4RX5
Bruton's tyrosine kinase (BTK) with pyridazinone compound 23
Summary for 4RX5
Entry DOI | 10.2210/pdb4rx5/pdb |
Descriptor | Tyrosine-protein kinase BTK, SULFATE ION, GLYCEROL, ... (6 entities in total) |
Functional Keywords | protein kinase, phosphotransfer catalyst, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q06187 |
Total number of polymer chains | 1 |
Total formula weight | 32814.64 |
Authors | Eigenbrot, C.,Yu, C. (deposition date: 2014-12-08, release date: 2015-12-02, Last modification date: 2023-09-20) |
Primary citation | Young, W.B.,Barbosa, J.,Blomgren, P.,Bremer, M.C.,Crawford, J.J.,Dambach, D.,Eigenbrot, C.,Gallion, S.,Johnson, A.R.,Kropf, J.E.,Lee, S.H.,Liu, L.,Lubach, J.W.,Macaluso, J.,Maciejewski, P.,Mitchell, S.A.,Ortwine, D.F.,Di Paolo, J.,Reif, K.,Scheerens, H.,Schmitt, A.,Wang, X.,Wong, H.,Xiong, J.M.,Xu, J.,Yu, C.,Zhao, Z.,Currie, K.S. Discovery of highly potent and selective Bruton's tyrosine kinase inhibitors: Pyridazinone analogs with improved metabolic stability. Bioorg.Med.Chem.Lett., 26:575-579, 2016 Cited by PubMed: 26675441DOI: 10.1016/j.bmcl.2015.11.076 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.356 Å) |
Structure validation
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