6QK9
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7KXJ
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![BU of 7kxj by Molmil](/molmil-images/mine/7kxj) | SARS-CoV-2 spike protein in complex with Fab 15033-7, 3-"up", asymmetric | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab 15033-7 heavy chain, ... | Authors: | Li, Z, Rini, J. | Deposit date: | 2020-12-04 | Release date: | 2021-02-03 | Last modified: | 2021-08-25 | Method: | ELECTRON MICROSCOPY (6.4 Å) | Cite: | Tetravalent SARS-CoV-2 Neutralizing Antibodies Show Enhanced Potency and Resistance to Escape Mutations. J.Mol.Biol., 433, 2021
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7KXK
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![BU of 7kxk by Molmil](/molmil-images/mine/7kxk) | SARS-CoV-2 spike protein in complex with Fab 15033-7, 2-"up"-1-"down" conformation | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab 15033-7 heavy chain, ... | Authors: | Li, Z, Rini, J. | Deposit date: | 2020-12-04 | Release date: | 2021-02-03 | Last modified: | 2021-08-25 | Method: | ELECTRON MICROSCOPY (5 Å) | Cite: | Tetravalent SARS-CoV-2 Neutralizing Antibodies Show Enhanced Potency and Resistance to Escape Mutations. J.Mol.Biol., 433, 2021
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3I3T
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![BU of 3i3t by Molmil](/molmil-images/mine/3i3t) | Crystal structure of covalent ubiquitin-USP21 complex | Descriptor: | ETHANAMINE, Ubiquitin, Ubiquitin carboxyl-terminal hydrolase 21, ... | Authors: | Neculai, D, Avvakumov, G.V, Walker, J.R, Xue, S, Butler-Cole, C, Weigelt, J, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | Deposit date: | 2009-06-30 | Release date: | 2009-07-21 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.59 Å) | Cite: | A strategy for modulation of enzymes in the ubiquitin system. Science, 339, 2013
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3P9W
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3N85
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4K94
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![BU of 4k94 by Molmil](/molmil-images/mine/4k94) | Crystal structure of KIT D4D5 fragment in complex with anti-Kit antibody Fab19 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab19 heavy chain, Fab19 light chain, ... | Authors: | Resheynyak, A.V, Boggon, T.J, Lax, I, Schlessinger, J. | Deposit date: | 2013-04-19 | Release date: | 2013-10-16 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural basis for KIT receptor tyrosine kinase inhibition by antibodies targeting the D4 membrane-proximal region. Proc.Natl.Acad.Sci.USA, 110, 2013
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4JXT
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![BU of 4jxt by Molmil](/molmil-images/mine/4jxt) | CID of human RPRD1A in complex with a phosphorylated peptide from RPB1-CTD | Descriptor: | DNA-directed RNA polymerase II subunit RPB1, Regulation of nuclear pre-mRNA domain-containing protein 1A, UNKNOWN ATOM OR ION | Authors: | Ni, Z, Xu, C, Tempel, W, El Bakkouri, M, Loppnau, P, Guo, X, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Min, J, Greenblatt, J.F, Structural Genomics Consortium (SGC) | Deposit date: | 2013-03-28 | Release date: | 2013-11-13 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation. Nat.Struct.Mol.Biol., 21, 2014
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4K9E
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![BU of 4k9e by Molmil](/molmil-images/mine/4k9e) | Crystal structure of KIT D4D5 fragment in complex with anti-Kit antibodies Fab79D | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Mast/stem cell growth factor receptor Kit, heavy chain, ... | Authors: | Resheynyak, A.V, Boggon, T.J, Lax, I, Schlessinger, J. | Deposit date: | 2013-04-19 | Release date: | 2013-10-16 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural basis for KIT receptor tyrosine kinase inhibition by antibodies targeting the D4 membrane-proximal region. Proc.Natl.Acad.Sci.USA, 110, 2013
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6NXL
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![BU of 6nxl by Molmil](/molmil-images/mine/6nxl) | Ubiquitin binding variants | Descriptor: | Polyubiquitin-B | Authors: | Miller, D.J, Watson, E.R. | Deposit date: | 2019-02-08 | Release date: | 2020-01-15 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.803 Å) | Cite: | Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site. Proc.Natl.Acad.Sci.USA, 116, 2019
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6NJG
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6O3B
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![BU of 6o3b by Molmil](/molmil-images/mine/6o3b) | Crystal structure of Frizzled 7 CRD in complex with F6 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody Fab F6, Heavy chain, ... | Authors: | Raman, S, Beilschmidt, M, Fransson, J, Julien, J.P. | Deposit date: | 2019-02-26 | Release date: | 2019-04-03 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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6O39
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![BU of 6o39 by Molmil](/molmil-images/mine/6o39) | Crystal structure of Frizzled 5 CRD in complex with F2.I Fab | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ... | Authors: | Raman, S, Beilschmidt, M, Fransson, J, Julien, J.P. | Deposit date: | 2019-02-26 | Release date: | 2019-04-03 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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6NXK
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![BU of 6nxk by Molmil](/molmil-images/mine/6nxk) | Ubiquitin binding variants | Descriptor: | Anaphase-promoting complex subunit 2, Polyubiquitin-C | Authors: | Miller, D.J, Watson, E.R. | Deposit date: | 2019-02-08 | Release date: | 2020-01-15 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site. Proc.Natl.Acad.Sci.USA, 116, 2019
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6OB1
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![BU of 6ob1 by Molmil](/molmil-images/mine/6ob1) | Structure of WHB in complex with Ubiquitin Variant | Descriptor: | Anaphase-promoting complex subunit 2, Ubiquitin | Authors: | Edmond, R.W, Grace, C.R. | Deposit date: | 2019-03-19 | Release date: | 2019-08-14 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site. Proc.Natl.Acad.Sci.USA, 116, 2019
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6O3A
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![BU of 6o3a by Molmil](/molmil-images/mine/6o3a) | Crystal structure of Frizzled 7 CRD in complex with F7.B Fab | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, ... | Authors: | Raman, S, Beilschmidt, M, Fransson, J, Julien, J.P. | Deposit date: | 2019-02-26 | Release date: | 2019-04-03 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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7M3Q
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![BU of 7m3q by Molmil](/molmil-images/mine/7m3q) | Structure of the Smurf2 HECT Domain with a High Affinity Ubiquitin Variant (UbV) | Descriptor: | 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, CHLORIDE ION, ... | Authors: | Chowdhury, A, Singer, A.U, Ogunjimi, A.A, Teyra, J, Zhang, W, Sicheri, F, Sidhu, S.S. | Deposit date: | 2021-03-18 | Release date: | 2021-04-21 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of the Smurf2 HECT Domain with a High Affinity Ubiquitin Variant (UbV) To be published
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2H9G
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8T6I
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![BU of 8t6i by Molmil](/molmil-images/mine/8t6i) | Structure of VHH-Fab complex with engineered Crystal Kappa region | Descriptor: | Fab heavy chain, Fab light chain, GLYCEROL, ... | Authors: | Filippova, E.V, Thompson, I, Kossiakoff, A.A. | Deposit date: | 2023-06-16 | Release date: | 2023-11-29 | Last modified: | 2024-01-03 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Engineered antigen-binding fragments for enhanced crystallization of antibody:antigen complexes. Protein Sci., 33, 2024
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8T9Y
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![BU of 8t9y by Molmil](/molmil-images/mine/8t9y) | Structure of VHH-Fab complex with engineered Elbow FNQIKG and Crystal Kappa regions | Descriptor: | DI(HYDROXYETHYL)ETHER, Fab heavy chain, Fab light chain, ... | Authors: | Filippova, E.V, Thompson, I, Kossiakoff, A.A. | Deposit date: | 2023-06-26 | Release date: | 2023-11-29 | Last modified: | 2024-01-03 | Method: | X-RAY DIFFRACTION (2.52 Å) | Cite: | Engineered antigen-binding fragments for enhanced crystallization of antibody:antigen complexes. Protein Sci., 33, 2024
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8T58
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8T8I
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![BU of 8t8i by Molmil](/molmil-images/mine/8t8i) | Structure of VHH-Fab complex with engineered Elbow FNQIKG, Crystal Kappa and SER substitutions | Descriptor: | CHLORIDE ION, DI(HYDROXYETHYL)ETHER, Fab heavy chain, ... | Authors: | Filippova, E.V, Thompson, I, Kossiakoff, A.A. | Deposit date: | 2023-06-22 | Release date: | 2023-11-29 | Last modified: | 2024-01-03 | Method: | X-RAY DIFFRACTION (2.52 Å) | Cite: | Engineered antigen-binding fragments for enhanced crystallization of antibody:antigen complexes. Protein Sci., 33, 2024
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5HPK
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![BU of 5hpk by Molmil](/molmil-images/mine/5hpk) | System-wide modulation of HECT E3 ligases with selective ubiquitin variant probes: NEDD4L and UbV NL.1 | Descriptor: | E3 ubiquitin-protein ligase NEDD4-like, Ubiquitin variant NL.1 | Authors: | Wu, K.-P, Mukherjee, M, Mercredi, P.Y, Schulman, B.A. | Deposit date: | 2016-01-20 | Release date: | 2016-03-16 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.431 Å) | Cite: | System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes. Mol.Cell, 62, 2016
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5HPT
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5HPL
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![BU of 5hpl by Molmil](/molmil-images/mine/5hpl) | |