4JDE
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![BU of 4jde by Molmil](/molmil-images/mine/4jde) | Crystal structure of PUD-1/PUD-2 heterodimer | Descriptor: | CHLORIDE ION, GLYCEROL, Protein F15E11.1, ... | Authors: | Luo, S, Ye, K. | Deposit date: | 2013-02-25 | Release date: | 2013-11-06 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Characterization of PUD-1 and PUD-2, two proteins up-regulated in a long-lived daf-2 mutant. Plos One, 8, 2013
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5YZ9
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![BU of 5yz9 by Molmil](/molmil-images/mine/5yz9) | zinc finger domain of METTL3-METTL14 N6-methyladenosine methyltransferase | Descriptor: | N6-adenosine-methyltransferase catalytic subunit, ZINC ION | Authors: | Dong, X, Tang, C, Gong, Z, Yin, P, Huang, J.B. | Deposit date: | 2017-12-13 | Release date: | 2018-03-28 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR, SOLUTION SCATTERING | Cite: | Solution structure of the RNA recognition domain of METTL3-METTL14 N6-methyladenosine methyltransferase. Protein Cell, 10, 2019
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4RX5
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![BU of 4rx5 by Molmil](/molmil-images/mine/4rx5) | Bruton's tyrosine kinase (BTK) with pyridazinone compound 23 | Descriptor: | 2-(2-METHOXYETHOXY)ETHANOL, GLYCEROL, N-(6-fluoro-2-methyl-3-{5-[(5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-2-yl)amino]-6-oxo-1,6-dihydropyridazin-3-yl}phenyl)-1-benzothiophene-2-carboxamide, ... | Authors: | Eigenbrot, C, Yu, C. | Deposit date: | 2014-12-08 | Release date: | 2015-12-02 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.356 Å) | Cite: | Discovery of highly potent and selective Bruton's tyrosine kinase inhibitors: Pyridazinone analogs with improved metabolic stability. Bioorg.Med.Chem.Lett., 26, 2016
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7LHB
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![BU of 7lhb by Molmil](/molmil-images/mine/7lhb) | Crystal structure of Bcl-2 in complex with prodrug ABBV-167 | Descriptor: | Apoptosis regulator Bcl-2, Phosphoric acid mono-[5-(5-{4-[2-(4-chloro-phenyl)-4,4-dimethyl-cyclohex-1-enylmethyl]-piperazin-1-yl}-2-{3-nitro-4-[(tetrahydro-pyran-4-ylmethyl)-amino]-benzenesulfonylaminocarbonyl}-phenoxy)-pyrrolo[2,3-b]pyridin-7-ylmethyl] ester | Authors: | Judge, R.A, Salem, A.H. | Deposit date: | 2021-01-21 | Release date: | 2021-04-14 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.068 Å) | Cite: | Expanding the Repertoire for "Large Small Molecules": Prodrug ABBV-167 Efficiently Converts to Venetoclax with Reduced Food Effect in Healthy Volunteers. Mol.Cancer Ther., 20, 2021
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7LH7
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![BU of 7lh7 by Molmil](/molmil-images/mine/7lh7) | Crystal structure of BCL-XL in complex with a benzothiazole-based inhibitor | Descriptor: | Bcl-2-like protein 1, N-(1,3-benzothiazol-2-yl)-2-(4-{[(4-{[(2R)-4-(morpholin-4-yl)-1-(phenylsulfanyl)butan-2-yl]amino}-3-[(trifluoromethyl)sulfonyl]phenyl)sulfonyl]carbamoyl}-1,3-thiazol-2-yl)-1,2,3,4-tetrahydroisoquinoline-8-carboxamide | Authors: | Judge, R.A, Tao, Z. | Deposit date: | 2021-01-21 | Release date: | 2021-06-23 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.409 Å) | Cite: | Structure-Based Design of A-1293102, a Potent and Selective BCL-XL Inhibitor ACS Medicinal Chemistry Letters, 12, 2021
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4PRJ
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4PQN
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![BU of 4pqn by Molmil](/molmil-images/mine/4pqn) | ITK kinase domain with compound GNE-9822 | Descriptor: | 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, N-{1-[(1S)-3-(dimethylamino)-1-phenylpropyl]-1H-pyrazol-4-yl}-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazole-3-carboxamide, Tyrosine-protein kinase ITK/TSK | Authors: | McEwan, P.A, Barker, J.J, Eigenbrot, C. | Deposit date: | 2014-03-03 | Release date: | 2014-07-02 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.71 Å) | Cite: | Property- and structure-guided discovery of a tetrahydroindazole series of interleukin-2 inducible T-cell kinase inhibitors. J.Med.Chem., 57, 2014
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8C15
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![BU of 8c15 by Molmil](/molmil-images/mine/8c15) | Aurora A kinase in complex with TPX2-inhibitor 3 | Descriptor: | (1~{R},2~{R})-cyclohexane-1,2-dicarboxylic acid, 4-(4-chlorophenyl)-1~{H}-indole-6-carboxylic acid, ACETATE ION, ... | Authors: | Fischer, G, Rocaboy, M, Blaszczyk, B, Moschetti, T, Wang, X, Scott, D.E, Coyne, A.G, Dagostin, C, Rooney, T, Bayly, A, Feng, J, Asteian, A, Alcaide-Lopez, A, Stockwell, S, Skidmore, J, Venkitaraman, A.R, Abell, C, Blundell, T.L, Hyvonen, M. | Deposit date: | 2022-12-20 | Release date: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | Selective inhibitors of the Aurora A-TPX2 protein-protein interaction exhibit in vivo efficacy as targeted anti-mitotic agents To be published
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2MVJ
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7WN7
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![BU of 7wn7 by Molmil](/molmil-images/mine/7wn7) | Crystal structure of HearNPV P26 | Descriptor: | CHLORIDE ION, SULFATE ION, p26 | Authors: | Kuang, W, Hu, Z, Gong, P. | Deposit date: | 2022-01-17 | Release date: | 2022-11-23 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Dual roles and evolutionary implications of P26/poxin in antagonizing intracellular cGAS-STING and extracellular melanization immunity. Nat Commun, 13, 2022
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1HVW
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7EGH
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![BU of 7egh by Molmil](/molmil-images/mine/7egh) | TFIID lobe C subcomplex | Descriptor: | DNA (45-MER), Transcription initiation factor TFIID subunit 1, Transcription initiation factor TFIID subunit 2, ... | Authors: | Chen, X, Wu, Z, Li, J, Zhao, D, Xu, Y. | Deposit date: | 2021-03-24 | Release date: | 2021-05-12 | Method: | ELECTRON MICROSCOPY (3.04 Å) | Cite: | Structural insights into preinitiation complex assembly on core promoters. Science, 372, 2021
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7EGI
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![BU of 7egi by Molmil](/molmil-images/mine/7egi) | TFIID in rearranged conformation | Descriptor: | TATA-box-binding protein, Transcription initiation factor IIA subunit 1, Transcription initiation factor IIA subunit 2, ... | Authors: | Chen, X, Wu, Z, Li, J, Zhao, D, Xu, Y. | Deposit date: | 2021-03-24 | Release date: | 2021-05-12 | Method: | ELECTRON MICROSCOPY (9.82 Å) | Cite: | Structural insights into preinitiation complex assembly on core promoters. Science, 372, 2021
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7EGD
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![BU of 7egd by Molmil](/molmil-images/mine/7egd) | SCP promoter-bound TFIID-TFIIA in initial TBP-loading state | Descriptor: | DNA (72-MER), TATA-box-binding protein, Transcription initiation factor IIA subunit 1, ... | Authors: | Chen, X, Wu, Z, Li, J, Zhao, D, Xu, Y. | Deposit date: | 2021-03-24 | Release date: | 2021-05-12 | Method: | ELECTRON MICROSCOPY (6.75 Å) | Cite: | Structural insights into preinitiation complex assembly on core promoters. Science, 372, 2021
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7EGJ
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![BU of 7egj by Molmil](/molmil-images/mine/7egj) | SCP promoter-bound TFIID-TFIIA in post TBP-loading state | Descriptor: | DNA (74-MER), TATA-box-binding protein, Transcription initiation factor IIA subunit 1, ... | Authors: | Chen, X, Wu, Z, Li, J, Zhao, D, Xu, Y. | Deposit date: | 2021-03-24 | Release date: | 2021-05-12 | Method: | ELECTRON MICROSCOPY (8.64 Å) | Cite: | Structural insights into preinitiation complex assembly on core promoters. Science, 372, 2021
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7EGE
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![BU of 7ege by Molmil](/molmil-images/mine/7ege) | TFIID in canonical conformation | Descriptor: | TATA-box-binding protein, Transcription initiation factor TFIID subunit 1, Transcription initiation factor TFIID subunit 10, ... | Authors: | Chen, X, Wu, Z, Li, J, Zhao, D, Xu, Y. | Deposit date: | 2021-03-24 | Release date: | 2021-05-12 | Method: | ELECTRON MICROSCOPY (9 Å) | Cite: | Structural insights into preinitiation complex assembly on core promoters. Science, 372, 2021
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7EGG
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![BU of 7egg by Molmil](/molmil-images/mine/7egg) | TFIID lobe B subcomplex | Descriptor: | Transcription initiation factor TFIID subunit 10, Transcription initiation factor TFIID subunit 12, Transcription initiation factor TFIID subunit 4, ... | Authors: | Chen, X, Wu, Z, Li, J, Zhao, D, Xu, Y. | Deposit date: | 2021-03-24 | Release date: | 2021-05-05 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (2.77 Å) | Cite: | Structural insights into preinitiation complex assembly on core promoters. Science, 372, 2021
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7EGF
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![BU of 7egf by Molmil](/molmil-images/mine/7egf) | TFIID lobe A subcomplex | Descriptor: | TATA-box-binding protein, Transcription initiation factor TFIID subunit 10, Transcription initiation factor TFIID subunit 11, ... | Authors: | Chen, X, Wu, Z, Li, J, Zhao, D, Xu, Y. | Deposit date: | 2021-03-24 | Release date: | 2021-05-05 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.16 Å) | Cite: | Structural insights into preinitiation complex assembly on core promoters. Science, 2021
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7WHB
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![BU of 7whb by Molmil](/molmil-images/mine/7whb) | SARS-CoV-2 spike in complex with the ZB8 neutralizing antibody Fab (3U) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | Authors: | Zeng, J.W, Ge, J.W, Wang, X.Q. | Deposit date: | 2021-12-30 | Release date: | 2023-01-18 | Last modified: | 2023-09-06 | Method: | ELECTRON MICROSCOPY (2.67 Å) | Cite: | SARS-CoV-2 hijacks neutralizing dimeric IgA for nasal infection and injury in Syrian hamsters 1 . Emerg Microbes Infect, 12, 2023
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1C8A
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8IHM
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![BU of 8ihm by Molmil](/molmil-images/mine/8ihm) | Eaf3 CHD domain bound to the nucleosome | Descriptor: | Chromatin modification-related protein EAF3, DNA (164-MER), DNA (165-MER), ... | Authors: | Zhang, Y, Gang, C. | Deposit date: | 2023-02-23 | Release date: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.58 Å) | Cite: | Structural basis for nucleosome binding and catalysis by the yeast Rpd3S/HDAC holoenzyme. Cell Res., 33, 2023
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8IHN
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![BU of 8ihn by Molmil](/molmil-images/mine/8ihn) | Cryo-EM structure of the Rpd3S core complex | Descriptor: | CALCIUM ION, Chromatin modification-related protein EAF3, Histone H3, ... | Authors: | Zhang, Y, Gang, C. | Deposit date: | 2023-02-23 | Release date: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.37 Å) | Cite: | Structural basis for nucleosome binding and catalysis by the yeast Rpd3S/HDAC holoenzyme. Cell Res., 33, 2023
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8IHT
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![BU of 8iht by Molmil](/molmil-images/mine/8iht) | Rpd3S bound to the nucleosome | Descriptor: | CALCIUM ION, Chromatin modification-related protein EAF3, DNA (164-MER), ... | Authors: | Zhang, Y, Gang, C. | Deposit date: | 2023-02-23 | Release date: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.72 Å) | Cite: | Structural basis for nucleosome binding and catalysis by the yeast Rpd3S/HDAC holoenzyme. Cell Res., 33, 2023
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1C89
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![BU of 1c89 by Molmil](/molmil-images/mine/1c89) | |
2K9U
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![BU of 2k9u by Molmil](/molmil-images/mine/2k9u) | |