8C15

Aurora A kinase in complex with TPX2-inhibitor 3

Summary for 8C15

• Entry DOI: 10.2210/pdb8c15/pdb
• Descriptor: Aurora kinase A, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (9 entities in total)
• Functional Keywords: protein-ligand complex, kinase, protein-protein interaction inhibitor, tpx2, cell cycle
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 32461.70

Authors

Fischer, G.,Rocaboy, M.,Blaszczyk, B.,Moschetti, T.,Wang, X.,Scott, D.E.,Coyne, A.G.,Dagostin, C.,Rooney, T.,Bayly, A.,Feng, J.,Asteian, A.,Alcaide-Lopez, A.,Stockwell, S.,Skidmore, J.,Venkitaraman, A.R.,Abell, C.,Blundell, T.L.,Hyvonen, M. (deposition date: 2022-12-20, release date: 2024-01-10)

• Primary citation: Stockwell, S.,Scott, D.,Fischer, G.,Hyvonen, M.; Selective inhibitors of the Aurora A-TPX2 protein-protein interaction exhibit in vivo efficacy as targeted anti-mitotic agents; To be published,

Experimental method

X-RAY DIFFRACTION (2.41 Å)