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6T7H

Crystal structure of Thrombin in complex with macrocycle N14-PR4-A

Summary for 6T7H
Entry DOI10.2210/pdb6t7h/pdb
DescriptorThrombin light chain, Thrombin heavy chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
Functional Keywordsserine protease, blood clotting factor, inhibition, macrocycle, hydrolase
Biological sourceHomo sapiens (Human)
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Total number of polymer chains4
Total formula weight69673.58
Authors
Angelini, A.,Kumar, M.G.,Heinis, C.,Cendron, L. (deposition date: 2019-10-22, release date: 2020-09-30, Last modification date: 2024-01-24)
Primary citationMothukuri, G.K.,Kale, S.S.,Stenbratt, C.L.,Zorzi, A.,Vesin, J.,Bortoli Chapalay, J.,Deyle, K.,Turcatti, G.,Cendron, L.,Angelini, A.,Heinis, C.
Macrocycle synthesis strategy based on step-wise "adding and reacting" three components enables screening of large combinatorial libraries.
Chem Sci, 11:7858-7863, 2020
Cited by
PubMed: 34094158
DOI: 10.1039/d0sc01944e
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.32 Å)
Structure validation

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