4H1Z
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![BU of 4h1z by Molmil](/molmil-images/mine/4h1z) | Crystal structure of putative isomerase from Sinorhizobium meliloti, open loop conformation (target EFI-502104) | Descriptor: | CHLORIDE ION, Enolase Q92Zs5, FORMIC ACID, ... | Authors: | Patskovsky, Y, Toro, R, Bhosle, R, Hillerich, B, Seidel, R.D, Washington, E, Scott Glenn, A, Chowdhury, S, Evans, B, Hammonds, J, Zencheck, W.D, Imker, H.J, Gerlt, J.A, Almo, S.C, Enzyme Function Initiative (EFI) | Deposit date: | 2012-09-11 | Release date: | 2012-09-26 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.012 Å) | Cite: | Crystal Structure of Enolase Q92Zs5 (Target EFI-502104) from Sinorhizobium meliloti To be Published
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4GXW
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![BU of 4gxw by Molmil](/molmil-images/mine/4gxw) | Crystal structure of a cog1816 amidohydrolase (target EFI-505188) from Burkhoderia ambifaria, with bound Zn | Descriptor: | Adenosine deaminase, CHLORIDE ION, ZINC ION | Authors: | Vetting, M.W, Goble, A.M, Morisco, L.L, Wasserman, S.R, Sojitra, S, Imker, H.J, Raushel, F.M, Gerlt, J.A, Almo, S.C, Enzyme Function Initiative (EFI) | Deposit date: | 2012-09-04 | Release date: | 2012-09-12 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Crystal structure of a cog1816 amidohydrolase (target EFI-505188) from Burkhoderia ambifaria, with bound Zn To be Published
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3LTP
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![BU of 3ltp by Molmil](/molmil-images/mine/3ltp) | Crystal structure of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP | Descriptor: | 6-HYDROXYURIDINE-5'-PHOSPHATE, Orotidine 5'-phosphate decarboxylase | Authors: | Fedorov, A.A, Fedorov, E.V, Wood, B.M, Gerlt, J.A, Almo, S.C. | Deposit date: | 2010-02-16 | Release date: | 2010-06-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Conformational changes in orotidine 5'-monophosphate decarboxylase: "remote" residues that stabilize the active conformation. Biochemistry, 49, 2010
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3LQ5
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![BU of 3lq5 by Molmil](/molmil-images/mine/3lq5) | Structure of CDK9/CyclinT in complex with S-CR8 | Descriptor: | (2S)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9H-purin-2-yl}amino)butan-1-ol, Cell division protein kinase 9, Cyclin-T1 | Authors: | Hole, A.J, Endicott, J.A, Baumli, S. | Deposit date: | 2010-02-08 | Release date: | 2011-01-19 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | CDK Inhibitors Roscovitine and CR8 Trigger Mcl-1 Down-Regulation and Apoptotic Cell Death in Neuroblastoma Cells Genes Cancer, 1, 2010
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3LTY
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![BU of 3lty by Molmil](/molmil-images/mine/3lty) | Crystal structure of the mutant V182A,I218A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP | Descriptor: | 6-HYDROXYURIDINE-5'-PHOSPHATE, Orotidine 5'-phosphate decarboxylase | Authors: | Fedorov, A.A, Fedorov, E.V, Wood, B.M, Gerlt, J.A, Almo, S.C. | Deposit date: | 2010-02-16 | Release date: | 2010-06-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Conformational changes in orotidine 5'-monophosphate decarboxylase: "remote" residues that stabilize the active conformation. Biochemistry, 49, 2010
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3LG5
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![BU of 3lg5 by Molmil](/molmil-images/mine/3lg5) | F198A Epi-isozizaene synthase: Complex with Mg, inorganic pyrophosphate and benzyl triethyl ammonium cation | Descriptor: | Epi-isozizaene synthase, MAGNESIUM ION, N-benzyl-N,N-diethylethanaminium, ... | Authors: | Aaron, J.A, Lin, X, Cane, D.E, Christianson, D.W. | Deposit date: | 2010-01-19 | Release date: | 2010-02-09 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.641 Å) | Cite: | Structure of Epi-Isozizaene Synthase from Streptomyces coelicolor A3(2), a Platform for New Terpenoid Cyclization Templates Biochemistry, 49, 2010
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3LRI
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![BU of 3lri by Molmil](/molmil-images/mine/3lri) | Solution structure and backbone dynamics of long-[Arg(3)]insulin-like growth factor-I | Descriptor: | PROTEIN (INSULIN-LIKE GROWTH FACTOR I) | Authors: | Laajoki, L.G, Francis, G.L, Wallace, J.C, Carver, J.A, Keniry, M.A. | Deposit date: | 1999-04-13 | Release date: | 2000-05-23 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | Solution structure and backbone dynamics of long-[Arg(3)]insulin-like growth factor-I J.Biol.Chem., 275, 2000
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3LV5
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![BU of 3lv5 by Molmil](/molmil-images/mine/3lv5) | Crystal structure of the mutant I199E of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP | Descriptor: | 6-HYDROXYURIDINE-5'-PHOSPHATE, Orotidine 5'-phosphate decarboxylase | Authors: | Fedorov, A.A, Fedorov, E.V, Wood, B.M, Gerlt, J.A, Almo, S.C. | Deposit date: | 2010-02-19 | Release date: | 2010-06-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.444 Å) | Cite: | Conformational changes in orotidine 5'-monophosphate decarboxylase: "remote" residues that stabilize the active conformation. Biochemistry, 49, 2010
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3LV6
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![BU of 3lv6 by Molmil](/molmil-images/mine/3lv6) | Crystal structure of the mutant I218F of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP | Descriptor: | 6-HYDROXYURIDINE-5'-PHOSPHATE, Orotidine 5'-phosphate decarboxylase | Authors: | Fedorov, A.A, Fedorov, E.V, Wood, B.M, Gerlt, J.A, Almo, S.C. | Deposit date: | 2010-02-19 | Release date: | 2010-06-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.451 Å) | Cite: | Conformational changes in orotidine 5'-monophosphate decarboxylase: "remote" residues that stabilize the active conformation. Biochemistry, 49, 2010
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3LVG
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![BU of 3lvg by Molmil](/molmil-images/mine/3lvg) | Crystal structure of a clathrin heavy chain and clathrin light chain complex | Descriptor: | Clathrin heavy chain 1, Clathrin light chain B | Authors: | Wilbur, J.D, Hwang, P.K, Ybe, J.A, Lane, M, Sellers, B.D, Jacobson, M.P, Fletterick, R.J, Brodsky, F.M. | Deposit date: | 2010-02-20 | Release date: | 2010-06-09 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (7.94 Å) | Cite: | Conformation switching of clathrin light chain regulates clathrin lattice assembly. Dev.Cell, 18, 2010
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3LX4
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![BU of 3lx4 by Molmil](/molmil-images/mine/3lx4) | Stepwise [FeFe]-hydrogenase H-cluster assembly revealed in the structure of HydA(deltaEFG) | Descriptor: | ACETATE ION, CHLORIDE ION, Fe-hydrogenase, ... | Authors: | Mulder, D.W, Boyd, E.S, Sarma, R, Lange, R.K, Endrizzi, J.A, Broderick, J.B, Peters, J.W. | Deposit date: | 2010-02-24 | Release date: | 2010-04-28 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Stepwise [FeFe]-hydrogenase H-cluster assembly revealed in the structure of HydA(DeltaEFG). Nature, 465, 2010
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3LZ9
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![BU of 3lz9 by Molmil](/molmil-images/mine/3lz9) | The Crystal Structure of 5-epi-aristolochene synthase M4 mutant complexed with (2-trans,6-trans)-2-fluorofarnesyl diphosphate | Descriptor: | (2Z,6E)-2-fluoro-3,7,11-trimethyldodeca-2,6,10-trien-1-yl trihydrogen diphosphate, Aristolochene synthase, MAGNESIUM ION | Authors: | Noel, J.P, Dellas, N, Faraldos, J.A, Zhao, M, Hess Jr, B.A, Smentek, L, Coates, R.M, O'Maille, P.E. | Deposit date: | 2010-03-01 | Release date: | 2010-04-07 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | Structural elucidation of cisoid and transoid cyclization pathways of a sesquiterpene synthase using 2-fluorofarnesyl diphosphates. Acs Chem.Biol., 5, 2010
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3LVH
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![BU of 3lvh by Molmil](/molmil-images/mine/3lvh) | Crystal structure of a clathrin heavy chain and clathrin light chain complex | Descriptor: | Clathrin heavy chain 1, Clathrin light chain B | Authors: | Wilbur, J.D, Hwang, P.K, Ybe, J.A, Lane, M, Sellers, B.D, Jacobson, M.P, Fletterick, R.J, Brodsky, F.M. | Deposit date: | 2010-02-20 | Release date: | 2010-06-09 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (9 Å) | Cite: | Conformation switching of clathrin light chain regulates clathrin lattice assembly. Dev.Cell, 18, 2010
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3M0P
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![BU of 3m0p by Molmil](/molmil-images/mine/3m0p) | |
3M0S
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![BU of 3m0s by Molmil](/molmil-images/mine/3m0s) | |
3MHB
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![BU of 3mhb by Molmil](/molmil-images/mine/3mhb) | Crystal structure of Staphylococcal nuclease variant Delta+PHS L38A at cryogenic temperature | Descriptor: | CALCIUM ION, THYMIDINE-3',5'-DIPHOSPHATE, Thermonuclease | Authors: | Caro, J.A, Schlessman, J.L, Garcia-Moreno, E.B, Heroux, A. | Deposit date: | 2010-04-07 | Release date: | 2011-03-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Cavities determine the pressure unfolding of proteins. Proc.Natl.Acad.Sci.USA, 109, 2012
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3M41
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![BU of 3m41 by Molmil](/molmil-images/mine/3m41) | Crystal structure of the mutant V182A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum | Descriptor: | GLYCEROL, Orotidine 5'-phosphate decarboxylase | Authors: | Fedorov, A.A, Fedorov, E.V, Wood, B.M, Gerlt, J.A, Almo, S.C. | Deposit date: | 2010-03-10 | Release date: | 2010-06-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Conformational changes in orotidine 5'-monophosphate decarboxylase: "remote" residues that stabilize the active conformation. Biochemistry, 49, 2010
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3M52
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![BU of 3m52 by Molmil](/molmil-images/mine/3m52) | Crystal structure of the BTB domain from the Miz-1/ZBTB17 transcription regulator | Descriptor: | ACETATE ION, ZINC ION, Zinc finger and BTB domain-containing protein 17 | Authors: | Stogios, P.J, Cuesta-Seijo, J.A, Chen, L, Prive, G.G. | Deposit date: | 2010-03-12 | Release date: | 2010-06-09 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.59 Å) | Cite: | Insights into Strand Exchange in BTB Domain Dimers from the Crystal Structures of FAZF and Miz1. J.Mol.Biol., 400, 2010
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3MEH
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![BU of 3meh by Molmil](/molmil-images/mine/3meh) | Crystal structure of Staphylococcal nuclease variant Delta+PHS I92A at cryogenic temperature | Descriptor: | CALCIUM ION, THYMIDINE-3',5'-DIPHOSPHATE, Thermonuclease | Authors: | Caro, J.A, Schlessman, J.L, Garcia-Moreno, E.B, Heroux, A. | Deposit date: | 2010-03-31 | Release date: | 2011-03-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Cavities determine the pressure unfolding of proteins. Proc.Natl.Acad.Sci.USA, 109, 2012
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3MP4
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![BU of 3mp4 by Molmil](/molmil-images/mine/3mp4) | Crystal structure of Human lyase R41M mutant | Descriptor: | Hydroxymethylglutaryl-CoA lyase | Authors: | Fu, Z, Runquist, J.A, Montgomery, C, Miziorko, H.M, Kim, J.-J.P. | Deposit date: | 2010-04-24 | Release date: | 2010-06-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Functional insights into human HMG-CoA lyase from structures of Acyl-CoA-containing ternary complexes. J.Biol.Chem., 285, 2010
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3MP3
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![BU of 3mp3 by Molmil](/molmil-images/mine/3mp3) | Crystal Structure of Human Lyase in complex with inhibitor HG-CoA | Descriptor: | (3R,5S,9R,21S)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9,21-tetrahydroxy-8,8-dimethyl-10,14,19-trioxo-2,4,6-trioxa-18-thia-11,15-diaza-3,5-diphosphatricosan-23-oic acid 3,5-dioxide, 3-HYDROXYPENTANEDIOIC ACID, Hydroxymethylglutaryl-CoA lyase, ... | Authors: | Fu, Z, Runquist, J.A, Montgomery, C, Miziorko, H.M, Kim, J.-J.P. | Deposit date: | 2010-04-24 | Release date: | 2010-06-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Functional insights into human HMG-CoA lyase from structures of Acyl-CoA-containing ternary complexes. J.Biol.Chem., 285, 2010
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5LQI
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![BU of 5lqi by Molmil](/molmil-images/mine/5lqi) | |
2FTC
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![BU of 2ftc by Molmil](/molmil-images/mine/2ftc) | Structural Model for the Large Subunit of the Mammalian Mitochondrial Ribosome | Descriptor: | 39S ribosomal protein L11, mitochondrial, 39S ribosomal protein L12, ... | Authors: | Mears, J.A, Sharma, M.R, Gutell, R.R, Richardson, P.E, Agrawal, R.K, Harvey, S.C. | Deposit date: | 2006-01-24 | Release date: | 2006-04-11 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (12.1 Å) | Cite: | A Structural Model for the Large Subunit of the Mammalian Mitochondrial Ribosome J.Mol.Biol., 358, 2006
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2FWQ
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2FQQ
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![BU of 2fqq by Molmil](/molmil-images/mine/2fqq) | Crystal structure of human caspase-1 (Cys285->Ala, Cys362->Ala, Cys364->Ala, Cys397->Ala) in complex with 1-methyl-3-trifluoromethyl-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (2-mercapto-ethyl)-amide | Descriptor: | 1-METHYL-3-TRIFLUOROMETHYL-1H-THIENO[2,3-C]PYRAZOLE-5-CARBOXYLIC ACID (2-MERCAPTO-ETHYL)-AMIDE, Caspase-1 | Authors: | Scheer, J.M, Wells, J.A, Romanowski, M.J. | Deposit date: | 2006-01-18 | Release date: | 2006-05-16 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | A common allosteric site and mechanism in caspases Proc.Natl.Acad.Sci.USA, 103, 2006
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