 最終更新日 | 2013-08-21 | | 実験手法 | X-RAY DIFFRACTION (3.162 Å) | | 主引用文献 | Unusual base pairing during the decoding of a stop codon by the ribosome.
Nature, 500, 2013
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4K0K
 | | Crystal structure of the Thermus thermophilus 30S ribosomal subunit complexed with a serine-ASL and mRNA containing a stop codon | | 分子名称: | 16S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | | 著者 | Fernandez, I.S, Ng, C.L, Kelley, A.C, Guowei, W, Yu, Y.T, Ramakrishnan, V. | | 登録日 | 2013-04-04 | | 公開日 | 2013-06-26 | | 最終更新日 | 2013-08-21 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Unusual base pairing during the decoding of a stop codon by the ribosome.
Nature, 500, 2013
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3BSQ
 | | Crystal structure of human kallikrein 7 produced as a secretion protein in E.coli | | 分子名称: | Kallikrein-7, SULFATE ION | | 著者 | Fernandez, I.S, Standker, L, Magert, H.J, Forssmann, W.G, Gimenez-Gallego, G, Romero, A. | | 登録日 | 2007-12-26 | | 公開日 | 2008-04-29 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Crystal structure of human epidermal kallikrein 7 (hK7) synthesized directly in its native state in E. coli: insights into the atomic basis of its inhibition by LEKTI domain 6 (LD6)
J.Mol.Biol., 377, 2008
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3FIM
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3JUT
 | | Acidic Fibroblast Growth Factor (FGF-1) complexed with gentisic acid | | 分子名称: | 2,5-dihydroxybenzoic acid, Heparin-binding growth factor 1 | | 著者 | Fernandez, I.S, Gimenez-Gallego, G, Romero, A. | | 登録日 | 2009-09-15 | | 公開日 | 2010-02-02 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Gentisic acid, a compound associated with plant defense and a metabolite of aspirin, heads a new class of in vivo fibroblast growth factor inhibitors.
J.Biol.Chem., 285, 2010
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2YMZ
 | | Crystal structure of chicken Galectin 2 | | 分子名称: | GALECTIN 2, SULFATE ION, beta-D-galactopyranose-(1-4)-beta-D-glucopyranose | | 著者 | Fernandez, I.S, Ruiz, F.M, Solis, D, Gabius, H.-J, Romero, A. | | 登録日 | 2012-10-11 | | 公開日 | 2013-08-28 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Fine-Tuning of Prototype Chicken Galectins: Structure of Cg-2 and Structure-Activity Correlations
Acta Crystallogr.,Sect.D, 69, 2013
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6UZ7
 | | K.lactis 80S ribosome with p/PE tRNA and eIF5B | | 分子名称: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0, ... | | 著者 | Fernandez, I.S, Huang, B.Y. | | 登録日 | 2019-11-14 | | 公開日 | 2020-01-15 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Long-range interdomain communications in eIF5B regulate GTP hydrolysis and translation initiation.
Proc.Natl.Acad.Sci.USA, 117, 2020
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7UFI
 | | VchTnsC AAA+ ATPase with DNA, single heptamer | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, DNA (5'-D(P*CP*TP*CP*CP*AP*GP*TP*AP*CP*AP*GP*CP*GP*CP*GP*GP*CP*TP*GP*AP*A)-3'), DNA (5'-D(P*TP*TP*CP*AP*GP*CP*CP*GP*CP*GP*CP*TP*GP*TP*AP*CP*TP*GP*GP*AP*G)-3'), ... | | 著者 | Fernandez, I.S, Sternberg, S.H. | | 登録日 | 2022-03-22 | | 公開日 | 2022-06-08 | | 最終更新日 | 2022-09-21 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Selective TnsC recruitment enhances the fidelity of RNA-guided transposition.
Nature, 609, 2022
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7UFM
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3K1X
 | | Acidic Fibroblast Growth Factor (FGF-1) complexed with dobesilate | | 分子名称: | 2,5-dihydroxybenzenesulfonic acid, Heparin-binding growth factor 1 | | 著者 | Romero, A, Fernandez, I.S, Gimenez-Gallego, G. | | 登録日 | 2009-09-29 | | 公開日 | 2010-02-02 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | | 主引用文献 | Gentisic acid, a compound associated with plant defense and a metabolite of aspirin, heads a new class of in vivo fibroblast growth factor inhibitors.
J.Biol.Chem., 285, 2010
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4V9H
 | | Crystal structure of the ribosome bound to elongation factor G in the guanosine triphosphatase state | | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Tourigny, D.S, Fernandez, I.S, Kelley, A.C, Ramakrishnan, V. | | 登録日 | 2013-03-25 | | 公開日 | 2014-07-09 | | 最終更新日 | 2014-12-10 | | 実験手法 | X-RAY DIFFRACTION (2.857 Å) | | 主引用文献 | Elongation factor G bound to the ribosome in an intermediate state of translocation.
Science, 340, 2013
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6W2S
 | | Structure of the Cricket Paralysis Virus 5-UTR IRES (CrPV 5-UTR-IRES) bound to the small ribosomal subunit in the open state (Class 1) | | 分子名称: | 18S rRNA, CrPV 5'-UTR IRES, Eukaryotic translation initiation factor 3 subunit A, ... | | 著者 | Neupane, R, Pisareva, V, Rodriguez, C.F, Pisarev, A, Fernandez, I.S. | | 登録日 | 2020-03-08 | | 公開日 | 2020-04-22 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.47 Å) | | 主引用文献 | A complex IRES at the 5'-UTR of a viral mRNA assembles a functional 48S complex via an uAUG intermediate.
Elife, 9, 2020
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6W2T
 | | Structure of the Cricket Paralysis Virus 5-UTR IRES (CrPV 5-UTR-IRES) bound to the small ribosomal subunit in the closed state (Class 2) | | 分子名称: | 18S rRNA, CrPV 5'-UTR IRES, Eukaryotic translation initiation factor 3 subunit A, ... | | 著者 | Neupane, R, Pisareva, V, Rodriguez, C.F, Pisarev, A, Fernandez, I.S. | | 登録日 | 2020-03-08 | | 公開日 | 2020-04-22 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.36 Å) | | 主引用文献 | A complex IRES at the 5'-UTR of a viral mRNA assembles a functional 48S complex via an uAUG intermediate.
Elife, 9, 2020
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6WOO
 | | CryoEM structure of yeast 80S ribosome with Met-tRNAiMet, eIF5B, and GDP | | 分子名称: | 18S ribosomal RNA, 25S ribosomal RNA, 5.8S ribosomal rRNA, ... | | 著者 | Wang, J, Wang, J, Puglisi, J, Fernandez, I.S. | | 登録日 | 2020-04-25 | | 公開日 | 2020-09-23 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | An active role of the eukaryotic large ribosomal subunit in translation initiation fidelity.
To Be Published
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6D9J
 | | Mammalian 80S ribosome with a double translocated CrPV-IRES, P-sitetRNA and eRF1. | | 分子名称: | 18S rRNA, 28S rRNA, 5.8S rRNA, ... | | 著者 | Pisareva, V.P, Pisarev, A.V, Fernandez, I.S. | | 登録日 | 2018-04-30 | | 公開日 | 2018-06-06 | | 最終更新日 | 2019-12-18 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Dual tRNA mimicry in the Cricket Paralysis Virus IRES uncovers an unexpected similarity with the Hepatitis C Virus IRES.
Elife, 7, 2018
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6D90
 | | Mammalian 80S ribosome with a double translocated CrPV-IRES, P-site tRNA and eRF1. | | 分子名称: | 18S rRNA, 28S rRNA, 5.8S rRNA, ... | | 著者 | Pisareva, V.P, Pisarev, A.V, Fernandez, I.S. | | 登録日 | 2018-04-27 | | 公開日 | 2018-06-06 | | 最終更新日 | 2019-12-18 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Dual tRNA mimicry in the Cricket Paralysis Virus IRES uncovers an unexpected similarity with the Hepatitis C Virus IRES.
Elife, 7, 2018
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7TQL
 | | CryoEM structure of the human 40S small ribosomal subunit in complex with translation initiation factors eIF1A and eIF5B. | | 分子名称: | 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | | 著者 | Lapointe, C.P, Grosely, R, Sokabe, M, Alvarado, C, Wang, J, Montabana, E, Villa, N, Shin, B, Dever, T, Fraser, C, Fernandez, I.S, Puglisi, J.D. | | 登録日 | 2022-01-26 | | 公開日 | 2022-04-27 | | 最終更新日 | 2022-12-14 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | eIF5B and eIF1A reorient initiator tRNA to allow ribosomal subunit joining.
Nature, 607, 2022
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5IQR
 | | Structure of RelA bound to the 70S ribosome | | 分子名称: | 30S ribosomal protein S10, 30S ribosomal protein S11, 30S ribosomal protein S12, ... | | 著者 | Brown, A, Fernandez, I.S, Gordiyenko, Y, Ramakrishnan, V. | | 登録日 | 2016-03-11 | | 公開日 | 2016-05-04 | | 最終更新日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Ribosome-dependent activation of stringent control.
Nature, 534, 2016
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5IT9
 | | Structure of the yeast Kluyveromyces lactis small ribosomal subunit in complex with the cricket paralysis virus IRES. | | 分子名称: | 18S ribosomal RNA, Cricket paralysis virus IRES RNA, MAGNESIUM ION, ... | | 著者 | Murray, J, Savva, C.G, Shin, B.S, Dever, T.E, Ramakrishnan, V, Fernandez, I.S. | | 登録日 | 2016-03-16 | | 公開日 | 2016-05-18 | | 最終更新日 | 2019-12-11 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structural characterization of ribosome recruitment and translocation by type IV IRES.
Elife, 5, 2016
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