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5W1H
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BU of 5w1h by Molmil
Crystal structure of LbaCas13a (C2c2) bound to mature crRNA (24-nt spacer)
Descriptor: GLYCEROL, IODIDE ION, LbaCas13a (C2c2), ...
Authors:Knott, G.J, Doudna, J.A.
Deposit date:2017-06-03
Release date:2017-09-13
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Guide-bound structures of an RNA-targeting A-cleaving CRISPR-Cas13a enzyme.
Nat. Struct. Mol. Biol., 24, 2017
5VVK
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BU of 5vvk by Molmil
Cas1-Cas2 bound to full-site mimic
Descriptor: CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2, DNA (5'-D(*GP*AP*CP*CP*AP*CP*CP*AP*GP*TP*G)-3'), ...
Authors:Wright, A.V, Knott, G.J, Doxzen, K.D, Doudna, J.A.
Deposit date:2017-05-19
Release date:2017-08-02
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structures of the CRISPR genome integration complex.
Science, 357, 2017
5VVJ
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BU of 5vvj by Molmil
Cas1-Cas2 bound to half-site intermediate
Descriptor: CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2, DNA (112-MER), ...
Authors:Wright, A.V, Knott, G.J, Doxzen, K.W, Doudna, J.A.
Deposit date:2017-05-19
Release date:2017-08-02
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.89 Å)
Cite:Structures of the CRISPR genome integration complex.
Science, 357, 2017
5W1I
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BU of 5w1i by Molmil
Crystal structure of LbaCas13a (C2c2) bound to mature crRNA (20-nt spacer)
Descriptor: IODIDE ION, LbaCas13a (C2c2), mature crRNA
Authors:Knott, G.J, Doudna, J.A.
Deposit date:2017-06-03
Release date:2017-09-13
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Guide-bound structures of an RNA-targeting A-cleaving CRISPR-Cas13a enzyme.
Nat. Struct. Mol. Biol., 24, 2017
5WFE
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BU of 5wfe by Molmil
Cas1-Cas2-IHF-DNA holo-complex
Descriptor: CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2, DNA (28-MER), ...
Authors:Wright, A.V, Liu, J.J, Nogales, E, Doudna, J.A.
Deposit date:2017-07-11
Release date:2017-08-02
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.64 Å)
Cite:Structures of the CRISPR genome integration complex.
Science, 357, 2017
5WLH
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BU of 5wlh by Molmil
Crystal structure of LbaCas13a H328A (C2c2) bound to pre-crRNA (24-nt spacer)
Descriptor: GLYCEROL, IODIDE ION, LbaCas13a H328A (C2c2), ...
Authors:Knott, G.J, Doudna, J.A.
Deposit date:2017-07-26
Release date:2017-09-13
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.80001032 Å)
Cite:Guide-bound structures of an RNA-targeting A-cleaving CRISPR-Cas13a enzyme.
Nat. Struct. Mol. Biol., 24, 2017
4AL6
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BU of 4al6 by Molmil
Crystal structure of the S148ACsy4-crRNA complex
Descriptor: CRRNA, 5'-R(CP*UP*GP*CP*CP*GP*UP*AP*UP*AP*GP*GP* CP*AP*GP*C)-3', CSY4 ENDORIBONUCLEASE
Authors:Haurwitz, R.E, Sternberg, S.H, Doudna, J.A.
Deposit date:2012-03-02
Release date:2012-06-13
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:Csy4 Relies on an Unusual Catalytic Dyad to Position and Cleave Crispr RNA.
Embo J., 31, 2012
4AN8
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BU of 4an8 by Molmil
Structure of Thermus thermophilus CasA (Cse1)
Descriptor: ACETATE ION, CSE1
Authors:Sashital, D.G, Wiedenheft, B, Doudna, J.A.
Deposit date:2012-03-16
Release date:2012-05-02
Last modified:2012-06-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Mechanism of Foreign DNA Selection in a Bacterial Adaptive Immune System.
Mol.Cell, 46, 2012
4AL7
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BU of 4al7 by Molmil
Crystal structure of the Csy4-minimal crRNA complex
Descriptor: 5'-R(*CP*UP*GP*CP*CP*GP*UP*AP*UP*AP*GP*GP*CP*AP*G)-3', CSY4 ENDORIBONUCLEASE
Authors:Haurwitz, R.E, Sternberg, S.H, Doudna, J.A.
Deposit date:2012-03-02
Release date:2012-06-13
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Csy4 Relies on an Unusual Catalytic Dyad to Position and Cleave Crispr RNA.
Embo J., 31, 2012
4AL5
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BU of 4al5 by Molmil
Crystal structure of the Csy4-crRNA product complex
Descriptor: 5'-R(*UP*UP*CP*AP*CP*UP*GP*CP*CP*GP*UP*AP*UP*AP *GP*GP*CP*AP*GP*C)-3', CSY4 ENDORIBONUCLEASE, GLYCEROL
Authors:Haurwitz, R.E, Sternberg, S.H, Doudna, J.A.
Deposit date:2012-03-02
Release date:2012-06-13
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Csy4 Relies on an Unusual Catalytic Dyad to Position and Cleave Crispr RNA.
Embo J., 31, 2012
4C8Y
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BU of 4c8y by Molmil
Cas6 (TTHA0078) substrate mimic complex
Descriptor: CAS6A, R1 REPEAT RNA SUBSTRATE MIMIC, SULFATE ION
Authors:Jinek, M, Niewoehner, O, Doudna, J.A.
Deposit date:2013-10-02
Release date:2013-11-06
Last modified:2014-02-12
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Evolution of Crispr RNA Recognition and Processing by Cas6 Endonucleases.
Nucleic Acids Res., 42, 2014
4C97
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BU of 4c97 by Molmil
Cas6 (TTHA0078) H37A mutant
Descriptor: CAS6A, SULFATE ION
Authors:Jinek, M, Niewoehner, O, Doudna, J.A.
Deposit date:2013-10-02
Release date:2013-11-06
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Evolution of Crispr RNA Recognition and Processing by Cas6 Endonucleases.
Nucleic Acids Res., 42, 2014
4C98
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BU of 4c98 by Molmil
Thermus thermophilus Cas6 (TTHB231)
Descriptor: CAS6B, ZINC ION
Authors:Jinek, M, Niewoehner, O, Doudna, J.A.
Deposit date:2013-10-02
Release date:2013-11-06
Last modified:2014-02-12
Method:X-RAY DIFFRACTION (2.001 Å)
Cite:Evolution of Crispr RNA Recognition and Processing by Cas6 Endonucleases.
Nucleic Acids Res., 42, 2014
4C8Z
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BU of 4c8z by Molmil
Cas6 (TTHA0078) product complex
Descriptor: CAS6A, POTASSIUM ION, R1 REPEAT RNA CLEAVAGE PRODUCT, ...
Authors:Jinek, M, Niewoehner, O, Doudna, J.A.
Deposit date:2013-10-02
Release date:2013-11-06
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.503 Å)
Cite:Evolution of Crispr RNA Recognition and Processing by Cas6 Endonucleases.
Nucleic Acids Res., 42, 2014
4C9D
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BU of 4c9d by Molmil
Cas6 (TTHB231) product complex
Descriptor: CAS6B, R3 REPEAT RNA CLEAVAGE PRODUCT
Authors:Jinek, M, Niewoehner, O, Doudna, J.A.
Deposit date:2013-10-02
Release date:2013-11-06
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3 Å)
Cite:Evolution of CRISPR RNA recognition and processing by Cas6 endonucleases.
Nucleic Acids Res., 42, 2014
4CMP
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BU of 4cmp by Molmil
Crystal structure of S. pyogenes Cas9
Descriptor: CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, MAGNESIUM ION, SULFATE ION
Authors:Jinek, M, Jiang, F, Taylor, D.W, Sternberg, S.H, Kaya, E, Ma, E, Anders, C, Hauer, M, Zhou, K, Lin, S, Kaplan, M, Iavarone, A.T, Charpentier, E, Nogales, E, Doudna, J.A.
Deposit date:2014-01-16
Release date:2014-02-12
Last modified:2014-03-26
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation.
Science, 343, 2014
4CMQ
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BU of 4cmq by Molmil
Crystal structure of Mn-bound S.pyogenes Cas9
Descriptor: CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, MANGANESE (II) ION, SULFATE ION
Authors:Jinek, M, Jiang, F, Taylor, D.W, Sternberg, S.H, Kaya, E, Ma, E, Anders, C, Hauer, M, Zhou, K, Lin, S, Kaplan, M, Iavarone, A.T, Charpentier, E, Nogales, E, Doudna, J.A.
Deposit date:2014-01-17
Release date:2014-02-12
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.09 Å)
Cite:Structures of Cas9 Endonucleases Reveal RNA- Mediated Conformational Activation
Science, 343, 2014
5CFN
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BU of 5cfn by Molmil
Crystal structure of anemone STING (Nematostella vectensis) in complex with 3',3' c-di-AMP, c[A(3',5')pA(3',5')p]
Descriptor: (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, Stimulator of Interferon Genes
Authors:Kranzusch, P.J, Wilson, S.C, Lee, A.S.Y, Berger, J.M, Doudna, J.A, Vance, R.E.
Deposit date:2015-07-08
Release date:2015-08-26
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling.
Mol.Cell, 59, 2015
5CFP
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BU of 5cfp by Molmil
Crystal structure of anemone STING (Nematostella vectensis) 'humanized' F276K in complex with 3', 3' c-di-GMP, c[G(3', 5')pG(3', 5')p]'
Descriptor: 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), Stimulator of Interferon Genes
Authors:Kranzusch, P.J, Wilson, S.C, Lee, A.S.Y, Berger, J.M, Doudna, J.A, Vance, R.E.
Deposit date:2015-07-08
Release date:2015-08-26
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.066 Å)
Cite:Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling.
Mol.Cell, 59, 2015
5CFL
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BU of 5cfl by Molmil
Crystal structure of anemone STING (Nematostella vectensis) in complex with 3', 3' c-di-GMP, c[G(3', 5')pG(3', 5')p]
Descriptor: 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), CITRATE ANION, Stimulator of Interferon Genes
Authors:Kranzusch, P.J, Wilson, S.C, Lee, A.S.Y, Berger, J.M, Doudna, J.A, Vance, R.E.
Deposit date:2015-07-08
Release date:2015-08-26
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.836 Å)
Cite:Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling.
Mol.Cell, 59, 2015
5CFO
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BU of 5cfo by Molmil
Crystal structure of anemone STING (Nematostella vectensis) in apo 'rotated' open conformation
Descriptor: Stimulator of Interferon Genes
Authors:Kranzusch, P.J, Wilson, S.C, Lee, A.S.Y, Berger, J.M, Doudna, J.A, Vance, R.E.
Deposit date:2015-07-08
Release date:2015-08-26
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.102 Å)
Cite:Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling.
Mol.Cell, 59, 2015
5CFR
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BU of 5cfr by Molmil
Crystal structure of anemone STING (Nematostella vectensis) in apo 'unrotated' closed conformation
Descriptor: CALCIUM ION, Stimulator of Interferon Genes
Authors:Kranzusch, P.J, Wilson, S.C, Lee, A.S.Y, Berger, J.M, Doudna, J.A, Vance, R.E.
Deposit date:2015-07-08
Release date:2015-08-26
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling.
Mol.Cell, 59, 2015
5CFQ
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BU of 5cfq by Molmil
Crystal structure of anemone STING (Nematostella vectensis) in complex with 2',3' cGAMP, c[G(2',5')pA(3',5')p]
Descriptor: SULFATE ION, Stimulator of Interferon Genes, cGAMP
Authors:Kranzusch, P.J, Wilson, S.C, Lee, A.S.Y, Berger, J.M, Doudna, J.A, Vance, R.E.
Deposit date:2015-07-08
Release date:2015-08-26
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.099 Å)
Cite:Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling.
Mol.Cell, 59, 2015
5CFM
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BU of 5cfm by Molmil
Crystal structure of anemone STING (Nematostella vectensis) in complex with 3', 3' cGAMP, c[G(3', 5')pA(3', 5')p]
Descriptor: 2-amino-9-[(2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one, CITRATE ANION, Stimulator of Interferon Genes
Authors:Kranzusch, P.J, Wilson, S.C, Lee, A.S.Y, Berger, J.M, Doudna, J.A, Vance, R.E.
Deposit date:2015-07-08
Release date:2015-08-26
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.994 Å)
Cite:Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling.
Mol.Cell, 59, 2015
5DS5
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BU of 5ds5 by Molmil
Crystal structure the Escherichia coli Cas1-Cas2 complex bound to protospacer DNA and Mg
Descriptor: CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2, DNA (28-MER), ...
Authors:Nunez, J.K, Harrington, L.B, Kranzusch, P.J, Engelman, A.N, Doudna, J.A.
Deposit date:2015-09-16
Release date:2015-10-28
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.951 Å)
Cite:Foreign DNA capture during CRISPR-Cas adaptive immunity.
Nature, 527, 2015

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