2K31
Solution Structure of cGMP-binding GAF domain of Phosphodiesterase 5
Summary for 2K31
Entry DOI | 10.2210/pdb2k31/pdb |
NMR Information | BMRB: 15734 |
Descriptor | Phosphodiesterase 5A, cGMP-specific, GUANOSINE-3',5'-MONOPHOSPHATE (2 entities in total) |
Functional Keywords | cyclic nucleotide phosphodiesterase, pde5, gaf domain, cgmp, hydrolase |
Biological source | Mus musculus (mouse) |
Total number of polymer chains | 1 |
Total formula weight | 20313.68 |
Authors | Heikaus, C.C.,Stout, J.R.,Sekharan, M.R.,Eakin, C.M.,Rajagopal, P.,Brzovic, P.S.,Beavo, J.A.,Klevit, R.E. (deposition date: 2008-04-16, release date: 2008-06-03, Last modification date: 2024-05-08) |
Primary citation | Heikaus, C.C.,Stout, J.R.,Sekharan, M.R.,Eakin, C.M.,Rajagopal, P.,Brzovic, P.S.,Beavo, J.A.,Klevit, R.E. Solution Structure of the cGMP Binding GAF Domain from Phosphodiesterase 5: Insights into Nucleotide Selectivity, Dimerization, and cGMP-Dependent Conformational Change. J.Biol.Chem., 283:22749-22759, 2008 Cited by PubMed: 18534985DOI: 10.1074/jbc.M801577200 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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