2FLR
 
 | | Novel 5-Azaindole Factor VIIa Inhibitors | | Descriptor: | Coagulation factor VII, Tissue factor, [2'-HYDROXY-3'-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-BIPHENYL-3-YLMETHYL]-UREA | | Authors: | Riggs, J.R, Hu, H, Kolesnikov, A, Tong, Z, Leahy, E.M, Wesson, K.E, Shrader, W.D, Vijaykumar, D, Wahl, T.A, Sprengeler, P.A, Green, M.J, Yu, C, Katz, B.A, Young, W.B. | | Deposit date: | 2006-01-06 | | Release date: | 2007-01-23 | | Last modified: | 2017-10-18 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Novel 5-azaindole factor VIIa inhibitors.
Bioorg.Med.Chem.Lett., 16, 2006
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2JRP
 | | Solution NMR Structure of YfgJ from Salmonella typhimurium Modeled with Two Zn+2 Bound, Northeast Structural Genomics Consortium Target StR86 | | Descriptor: | Putative cytoplasmic protein, ZINC ION | | Authors: | Ding, K, Ramelot, T.A, Cort, J.R, Wang, H, Nwosu, C, Cunningham, K, Owens, L, Ma, L, Xiao, R, Liu, J, Baran, M.C, Swapna, G.V.T, Acton, T.B, Rost, B, Montelione, G.T, Kennedy, M.A, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2007-06-28 | | Release date: | 2007-07-10 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution NMR Structure of YfgJ from Salmonella typhimurium Modeled with Two Zn+2 Bound.
To be Published
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2JRX
 | | Solution NMR structure of protein YejL from E. coli. Northeast Structural Genomics target ER309 | | Descriptor: | UPF0352 protein yejL | | Authors: | Cort, J.R, Zhao, L, Jiang, M, Cunningham, K, Ma, L.-C, Xiao, R, Liu, J, Baran, M.C, Swapna, G, Acton, T.B, Rost, B, Montelione, G.T, Kennedy, M.A, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2007-06-29 | | Release date: | 2007-08-07 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | NMR Chemical Shift Assignments of E. coli YejL protein.
To be Published
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2EZE
 | | SOLUTION STRUCTURE OF A COMPLEX OF THE SECOND DNA BINDING DOMAIN OF HUMAN HMG-I(Y) BOUND TO DNA DODECAMER CONTAINING THE PRDII SITE OF THE INTERFERON-BETA PROMOTER, NMR, 35 STRUCTURES | | Descriptor: | DNA (5'-D(*GP*AP*GP*GP*AP*AP*TP*TP*TP*CP*CP*C)-3'), DNA (5'-D(*GP*GP*GP*AP*AP*AP*TP*TP*CP*CP*TP*C)-3'), HIGH MOBILITY GROUP PROTEIN HMG-I/HMG-Y | | Authors: | Clore, G.M, Huth, J.R, Bewley, C, Gronenborn, A.M. | | Deposit date: | 1997-06-04 | | Release date: | 1997-10-15 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | The solution structure of an HMG-I(Y)-DNA complex defines a new architectural minor groove binding motif.
Nat.Struct.Biol., 4, 1997
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2FZP
 | | Crystal structure of the USP8 interaction domain of human NRDP1 | | Descriptor: | ring finger protein 41 isoform 1 | | Authors: | Walker, J.R, Avvakumov, G.V, Xue, S, Newman, E.M, Butler-Cole, C, Finerty Jr, P.J, Weigelt, J, Sundstrom, M, Arrowsmith, C, Edwards, A, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | | Deposit date: | 2006-02-10 | | Release date: | 2006-03-28 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.87 Å) | | Cite: | Amino-terminal Dimerization, NRDP1-Rhodanese Interaction, and Inhibited Catalytic Domain Conformation of the Ubiquitin-specific Protease 8 (USP8).
J.Biol.Chem., 281, 2006
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2G45
 | | Co-crystal structure of znf ubp domain from the deubiquitinating enzyme isopeptidase T (isot) in complex with ubiquitin | | Descriptor: | CHLORIDE ION, Ubiquitin, Ubiquitin carboxyl-terminal hydrolase 5, ... | | Authors: | Reyes-Turcu, F.E, Horton, J.R, Mullally, J.E, Heroux, A, Cheng, X, Wilkinson, K.D. | | Deposit date: | 2006-02-21 | | Release date: | 2006-04-04 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.99 Å) | | Cite: | The Ubiquitin Binding Domain ZnF UBP Recognizes the C-Terminal Diglycine Motif of Unanchored Ubiquitin.
Cell(Cambridge,Mass.), 124, 2006
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2G43
 | | Structure of the ZNF UBP domain from deubiquitinating enzyme isopeptidase T (IsoT) | | Descriptor: | UNKNOWN ATOM OR ION, Ubiquitin carboxyl-terminal hydrolase 5, ZINC ION | | Authors: | Reyes-Turcu, F.E, Horton, J.R, Mullally, J.E, Heroux, A, Cheng, X, Wilkinson, K.D. | | Deposit date: | 2006-02-21 | | Release date: | 2006-04-04 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.09 Å) | | Cite: | The Ubiquitin Binding Domain ZnF UBP Recognizes the C-Terminal Diglycine Motif of Unanchored Ubiquitin.
Cell(Cambridge,Mass.), 124, 2006
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2G6D
 | | Human cathepsin S mutant with vinyl sulfone inhibitor CRA-14009 | | Descriptor: | N-[(1S)-1-[({(1S)-3-PHENYL-1-[2-(PHENYLSULFONYL)ETHYL]PROPYL}AMINO)CARBONYL]-3-(PHENYLSULFONYL)PROPYL]MORPHOLINE-4-CARBOXAMIDE, cathepsin S | | Authors: | Somoza, J.R. | | Deposit date: | 2006-02-24 | | Release date: | 2006-04-04 | | Last modified: | 2021-10-20 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Human cathepsin S mutant with vinyl sulfone inhibitor CRA-14009
To be Published
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2H5X
 | | RuvA from Mycobacterium tuberculosis | | Descriptor: | GLYCEROL, Holliday junction ATP-dependent DNA helicase ruvA | | Authors: | Prabu, J.R, Thamotharan, S, Khanduja, J.S, Alipio, E.Z, Kim, C.Y, Waldo, G.S, Terwilliger, T.C, Segelke, B, Lekin, T, Toppani, D, Hung, L.W, Yu, M, Bursey, E, Muniyappa, K, Chandra, N.R, Vijayan, M. | | Deposit date: | 2006-05-28 | | Release date: | 2006-08-15 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structure of Mycobacterium tuberculosis RuvA, a protein involved in recombination.
ACTA CRYSTALLOGR.,SECT.F, 62, 2006
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2H3B
 | | Crystal Structure of Mouse Nicotinamide Phosphoribosyltransferase/Visfatin/Pre-B Cell Colony Enhancing Factor 1 | | Descriptor: | Nicotinamide phosphoribosyltransferase, SULFATE ION | | Authors: | Wang, T, Zhang, X, Bheda, P, Revollo, J.R, Imai, S.I, Wolberger, C. | | Deposit date: | 2006-05-22 | | Release date: | 2006-06-20 | | Last modified: | 2021-10-20 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Structure of Nampt/PBEF/visfatin, a mammalian NAD(+) biosynthetic enzyme.
Nat.Struct.Mol.Biol., 13, 2006
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2JOE
 | | NMR Structure of E. Coli YehR Protein. Northeast Structural Genomics Target ER538. | | Descriptor: | Hypothetical lipoprotein yehR | | Authors: | Ding, K, Ramelot, T.A, Cort, J.R, Chen, C.X, Jiang, M, Cunningham, K, Ma, L, Xiao, R, Liu, J, Baran, M.C, Swapna, G.V.T, Acton, T.B, Rost, B, Montelione, G.T, Kennedy, M.A, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2007-03-08 | | Release date: | 2007-04-10 | | Last modified: | 2024-05-08 | | Method: | SOLUTION NMR | | Cite: | NMR Structure of E. Coli YehR Protein
To be Published
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2GGM
 | | Human centrin 2 xeroderma pigmentosum group C protein complex | | Descriptor: | CALCIUM ION, Centrin-2, DNA-repair protein complementing XP-C cells | | Authors: | Thompson, J.R. | | Deposit date: | 2006-03-24 | | Release date: | 2006-04-25 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | The structure of the human centrin 2-xeroderma pigmentosum group C protein complex.
J.Biol.Chem., 281, 2006
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2K2E
 | | Solution NMR structure of Bordetella pertussis protein BP2786, a Mth938-like domain. Northeast Structural Genomics Consortium target BeR31 | | Descriptor: | Uncharacterized protein BP2786 | | Authors: | Cort, J.R, Ho, C.K, Nwosu, C, Maglaqui, M, Xiao, R, Liu, J, Baran, M.C, Swapna, G, Acton, T.B, Rost, B, Montelione, G.T, Kennedy, M.A, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2008-04-01 | | Release date: | 2008-04-22 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution NMR structure of Bordetella pertussis protein BP2786, a Mth938-like domain.
To be Published
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2K31
 | | Solution Structure of cGMP-binding GAF domain of Phosphodiesterase 5 | | Descriptor: | GUANOSINE-3',5'-MONOPHOSPHATE, Phosphodiesterase 5A, cGMP-specific | | Authors: | Heikaus, C.C, Stout, J.R, Sekharan, M.R, Eakin, C.M, Rajagopal, P, Brzovic, P.S, Beavo, J.A, Klevit, R.E. | | Deposit date: | 2008-04-16 | | Release date: | 2008-06-03 | | Last modified: | 2024-05-08 | | Method: | SOLUTION NMR | | Cite: | Solution Structure of the cGMP Binding GAF Domain from Phosphodiesterase 5: Insights into Nucleotide Selectivity, Dimerization, and cGMP-Dependent Conformational Change.
J.Biol.Chem., 283, 2008
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2FS9
 | | Human beta tryptase II with inhibitor CRA-28427 | | Descriptor: | ETHYL {(1S)-5-AMINO-1-[(5-{4-[(2,3-DIHYDRO-1H-INDEN-2-YLAMINO)CARBONYL]BENZYL}-1,2,4-OXADIAZOL-3-YL)CARBONYL]PENTYL}CARBAMATE, Tryptase beta-2 | | Authors: | Somoza, J.R. | | Deposit date: | 2006-01-21 | | Release date: | 2006-03-07 | | Last modified: | 2017-10-18 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structure-guided design of Peptide-based tryptase inhibitors.
Biochemistry, 45, 2006
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2JUZ
 | | Solution NMR structure of HI0947 from Haemophilus influenzae, Northeast Structural Genomics Consortium Target IR123 | | Descriptor: | UPF0352 protein HI0840 | | Authors: | Ding, K, Ramelot, T.A, Cort, J.R, Wang, D, Nwosu, C, Owens, L, Xiao, R, Liu, J, Baran, M.C, Swapna, G.V.T, Acton, T.B, Rost, B, Montelione, G.T, Kennedy, M.A, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2007-09-09 | | Release date: | 2007-10-02 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Solution NMR Structure of HI0947 from Haemophilus influenzae.
To be Published
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2JZ8
 | | Solution NMR structure of BH09830 from Bartonella henselae modeled with one Zn+2 bound. Northeast Structural Genomics Consortium target BnR55 | | Descriptor: | Uncharacterized protein BH09830, ZINC ION | | Authors: | Ding, K, Cort, J.R, Wang, D, Janjua, H, Owens, L, Xiao, R, Liu, J, Baran, M.C, Swapna, G.V.T, Acton, T.B, Rost, B, Montelione, G.T, Kennedy, M.A, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2007-12-30 | | Release date: | 2008-01-15 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution NMR structure of BH09830 from Bartonella henselae modeled with one Zn+2 bound.
To be Published
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2FYT
 | | Human HMT1 hnRNP methyltransferase-like 3 (S. cerevisiae) protein | | Descriptor: | Protein arginine N-methyltransferase 3, S-ADENOSYL-L-HOMOCYSTEINE | | Authors: | Min, J.R, Wu, H, Zeng, H, Loppnau, P, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | | Deposit date: | 2006-02-08 | | Release date: | 2006-03-14 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The Crystal Structure of Human HMT1 hnRNP
methyltransferase-like 3 in complex with SAH.
To be Published
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2G1P
 | | Structure of E. coli DNA adenine methyltransferase (DAM) | | Descriptor: | 5'-D(*TP*CP*TP*AP*GP*AP*TP*CP*TP*AP*GP*A)-3', DNA adenine methylase, GLYCEROL, ... | | Authors: | Horton, J.R, Liebert, K, Bekes, M, Jeltsch, A, Cheng, X. | | Deposit date: | 2006-02-14 | | Release date: | 2006-11-21 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.89 Å) | | Cite: | Structure and substrate recognition of the Escherichia coli DNA adenine methyltransferase.
J.Mol.Biol., 358, 2006
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2JN8
 | | Solution NMR structure of Q8ZRJ2 from Salmonella typhimurium. Northeast Structural Genomics target StR65. | | Descriptor: | Putative cytoplasmic protein | | Authors: | Aramini, J.M, Cort, J.R, Ho, C.K, Cunningham, K, Ma, L.-C, Xiao, R, Liu, J, Baran, M.C, Swapna, G.V.T, Acton, T.B, Rost, B, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2006-12-29 | | Release date: | 2007-01-30 | | Last modified: | 2023-12-20 | | Method: | SOLUTION NMR | | Cite: | Solution NMR structure of Q8ZRJ2 from Salmonella typhimurium. Northeast Structural Genomics target StR65.
To be Published
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2JNE
 | | NMR structure of E.coli YfgJ modelled with two Zn+2 bound. Northeast Structural Genomics Consortium Target ER317. | | Descriptor: | Hypothetical protein yfgJ, ZINC ION | | Authors: | Ramelot, T.A, Cort, J.R, Yee, A.A, Semesi, A, Lukin, J.A, Arrowsmith, C.H, Kennedy, M.A, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2007-01-12 | | Release date: | 2007-02-13 | | Last modified: | 2023-12-20 | | Method: | SOLUTION NMR | | Cite: | NMR structure of E.coli YfgJ bound to two Zn+2.
To be Published
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2G7R
 | | X-ray structure of the death domain of the human mucosa associated lymphoid tissue lymphoma translocation protein 1 | | Descriptor: | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | | Authors: | Walker, J.R, Wybenga-Groot, L, Newman, E.M, Finerty Jr, P.J, Butler-Cole, C, Weigelt, J, Sundstrom, M, Arrowsmith, C, Edwards, A, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | | Deposit date: | 2006-02-28 | | Release date: | 2006-04-04 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | X-ray structure of the death domain of the human mucosa associated lymphoid tissue lymphoma translocation protein 1
To be Published
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2JO6
 | | NMR structure of the E.coli protein NirD, Northeast Structural Genomics target ET100 | | Descriptor: | Nitrite reductase [NAD(P)H] small subunit | | Authors: | Ramelot, T.A, Cort, J.R, Yee, A.A, Guido, V, Lukin, J.A, Arrowsmith, C.H, Kennedy, M.A, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2007-02-21 | | Release date: | 2007-03-27 | | Last modified: | 2024-05-08 | | Method: | SOLUTION NMR | | Cite: | NMR structure of E.coli NirD.
To be Published
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2JR2
 | | Solution NMR structure of homodimer CPS_2611 from Colwellia psychrerythraea. Northeast Structural Genomics Consortium target CsR4. | | Descriptor: | UPF0352 protein CPS_2611 | | Authors: | Ramelot, T.A, Cort, J.R, Wang, H, Nwosu, C, Cunningham, K, Owens, L, Ma, L.-C, Xiao, R, Liu, J, Baran, M.C, Swapna, G, Acton, T.B, Rost, B, Montelione, G.T, Kennedy, M.A, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2007-06-19 | | Release date: | 2007-07-03 | | Last modified: | 2024-05-08 | | Method: | SOLUTION NMR | | Cite: | Solution NMR structure of homodimer CPS_2611 from Colwellia psychrerythraea.
To be Published
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2JKA
 | | Native structure of a family 97 alpha-glucosidase from Bacteroides thetaiotaomicron | | Descriptor: | 1,2-ETHANEDIOL, ALPHA-GLUCOSIDASE (ALPHA-GLUCOSIDASE SUSB), CALCIUM ION | | Authors: | Gloster, T.M, Turkenburg, J.P, Potts, J.R, Henrissat, B, Davies, G.J. | | Deposit date: | 2008-08-23 | | Release date: | 2008-09-30 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Divergence of Catalytic Mechanism within a Glycosidase Family Provides Insight Into Evolution of Carbohydrate Metabolism by Human Gut Flora.
Chem.Biol., 15, 2008
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