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7ORS
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BU of 7ors by Molmil
Ternary complex of 14-3-3 sigma, p27pT198 phosphopeptide, and WQ147
Descriptor: (4~{S})-~{N}-[(5-carbamimidoyl-3-phenyl-thiophen-2-yl)methyl]oxepane-4-carboxamide, 14-3-3 protein sigma, CHLORIDE ION, ...
Authors:Centorrino, F, Wu, Q, Ottmann, C.
Deposit date:2021-06-06
Release date:2022-06-22
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A crystallography-based study of fragment extensions into the 14-3-3 binding groove
To Be Published
7OQG
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BU of 7oqg by Molmil
Ternary complex of 14-3-3 sigma, Amot-p130 phosphopeptide, and WQ136
Descriptor: 14-3-3 protein sigma, Amot-p130 phosphopeptide (pS175), BETA-MERCAPTOETHANOL, ...
Authors:Centorrino, F, Ottmann, C.
Deposit date:2021-06-03
Release date:2022-06-22
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:A crystallography-based study of fragment extensions into the 14-3-3 binding groove
To Be Published
7OQJ
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BU of 7oqj by Molmil
Ternary complex of 14-3-3 sigma, Amot-p130 phosphopeptide, and WQ162
Descriptor: 14-3-3 protein sigma, Amot-p130 phosphopeptide (pS175), CHLORIDE ION, ...
Authors:Centorrino, F, Ottmann, C.
Deposit date:2021-06-03
Release date:2022-06-22
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:A crystallography-based study of fragment extensions into the 14-3-3 binding groove
To Be Published
7ORG
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BU of 7org by Molmil
Ternary complex of 14-3-3 sigma, p27pT198 phosphopeptide, and WQ162
Descriptor: 14-3-3 protein sigma, CHLORIDE ION, Cyclin-dependent kinase inhibitor 1B, ...
Authors:Centorrino, F, Wu, Q, Ottmann, C.
Deposit date:2021-06-05
Release date:2022-06-22
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A crystallography-based study of fragment extensions into the 14-3-3 binding groove
To Be Published
7OR3
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BU of 7or3 by Molmil
Ternary complex of 14-3-3 sigma, NotchpS1917 phosphopeptide, and WQ136
Descriptor: 14-3-3 protein sigma, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Centorrino, F, Wu, Q, Ottmann, C.
Deposit date:2021-06-04
Release date:2022-06-22
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A crystallography-based study of fragment extensions into the 14-3-3 binding groove
To Be Published
7ORH
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BU of 7orh by Molmil
Ternary complex of 14-3-3 sigma, p27pT198 phosphopeptide, and WQ178
Descriptor: 14-3-3 protein sigma, CHLORIDE ION, Cyclin-dependent kinase inhibitor 1B, ...
Authors:Centorrino, F, Wu, Q, Ottmann, C.
Deposit date:2021-06-05
Release date:2022-06-22
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A crystallography-based study of fragment extensions into the 14-3-3 binding groove
To Be Published
7OR8
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BU of 7or8 by Molmil
Ternary complex of 14-3-3 sigma, p27pT198 phosphopeptide, and WQ136
Descriptor: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ...
Authors:Centorrino, F, Wu, Q, Ottmann, C.
Deposit date:2021-06-04
Release date:2022-06-22
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A crystallography-based study of fragment extensions into the 14-3-3 binding groove
To Be Published
5MMW
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BU of 5mmw by Molmil
Crystal structure of the Retinoid X Receptor alpha in complex with synthetic honokiol derivative 6 and a fragment of the TIF2 co-activator.
Descriptor: (~{E})-3-[3-(2-methyl-3-phenyl-phenyl)-4-oxidanyl-phenyl]prop-2-enoic acid, LYS-ILE-LEU-HIS-ARG-LEU-LEU-GLN, Retinoic acid receptor RXR-alpha
Authors:Andrei, S.A, Brunsveld, L, Scheepstra, M, Ottmann, C.
Deposit date:2016-12-12
Release date:2017-11-08
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Ligand Dependent Switch from RXR Homo- to RXR-NURR1 Heterodimerization.
ACS Chem Neurosci, 8, 2017
5MHC
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BU of 5mhc by Molmil
Crystal structure of 14-3-3sigma and a p53 C-terminal 12-mer synthetic phosphopeptide
Descriptor: 14-3-3 protein sigma, CALCIUM ION, LYS-LEU-MET-PHE-LYS-TPO-GLU-GLY-PRO-ASP-SER-ASP, ...
Authors:Andrei, S, Ottmann, C, Leysen, S.
Deposit date:2016-11-24
Release date:2017-10-04
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Small-molecule stabilization of the p53 - 14-3-3 protein-protein interaction.
FEBS Lett., 591, 2017
5MKU
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BU of 5mku by Molmil
Crystal structure of the Retinoid X Receptor alpha in complex with synthetic honokiol derivative 4 and a fragment of the TIF2 co-activator.
Descriptor: (~{E})-3-[4-oxidanyl-3-(3-propan-2-ylphenyl)phenyl]prop-2-enoic acid, HIS-LYS-ILE-LEU-HIS-ARG-LEU-LEU-GLN-ASP-SER, Retinoic acid receptor RXR-alpha
Authors:Andrei, S.A, Brunsveld, L, Scheepstra, M, Ottmann, C.
Deposit date:2016-12-05
Release date:2017-11-08
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Ligand Dependent Switch from RXR Homo- to RXR-NURR1 Heterodimerization.
ACS Chem Neurosci, 8, 2017
5MYC
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BU of 5myc by Molmil
Crystal structure of human 14-3-3 sigma in complex with LRRK2 peptide pS910
Descriptor: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ...
Authors:Stevers, L.M, de Vries, R.M.J.M, Ottmann, C.
Deposit date:2017-01-26
Release date:2017-03-01
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.459 Å)
Cite:Structural interface between LRRK2 and 14-3-3 protein.
Biochem. J., 474, 2017
5MXO
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BU of 5mxo by Molmil
Crystal structure of 14-3-3sigma and a p53 C-terminal 12-mer synthetic phosphopeptide stabilized by Fusicoccin-A
Descriptor: 14-3-3 protein sigma, CHLORIDE ION, FUSICOCCIN, ...
Authors:Andrei, S, Ottmann, C, Leysen, S.
Deposit date:2017-01-24
Release date:2017-11-08
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Small-molecule stabilization of the p53 - 14-3-3 protein-protein interaction.
FEBS Lett., 591, 2017
5MOC
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BU of 5moc by Molmil
Crystal structure of 14-3-3sigma and a p53 C-terminal 12-mer synthetic phosphopeptide
Descriptor: 14-3-3 protein sigma, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Andrei, S, Ottmann, C, Leysen, S.
Deposit date:2016-12-14
Release date:2017-10-04
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Small-molecule stabilization of the p53 - 14-3-3 protein-protein interaction.
FEBS Lett., 591, 2017
5MK4
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BU of 5mk4 by Molmil
Crystal structure of the Retinoid X Receptor alpha in complex with synthetic honokiol derivative 7 and a fragment of the TIF2 co-activator.
Descriptor: (~{E})-3-[3-(2-methyl-5-phenyl-phenyl)-4-oxidanyl-phenyl]prop-2-enoic acid, CHLORIDE ION, Nuclear receptor coactivator 2, ...
Authors:Andrei, S.A, Scheepstra, M, Brunsveld, L, Ottmann, C.
Deposit date:2016-12-02
Release date:2017-11-08
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Ligand Dependent Switch from RXR Homo- to RXR-NURR1 Heterodimerization.
ACS Chem Neurosci, 8, 2017
5MY9
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BU of 5my9 by Molmil
Crystal structure of human 14-3-3 sigma in complex with LRRK2 peptide pS935
Descriptor: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ...
Authors:Stevers, L.M, de Vries, R.M.J.M, Ottmann, C.
Deposit date:2017-01-26
Release date:2017-03-01
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.327 Å)
Cite:Structural interface between LRRK2 and 14-3-3 protein.
Biochem. J., 474, 2017
5N5T
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BU of 5n5t by Molmil
14-3-3 sigma in complex with TAZ pS89 peptide and fragment NV2
Descriptor: 14-3-3 protein sigma, 4-[3,5-bis(chloranyl)pyridin-2-yl]oxyphenol, CHLORIDE ION, ...
Authors:Sijbesma, E, Leysen, S, Ottmann, C.
Deposit date:2017-02-14
Release date:2017-07-19
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Identification of Two Secondary Ligand Binding Sites in 14-3-3 Proteins Using Fragment Screening.
Biochemistry, 56, 2017
5N10
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BU of 5n10 by Molmil
Cucurbit[8]uril and 14-3-3 based binary bivalent supramolecular-protein assembly platform
Descriptor: 14-3-3 protein beta/alpha, Cucurbit[8]uril, Estrogen receptor, ...
Authors:de Vink, P.J, Ottmann, C.
Deposit date:2017-02-04
Release date:2017-05-24
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:A Binary Bivalent Supramolecular Assembly Platform Based on Cucurbit[8]uril and Dimeric Adapter Protein 14-3-3.
Angew. Chem. Int. Ed. Engl., 56, 2017
5N5W
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BU of 5n5w by Molmil
14-3-3 sigma in complex with TAZ pS89 peptide and fragment NV3
Descriptor: 14-3-3 protein sigma, 4-[3,5-bis(chloranyl)pyridin-2-yl]oxyaniline, CALCIUM ION, ...
Authors:Sijbesma, E, Leysen, S, Ottmann, C.
Deposit date:2017-02-14
Release date:2017-07-19
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.37 Å)
Cite:Identification of Two Secondary Ligand Binding Sites in 14-3-3 Proteins Using Fragment Screening.
Biochemistry, 56, 2017
5N75
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BU of 5n75 by Molmil
14-3-3 sigma in complex with TAZ pS89 peptide
Descriptor: 14-3-3 protein sigma, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Sijbesma, E, Leysen, S, Ottmann, C.
Deposit date:2017-02-19
Release date:2017-07-19
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.803 Å)
Cite:Identification of Two Secondary Ligand Binding Sites in 14-3-3 Proteins Using Fragment Screening.
Biochemistry, 56, 2017
5N5R
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BU of 5n5r by Molmil
14-3-3 sigma in complex with TAZ pS89 peptide and fragment NV1
Descriptor: 14-3-3 protein sigma, 2-azanyl-~{N}-(2,6-dimethylphenyl)-~{N}-propan-2-yl-ethanamide, CHLORIDE ION, ...
Authors:Sijbesma, E, Leysen, S, Ottmann, C.
Deposit date:2017-02-14
Release date:2017-07-19
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.801 Å)
Cite:Identification of Two Secondary Ligand Binding Sites in 14-3-3 Proteins Using Fragment Screening.
Biochemistry, 56, 2017
5MKJ
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BU of 5mkj by Molmil
Crystal structure of the Retinoid X Receptor alpha in complex with synthetic honokiol derivative 9 and a fragment of the TIF2 co-activator.
Descriptor: (~{E})-3-[4-oxidanyl-3-(5-prop-2-enyl-2-propoxy-phenyl)phenyl]prop-2-enoic acid, LYS-ILE-LEU-HIS-ARG-LEU-LEU-GLN-ASP, Retinoic acid receptor RXR-alpha
Authors:Andrei, S.A, Brunsveld, L, Scheepstra, M, Ottmann, C.
Deposit date:2016-12-05
Release date:2017-11-08
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Ligand Dependent Switch from RXR Homo- to RXR-NURR1 Heterodimerization.
ACS Chem Neurosci, 8, 2017
5MJ5
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BU of 5mj5 by Molmil
Crystal structure of the Retinoid X Receptor alpha in complex with synthetichonokiol derivative 3 and a fragment of the TIF2 co-activator.
Descriptor: (~{E})-3-[4-oxidanyl-3-[3-(phenylmethyl)phenyl]phenyl]prop-2-enoic acid, LYS-HIS-LYS-ILE-LEU-HIS-ARG-LEU-LEU-GLN-ASP-SER, Retinoic acid receptor RXR-alpha
Authors:Andrei, S.A, Brunsveld, L, Scheepstra, M, Ottmann, C.
Deposit date:2016-11-30
Release date:2017-11-08
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Ligand Dependent Switch from RXR Homo- to RXR-NURR1 Heterodimerization.
ACS Chem Neurosci, 8, 2017
6F08
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BU of 6f08 by Molmil
14-3-3 zeta in complex with the human Son of sevenless homolog 1 (SOS1)
Descriptor: 14-3-3 protein zeta/delta, PENTAETHYLENE GLYCOL, Son of sevenless homolog 1
Authors:Ballone, A, Centorrino, F, Ottmann, C, Guo, S, Leysen, S.
Deposit date:2017-11-17
Release date:2018-02-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural characterization of 14-3-3 zeta in complex with the human Son of sevenless homolog 1 (SOS1).
J. Struct. Biol., 202, 2018
6FAU
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BU of 6fau by Molmil
Crystal structure of C-terminal modified Tau peptide-hybrid 4.2e-I with 14-3-3sigma
Descriptor: (2~{R})-2-[(~{R})-(2-methoxyphenyl)-phenyl-methyl]pyrrolidine, 14-3-3 protein sigma, ACE-ARG-THR-PRO-SEP-LEU-PRO-GLY, ...
Authors:Andrei, S.A, Meijer, F.A, Ottmann, C, Milroy, L.G.
Deposit date:2017-12-18
Release date:2018-05-16
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes.
ACS Chem Neurosci, 9, 2018
6FI4
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BU of 6fi4 by Molmil
Crystal structure of C-terminal modified Tau peptide-hybrid 3.2e with 14-3-3sigma
Descriptor: (2~{S})-2-(diphenylmethyl)pyrrolidine, 14-3-3 protein sigma, CALCIUM ION, ...
Authors:Andrei, S.A, Meijer, F.A, Ottmann, C, Milroy, L.G.
Deposit date:2018-01-17
Release date:2018-05-16
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes.
ACS Chem Neurosci, 9, 2018

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