6T7H
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![BU of 6t7h by Molmil](/molmil-images/mine/6t7h) | Crystal structure of Thrombin in complex with macrocycle N14-PR4-A | Descriptor: | (14S,17R)-14-(3-carbamimidamidopropyl)-3-(furan-2-ylmethyl)-5,12,15-tris(oxidanylidene)-19-thia-3,6,13,16-tetrazatricyclo[19.4.0.0^{6,10}]pentacosa-1(25),7,9,21,23-pentaene-17-carboxamide, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Angelini, A, Kumar, M.G, Heinis, C, Cendron, L. | Deposit date: | 2019-10-22 | Release date: | 2020-09-30 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.32 Å) | Cite: | Macrocycle synthesis strategy based on step-wise "adding and reacting" three components enables screening of large combinatorial libraries. Chem Sci, 11, 2020
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5YU8
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![BU of 5yu8 by Molmil](/molmil-images/mine/5yu8) | Cofilin decorated actin filament | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | Authors: | Tanaka, K, Narita, A. | Deposit date: | 2017-11-21 | Release date: | 2018-05-23 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structural basis for cofilin binding and actin filament disassembly Nat Commun, 9, 2018
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5ZH3
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![BU of 5zh3 by Molmil](/molmil-images/mine/5zh3) | CRYSTAL STRUCTURE OF PfKRS WITH INHIBITOR CLADO-6 | Descriptor: | (3S)-6,8-dihydroxy-3-{[(2R,6R)-6-methyloxan-2-yl]methyl}-3,4-dihydro-1H-2-benzopyran-1-one, LYSINE, Lysine-tRNA ligase | Authors: | Babbar, P, Malhotra, N, Sharma, M, Harlos, K, Reddy, D.S, Manickam, Y, Sharma, A. | Deposit date: | 2018-03-11 | Release date: | 2018-06-27 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.86 Å) | Cite: | Specific Stereoisomeric Conformations Determine the Drug Potency of Cladosporin Scaffold against Malarial Parasite J. Med. Chem., 61, 2018
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5YVQ
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![BU of 5yvq by Molmil](/molmil-images/mine/5yvq) | Complex of Mu phage tail fiber and its chaperone | Descriptor: | GLYCEROL, Tail fiber assembly protein U, Tail fiber protein S | Authors: | Takeda, S, Sakai, K, Iwazaki, T, Yamashita, E, Nakagawa, A. | Deposit date: | 2017-11-27 | Release date: | 2019-05-22 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.103 Å) | Cite: | Phage tail fibre assembly proteins employ a modular structure to drive the correct folding of diverse fibres. Nat Microbiol, 4, 2019
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4EN9
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![BU of 4en9 by Molmil](/molmil-images/mine/4en9) | Crystal structure of HA70 (HA3) subcomponent of Clostridium botulinum type C progenitor toxin in complex with alpha 2-6-sialyllactosamine | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, Hemagglutinin components HA-22/23/53, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Yamashita, S, Yoshida, H, Tonozuka, T, Nishikawa, A, Kamitori, S. | Deposit date: | 2012-04-12 | Release date: | 2012-06-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.64 Å) | Cite: | Carbohydrate recognition mechanism of HA70 from Clostridium botulinum deduced from X-ray structures in complexes with sialylated oligosaccharides Febs Lett., 586, 2012
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1REE
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![BU of 1ree by Molmil](/molmil-images/mine/1ree) | ENDO-1,4-BETA-XYLANASE II COMPLEX WITH 3,4-EPOXYBUTYL-BETA-D-XYLOSIDE | Descriptor: | (3S)-3-hydroxybutyl beta-D-xylopyranoside, BENZOIC ACID, ENDO-1,4-BETA-XYLANASE II | Authors: | Rouvinen, J, Havukainen, R, Torronen, A. | Deposit date: | 1995-12-21 | Release date: | 1997-01-11 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Covalent binding of three epoxyalkyl xylosides to the active site of endo-1,4-xylanase II from Trichoderma reesei. Biochemistry, 35, 1996
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8P06
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![BU of 8p06 by Molmil](/molmil-images/mine/8p06) | Crystal structure of human Casein Kinase II subunit alpha (CK2a1) in complex with 5-((2-(4H-1,2,4-triazol-4-yl)pyridin-4-yl)amino)-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidine-3-carbonitrile | Descriptor: | 7-(cyclopropylamino)-5-[[2-(1,2,4-triazol-4-yl)pyridin-4-yl]amino]pyrazolo[1,5-a]pyrimidine-3-carbonitrile, CSNK2A1 protein, SULFATE ION | Authors: | Kraemer, A, Ong, H.W, Yang, X, Brown, J.W, Chang, E, Willson, T, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2023-05-09 | Release date: | 2023-06-21 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of human Casein Kinase II subunit alpha (CK2a1) in complex with 5-((2-(4H-1,2,4-triazol-4-yl)pyridin-4-yl)amino)-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidine-3-carbonitrile To Be Published
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8OWL
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![BU of 8owl by Molmil](/molmil-images/mine/8owl) | SR Ca(2+)-ATPase in the E2 state complexed with the photoswitch-thapsigargin derivative AzTG-6 | Descriptor: | ACETYL GROUP, SODIUM ION, Sarcoplasmic/endoplasmic reticulum calcium ATPase 1, ... | Authors: | Hjorth-Jensen, S.J, Konrad, D.B, Quistgaard, E.M.H, Hansen, L.C, Novak, A, Chu, H, Jurasek, M, Zimmermann, T, Andersen, J.L, Baran, P.S, Nissen, P, Trauner, D. | Deposit date: | 2023-04-28 | Release date: | 2023-06-21 | Method: | X-RAY DIFFRACTION (3.02 Å) | Cite: | Photoswitchable inhibitors of the sarco(endo)plasmic calcium pump To Be Published
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5Z1Z
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![BU of 5z1z by Molmil](/molmil-images/mine/5z1z) | The apo-structure of D-lactate dehydrogenase from Escherichia coli | Descriptor: | D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding, DI(HYDROXYETHYL)ETHER, MAGNESIUM ION | Authors: | Furukawa, N, Miyanaga, A, Nakajima, M, Taguchi, H. | Deposit date: | 2017-12-28 | Release date: | 2018-09-19 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Structural Basis of Sequential Allosteric Transitions in Tetrameric d-Lactate Dehydrogenases from Three Gram-Negative Bacteria. Biochemistry, 57, 2018
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6THW
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![BU of 6thw by Molmil](/molmil-images/mine/6thw) | IRAK4 in complex with inhibitor | Descriptor: | 7-fluoranyl-4-(1-methylcyclopropyl)oxy-~{N}-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-6-(2-methylpyrimidin-5-yl)pyrido[3,2-d]pyrimidin-2-amine, Interleukin-1 receptor-associated kinase 4 | Authors: | Xue, Y, Aagaard, A, Degorce, S.L. | Deposit date: | 2019-11-21 | Release date: | 2020-10-28 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.44 Å) | Cite: | Improving metabolic stability and removing aldehyde oxidase liability in a 5-azaquinazoline series of IRAK4 inhibitors. Bioorg.Med.Chem., 28, 2020
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8OR1
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![BU of 8or1 by Molmil](/molmil-images/mine/8or1) | Co-crystal strucutre of PD-L1 with low molecular weight inhibitor | Descriptor: | 5-[[5-[[2-chloranyl-3-(2-fluorophenyl)phenyl]methoxy]-2-[(~{E})-2-hydroxyethyliminomethyl]phenoxy]methyl]pyridine-3-carbonitrile, Programmed cell death 1 ligand 1 | Authors: | Zhang, H, Zhou, S, Wu, C, Zhu, M, Yu, Q, Wang, X, Awadasseid, A, Plewka, J, Magiera-Mularz, K, Wu, Y, Zhang, W. | Deposit date: | 2023-04-12 | Release date: | 2023-08-02 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Design, Synthesis, and Antitumor Activity Evaluation of 2-Arylmethoxy-4-(2,2'-dihalogen-substituted biphenyl-3-ylmethoxy) Benzylamine Derivatives as Potent PD-1/PD-L1 Inhibitors. J.Med.Chem., 66, 2023
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5ZQ2
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![BU of 5zq2 by Molmil](/molmil-images/mine/5zq2) | SidE apo form | Descriptor: | SidE | Authors: | Wang, Y, Gao, A, Gao, P. | Deposit date: | 2018-04-17 | Release date: | 2018-05-23 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.704 Å) | Cite: | Structural Insights into Non-canonical Ubiquitination Catalyzed by SidE. Cell, 173, 2018
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8P4F
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![BU of 8p4f by Molmil](/molmil-images/mine/8p4f) | Structural insights into human co-transcriptional capping - structure 6 | Descriptor: | 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1, DNA (38-MER), ... | Authors: | Garg, G, Dienemann, C, Farnung, L, Schwarz, J, Linden, A, Urlaub, H, Cramer, P. | Deposit date: | 2023-05-20 | Release date: | 2023-07-19 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structural insights into human co-transcriptional capping. Mol.Cell, 2023
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6TLR
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![BU of 6tlr by Molmil](/molmil-images/mine/6tlr) | HUMAN CK2 KINASE ALPHA SUBUNIT IN COMPLEX WITH THE ATP-COMPETITIVE INHIBITOR 4,7-DIBROMOBENZOTRIAZOLE | Descriptor: | 4,7-bis(bromanyl)-1~{H}-benzotriazole, CHLORIDE ION, Casein kinase II subunit alpha, ... | Authors: | Czapinska, H, Piasecka, A, Winiewska-Szajewska, M, Bochtler, M, Poznanski, J. | Deposit date: | 2019-12-03 | Release date: | 2020-12-16 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | Halogen Atoms in the Protein-Ligand System. Structural and Thermodynamic Studies of the Binding of Bromobenzotriazoles by the Catalytic Subunit of Human Protein Kinase CK2. J.Phys.Chem.B, 125, 2021
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4AI8
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![BU of 4ai8 by Molmil](/molmil-images/mine/4ai8) | FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH DAMINOZIDE | Descriptor: | DAMINOZIDE, GLYCEROL, HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR, ... | Authors: | King, O.N.F, Chowdhury, R, Rose, N.R, McDonough, M.A, Clifton, I.J, Schofield, C.J, Kawamura, A. | Deposit date: | 2012-02-08 | Release date: | 2012-10-03 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases. J. Med. Chem., 55, 2012
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8OW4
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![BU of 8ow4 by Molmil](/molmil-images/mine/8ow4) | 2.75 angstrom crystal structure of human NFAT1 with bound DNA | Descriptor: | DNA (5'-D(*AP*AP*CP*TP*AP*TP*TP*TP*TP*TP*CP*CP*AP*GP*C)-3'), DNA (5'-D(*TP*TP*GP*CP*TP*GP*GP*AP*AP*AP*AP*AP*TP*AP*G)-3'), Nuclear factor of activated T-cells, ... | Authors: | Lopez-Sagaseta, J, Erausquin, E, Hernandez-Morales, S, Urdiciain, A, Lasarte, J.J, Lozano, T. | Deposit date: | 2023-04-27 | Release date: | 2023-07-26 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | 2.75 angstrom crystal structure of human NFAT1 with bound DNA Not published
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2BK4
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![BU of 2bk4 by Molmil](/molmil-images/mine/2bk4) | Human Monoamine Oxidase B: I199F mutant in complex with rasagiline | Descriptor: | (1R)-N-(prop-2-en-1-yl)-2,3-dihydro-1H-inden-1-amine, AMINE OXIDASE [FLAVIN-CONTAINING] B, FLAVIN-ADENINE DINUCLEOTIDE | Authors: | Binda, C, Edmondson, D.E, Mattevi, A, Hubalek, F, Khalil, A, Li, M, Castagnoli, N. | Deposit date: | 2005-02-10 | Release date: | 2005-02-14 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Demonstration of Isoleucine 199 as a Structural Determinant for the Selective Inhibition of Human Monoamine Oxidase B by Specific Reversible Inhibitors J.Biol.Chem., 280, 2005
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5X8S
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![BU of 5x8s by Molmil](/molmil-images/mine/5x8s) | Crystal Structure of the mutant Human ROR gamma Ligand Binding Domain With Ursolic acid. | Descriptor: | Nuclear receptor ROR-gamma, Ursolic acid | Authors: | Noguchi, M, Nomura, A, Murase, K, Doi, S, Yamaguchi, K, Adachi, T. | Deposit date: | 2017-03-03 | Release date: | 2017-06-07 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Ternary complex of human ROR gamma ligand-binding domain, inverse agonist and SMRT peptide shows a unique mechanism of corepressor recruitment Genes Cells, 22, 2017
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6TA7
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![BU of 6ta7 by Molmil](/molmil-images/mine/6ta7) | CRYSTAL STRUCTURE OF HUMAN G3BP1-NTF2 IN COMPLEX WITH HUMAN CAPRIN1-DERIVED SOLOMON MOTIF | Descriptor: | CHLORIDE ION, Caprin-1, Ras GTPase-activating protein-binding protein 1, ... | Authors: | Schulte, T, Achour, A, Panas, M.D, McInerney, G.M. | Deposit date: | 2019-10-29 | Release date: | 2021-05-12 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Caprin-1 binding to the critical stress granule protein G3BP1 is regulated by pH Biorxiv, 2021
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4EYS
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![BU of 4eys by Molmil](/molmil-images/mine/4eys) | |
6TE3
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![BU of 6te3 by Molmil](/molmil-images/mine/6te3) | Crystal Structure of full-length Human Lysyl Hydroxylase LH3 - Cocrystal with Fe2+, Mn2+, UDP | Descriptor: | 2-OXOGLUTARIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Chiapparino, A, De Giorgi, F, Scietti, L, Faravelli, S, Roscioli, T, Forneris, F. | Deposit date: | 2019-11-11 | Release date: | 2021-05-19 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Identification of Regulatory Molecular 'Hot Spots' for LH/PLOD Collagen Glycosyltransferase Activity Int J Mol Sci, 2023
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8P4E
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![BU of 8p4e by Molmil](/molmil-images/mine/8p4e) | Structural insights into human co-transcriptional capping - structure 5 | Descriptor: | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1, DNA (26-MER), DNA (35-MER), ... | Authors: | Garg, G, Dienemann, C, Farnung, L, Schwarz, J, Linden, A, Urlaub, H, Cramer, P. | Deposit date: | 2023-05-20 | Release date: | 2023-07-19 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structural insights into human co-transcriptional capping. Mol.Cell, 2023
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6TEC
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![BU of 6tec by Molmil](/molmil-images/mine/6tec) | Crystal Structure of full-length Human Lysyl Hydroxylase LH3 - Cocrystal with Fe2+, Mn2+, UDP-Xylose | Descriptor: | 1,2-ETHANEDIOL, 2-OXOGLUTARIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Chiapparino, A, De Giorgi, F, Scietti, L, Faravelli, S, Roscioli, T, Forneris, F. | Deposit date: | 2019-11-11 | Release date: | 2021-05-19 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Identification of Regulatory Molecular 'Hot Spots' for LH/PLOD Collagen Glycosyltransferase Activity Int J Mol Sci, 2023
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6TES
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![BU of 6tes by Molmil](/molmil-images/mine/6tes) | Crystal Structure of full-length Human Lysyl Hydroxylase LH3 - Cocrystal with Fe2+, Mn2+, UDP-Glucuronic Acid | Descriptor: | 1,2-ETHANEDIOL, 2-OXOGLUTARIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Chiapparino, A, De Giorgi, F, Scietti, L, Faravelli, S, Roscioli, T, Forneris, F. | Deposit date: | 2019-11-12 | Release date: | 2021-05-19 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Identification of Regulatory Molecular 'Hot Spots' for LH/PLOD Collagen Glycosyltransferase Activity Int J Mol Sci, 2023
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4Y3Q
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![BU of 4y3q by Molmil](/molmil-images/mine/4y3q) | |